BRENDA - Enzyme Database show
show all sequences of 1.1.1.213

Tissue distribution of human AKR1C3 and rat homolog in adult genitourinary system

Azzarello, J.; Fung, K.M.; Lin, H.K.; J. Histochem. Cytochem. 56, 853-861 (2008)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
overexpression of AKR1C9 in Escherichia coli
Rattus norvegicus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytoplasm
-
Homo sapiens
5737
-
cytoplasm
-
Rattus norvegicus
5737
-
additional information
tissue-dependent subcellular localization, overview
Homo sapiens
-
-
additional information
tissue-dependent subcellular localization, overview
Rattus norvegicus
-
-
nucleus
-
Homo sapiens
5634
-
nucleus
-
Rattus norvegicus
5634
-
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
37000
-
x * 37000, SDS-PAGE
Rattus norvegicus
74000
75000
native PAGE, kidney enzyme
Rattus norvegicus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
additional information
Homo sapiens
AKR1C3 catalyzes androgen, estrogen, and prostaglandin metabolism, AKR1C3 is also involved in cancer development or progression
?
-
-
-
additional information
Rattus norvegicus
AKR1C9 catalyzes androgen, estrogen, and prostaglandin metabolism
?
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
male sprague-dawley rats
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
bladder
the urothelial epithelium lining the renal pelvis is strongly immunoreactive, but stromal cells in the underlying supporting connective tissue are negative
Homo sapiens
-
bladder
-
Rattus norvegicus
-
epididymis
only a small number of epithelial cells are immunoreactive with both nuclear and cytoplasmic reactivity
Homo sapiens
-
epididymis
no activity in the stromal cells or endothelial cells, but weak immunoreactivity in the epididymal epithelial cells
Rattus norvegicus
-
epithelial cell
-
Homo sapiens
-
epithelial cell
-
Rattus norvegicus
-
kidney
in renal cortex, endothelial cells of the glomeruli lack immunoreactivity for AKR1C3, but the Bowmans capsule and mesangial cells are strongly reactive, as well as larger epithelial cells of the medulla, overview
Homo sapiens
-
kidney
-
Rattus norvegicus
-
additional information
tissue distribution of AKR1C3, immunohistochemic analysis, overview
Homo sapiens
-
additional information
tissue distribution of AKR1C9, immunohistochemic analysis, overview
Rattus norvegicus
-
prostate
-
Homo sapiens
-
prostate gland
epithelial cells, but not the stromal cells or endothelial cells
Rattus norvegicus
-
testis
in Leydig cells, but no or poor activity in germ cells and Sertoli cells
Homo sapiens
-
testis
-
Rattus norvegicus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
additional information
AKR1C3 catalyzes androgen, estrogen, and prostaglandin metabolism, AKR1C3 is also involved in cancer development or progression
688137
Homo sapiens
?
-
-
-
-
additional information
AKR1C9 catalyzes androgen, estrogen, and prostaglandin metabolism
688137
Rattus norvegicus
?
-
-
-
-
Subunits
Subunits
Commentary
Organism
?
x * 37000, SDS-PAGE
Rattus norvegicus
Cloned(Commentary) (protein specific)
Commentary
Organism
overexpression of AKR1C9 in Escherichia coli
Rattus norvegicus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytoplasm
-
Homo sapiens
5737
-
cytoplasm
-
Rattus norvegicus
5737
-
additional information
tissue-dependent subcellular localization, overview
Homo sapiens
-
-
additional information
tissue-dependent subcellular localization, overview
Rattus norvegicus
-
-
nucleus
-
Homo sapiens
5634
-
nucleus
-
Rattus norvegicus
5634
-
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
37000
-
x * 37000, SDS-PAGE
Rattus norvegicus
74000
75000
native PAGE, kidney enzyme
Rattus norvegicus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
additional information
Homo sapiens
AKR1C3 catalyzes androgen, estrogen, and prostaglandin metabolism, AKR1C3 is also involved in cancer development or progression
?
-
-
-
additional information
Rattus norvegicus
AKR1C9 catalyzes androgen, estrogen, and prostaglandin metabolism
?
-
-
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
bladder
the urothelial epithelium lining the renal pelvis is strongly immunoreactive, but stromal cells in the underlying supporting connective tissue are negative
Homo sapiens
-
bladder
-
Rattus norvegicus
-
epididymis
only a small number of epithelial cells are immunoreactive with both nuclear and cytoplasmic reactivity
Homo sapiens
-
epididymis
no activity in the stromal cells or endothelial cells, but weak immunoreactivity in the epididymal epithelial cells
Rattus norvegicus
-
epithelial cell
-
Homo sapiens
-
epithelial cell
-
Rattus norvegicus
-
kidney
in renal cortex, endothelial cells of the glomeruli lack immunoreactivity for AKR1C3, but the Bowmans capsule and mesangial cells are strongly reactive, as well as larger epithelial cells of the medulla, overview
Homo sapiens
-
kidney
-
Rattus norvegicus
-
additional information
tissue distribution of AKR1C3, immunohistochemic analysis, overview
Homo sapiens
-
additional information
tissue distribution of AKR1C9, immunohistochemic analysis, overview
Rattus norvegicus
-
prostate
-
Homo sapiens
-
prostate gland
epithelial cells, but not the stromal cells or endothelial cells
Rattus norvegicus
-
testis
in Leydig cells, but no or poor activity in germ cells and Sertoli cells
Homo sapiens
-
testis
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
additional information
AKR1C3 catalyzes androgen, estrogen, and prostaglandin metabolism, AKR1C3 is also involved in cancer development or progression
688137
Homo sapiens
?
-
-
-
-
additional information
AKR1C9 catalyzes androgen, estrogen, and prostaglandin metabolism
688137
Rattus norvegicus
?
-
-
-
-
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 37000, SDS-PAGE
Rattus norvegicus
Other publictions for EC 1.1.1.213
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
724719
Matsunaga
Pathophysiological roles of al ...
Homo sapiens
Chem. Biol. Interact.
202
234-242
2013
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1
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1
1
1
724915
Heinrich
Synthesis and structure-activi ...
Homo sapiens
Eur. J. Med. Chem.
62
738-744
2013
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724916
Gazvoda
2,3-diarylpropenoic acids as s ...
Homo sapiens
Eur. J. Med. Chem.
62
89-97
2013
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1
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723866
Jackson
Structure of AKR1C3 with 3-phe ...
Homo sapiens
Acta Crystallogr. Sect. F
68
409-413
2012
-
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1
1
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1
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724533
Chen
Crystal structures of AKR1C3 c ...
Homo sapiens
Bioorg. Med. Chem. Lett.
22
3492-3497
2012
-
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1
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2
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1
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724538
Sinreih
N-Benzoyl anthranilic acid der ...
Homo sapiens
Bioorg. Med. Chem. Lett.
22
5948-5951
2012
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4
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4
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725153
Miller
Aldo-keto reductase family 1 m ...
Homo sapiens
Int. J. Clin. Exp. Pathol.
5
278-289
2012
-
1
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8
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725671
Brozic
Selective inhibitors of aldo-k ...
Homo sapiens
J. Med. Chem.
55
7417-7424
2012
-
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1
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2
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2
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1
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725825
Byrns
Overexpression of aldo-keto re ...
Homo sapiens
J. Steroid Biochem. Mol. Biol.
130
7-15
2012
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1
1
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724517
Adeniji
Discovery of substituted 3-(ph ...
Homo sapiens
Bioorg. Med. Chem. Lett.
21
1464-1468
2011
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725152
Zakharov
Suppressed expression of type ...
Homo sapiens
Int. J. Clin. Exp. Pathol.
3
608-617
2010
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1
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1
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1
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-
697265
Skarydova
AKR1C3 as a potential target f ...
Homo sapiens
Chem. Biol. Interact.
178
138-144
2009
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1
1
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15
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7
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7
15
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685529
Uwai
Electronic effects of para-sub ...
Rattus norvegicus
Bioorg. Med. Chem.
16
1084-1089
2008
-
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1
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8
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1
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1
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688137
Azzarello
Tissue distribution of human A ...
Homo sapiens, Rattus norvegicus
J. Histochem. Cytochem.
56
853-861
2008
-
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1
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-
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6
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2
2
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7
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14
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1
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6
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14
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2
1
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689169
Meyer
The biological activity of 3al ...
Rattus norvegicus
Neurobiol. Dis.
30
30-41
2008
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1
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697310
Shultz
Fjord-region benzo[g]chrysene- ...
Rattus norvegicus
Chem. Res. Toxicol.
21
668-677
2008
-
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1
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8
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2
2
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3
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1
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1
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2
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1
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1
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8
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2
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2
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1
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2
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1
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1
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684676
Sanai
Rat NAD+-dependent 3alpha-hydr ...
Rattus norvegicus
Arch. Biochem. Biophys.
464
122-129
2007
-
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1
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3
-
3
9
3
-
2
-
-
2
-
-
1
1
-
3
2
-
31
1
1
-
-
9
1
1
-
4
3
-
-
-
-
1
4
-
3
-
-
3
3
9
3
-
2
-
-
-
-
1
-
3
2
-
31
1
1
-
-
9
1
1
-
-
-
-
-
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-
687635
Cooper
Elucidation of a complete kine ...
Rattus norvegicus
J. Biol. Chem.
282
33484-33493
2007
-
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3
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1
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1
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1
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2
1
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687639
McCarthy
3-ketosteroid reductase activi ...
Rattus norvegicus
J. Biol. Chem.
282
34003-34012
2007
1
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1
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2
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2
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2
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2
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Understanding oligomerization ...
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Multiplicity of mammalian redu ...
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672088
Jin
Multiple steps determine the o ...
Homo sapiens
Biochemistry
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673349
Papari-Zareei
Arginine 276 controls the dire ...
Rattus norvegicus
Endocrinology
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1591-1597
2006
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673967
Rani
Discrete analysis of bile acid ...
Comamonas testosteroni
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Okochi
Enhanced activity of 3alpha-hy ...
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Tibolone metabolism in human l ...
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Wiebe
Dutasteride affects progestero ...
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Isolation and characterization ...
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Bauman
Identification of the major ox ...
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2006
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Yee
Fluorogenic metabolic probes f ...
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Mechanistic roles of Ser-114, ...
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Uwai
Purification and characterizat ...
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677001
Couture
Comparison of crystal structur ...
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Heredia
Dissection of the physiologica ...
Rattus norvegicus
Biochemistry
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Heredia
Alanine scanning mutagenesis o ...
Rattus norvegicus
Biochemistry
43
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Mutation of nicotinamide pocke ...
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Penning
Structure and function of 3alp ...
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3alpha-Hydroxysteroid oxidored ...
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Characterization of the substr ...
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Expression in Escherichia coli ...
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The kinetic mechanism catalyse ...
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Cloning and sequencing of the ...
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Demonstration of 3alpha(17beta ...
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Evidence that enzyme-generated ...
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A mammalian 3alpha-hydroxyster ...
Rattus norvegicus
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