Information on EC 1.1.1.213 - 3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)

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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota

EC NUMBER
COMMENTARY
1.1.1.213
-
RECOMMENDED NAME
GeneOntology No.
3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
PATHWAY
KEGG Link
MetaCyc Link
bile acid biosynthesis, neutral pathway
-
Steroid hormone biosynthesis
-
testosterone and androsterone degradation to androstendione
-
SYSTEMATIC NAME
IUBMB Comments
3alpha-hydroxysteroid:NAD(P)+ 3-oxidoreductase (Re-specific)
The enzyme acts on multiple 3alpha-hydroxysteroids. Re-specific with respect to NAD+ or NADP+ [cf. EC 1.1.1.50, 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)]. Enzymes whose stereo-specificity with respect to NAD+ or NADP+ is not known are described by EC 1.1.1.357, 3alpha-hydroxysteroid 3-dehydrogenase.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
17beta-hydroxysteroid dehydrogenase type 5
-
-
3-alpha hydroxysteroid oxidoreductase
-
-
3-alpha-HSO
-
-
3alpha-HSD
P52895
-
3alpha-HSD type 3
P52895
-
3alpha-HSD3
-
-
3alpha-HSOR
-
-
3alpha-hydroxysteroid dehydrogenase
-
-
-
-
3alpha-hydroxysteroid dehydrogenase
-
-
3alpha-hydroxysteroid dehydrogenase
P52895
-
3alpha-hydroxysteroid dehydrogenase
-
-
3alpha-hydroxysteroid dehydrogenase
-
-
3alpha-hydroxysteroid dehydrogenase
-
-
-
3alpha-hydroxysteroid dehydrogenase
-
-
3alpha-hydroxysteroid dehydrogenase (B-specific)
-
-
-
-
3alpha-hydroxysteroid dehydrogenase type 2
-
-
3alpha-hydroxysteroid dehydrogenase/carbonyl reductase
-
-
3alpha-hydroxysteroid oxido-reductase
-
-
3alpha-hydroxysteroid oxidoreductase
-
-
-
-
3alpha-hydroxysteroid:NAD(P) oxidoreductase
-
-
-
-
3alphaHSD
-
-
3alphaHSD
-
-
-
3alphaHSD
-
-
A-specific 3alpha-hydroxysteroid dehydrogenase
-
-
-
-
AKR1C2
P52895
-
AKR1C4
-
-
AKR1C9
P23457
-
alpha-HSD/CR
-
-
B-specific 3alpha-hydroxysteroid dehydrogenase
-
-
-
-
bile acid-binding protein
P52895
-
DD2
P52895
-
dihydrodiol dehydrogenase
P23457
-
NAD+-dependent 3alpha-HSD
-
-
NADP(H)-dependent 3alpha-HSD
-
-
type 2 3alpha-hydroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase
-
-
type 3 3-alpha-hydroxysteroid dehydrogenase
P52895
-
type 3 3alpha-HSD
P52895
-
type 3 3alpha-hydroxysteroid dehydrogenase
-
-
type 5 beta-hydroxysteroid dehydrogenase
P42330
-
additional information
-
cf. EC 1.1.1.50
additional information
-
cf. EC 1.1.1.50, the enzyme belongs to the short chain dehydrogenase/reductase protein superfamily
additional information
-
the enzyme belongs to the short-chain dehydrogenase/reductase family
additional information
-
cf. EC 1.1.1.239, the enzyme belongs to the AKR1C subfamily
additional information
-
cf. EC 1.1.1.50
additional information
-
cf. EC 1.1.1.50, the enzyme belongs to the aldo-keto reductase subfamily AKR1C
additional information
-
cf. EC 1.1.1.50, the enzyme belongs to the aldo-keto reductase, AKR, superfamily
additional information
P52895
the enzyme is a member of the aldo-keto reductase family
additional information
-
cf. EC 1.1.1.50, the enzyme belongs to the AKR1C family
additional information
-
cf. EC 1.1.1.50, the enzyme belongs to the AKR1C family
-
additional information
-
cf. EC 1.1.1.50
additional information
-
cf. EC 1.1.1.50, the enzyme belongs to the short-chain dehydrogenase/reductase family
additional information
-
cf. EC 1.1.1.50, the enzyme is a member of the aldo-keto reductase superfamily
additional information
-
see also EC 1.1.1.50, 3alpha-hydroxysteroid dehydrogenase (B-specific), for enzymes catalyzing the same reaction, but which are B-specific with respect to hydrogen transfer to/from NAD(P)+/NAD(P)H. Enzymes without information of stereospecificity are summarized under EC 1.1.1.50, but may in fact belong to EC 1.1.1.213
additional information
P23457
the enzyme belongs to the aldo-keto reductase gene family
CAS REGISTRY NUMBER
COMMENTARY
9028-56-2
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
strain VPI 12708
-
-
Manually annotated by BRENDA team
Eubacterium sp. VPI 12708
strain VPI 12708
-
-
Manually annotated by BRENDA team
gene AKR1C2 or DDH2
SwissProt
Manually annotated by BRENDA team
golden hamster, adult, male
-
-
Manually annotated by BRENDA team
strain B-0831
-
-
Manually annotated by BRENDA team
strain B-0831
-
-
Manually annotated by BRENDA team
female Wistar rats
-
-
Manually annotated by BRENDA team
isozyme AKR1C9
-
-
Manually annotated by BRENDA team
male sprague-dawley rats
-
-
Manually annotated by BRENDA team
male Wistar rats
-
-
Manually annotated by BRENDA team
male, adult; Sprangue-Dawley
-
-
Manually annotated by BRENDA team
male; Sprangue-Dawley
-
-
Manually annotated by BRENDA team
Sprangue-Dawley
-
-
Manually annotated by BRENDA team
Wistar, 7-13 weeks old
-
-
Manually annotated by BRENDA team
Rattus norvegicus Sprangue-Dawley
Sprangue-Dawley
-
-
Manually annotated by BRENDA team
TEMPERATURE STABILITY
TEMPERATURE STABILITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
45
-
-
50% inactivation after 17 min
45
-
-
inactivated in absence of ligand, protected only by the addition of NADP+