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Literature summary for 1.1.1.213 extracted from

  • Penning, T.M.; Sharp, R.B
    Prostaglandin dehydrogenase activity of purified rat liver 3alpha-hydroxysteroid dehydrogenase (1987), Biochem. Biophys. Res. Commun., 148, 646-652.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
arachidonic acid
-
Rattus norvegicus
indomethacin
-
Rattus norvegicus
non-steroidal anti-inflamatory drug
-
Rattus norvegicus
Prostaglandin A2alpha Rattus norvegicus
prostaglandin A2alpha
-
Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0001
-
Prostaglandin
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Rattus norvegicus 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
34000
-
-
Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
CaCl2 and ammonium sulfate fractionation, DEAE-cellulose- and hydroxyapatite chromatography, chromatofocusing, Sephadex G-100 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0005 0.0053 for prostaglandins A1, A2, B1, B2, D2, E1, E2, F1, F2alpha at concentrations of 0.06 mM Rattus norvegicus
0.0007 0.0012 for 15-keto-prostaglandins E2 and F2alpha at concentrations of 0.06 mM Rattus norvegicus
2
-
for androsterone Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information oxidation of 3alpha-hydroxysteroids, secondary alcohols and trans-dihydrodiol proximate carcinogens derived from polycyclic aromatic hydrocarbons, reduction of quinones, aromatic aldehydes and ketones, 9-, 11-, and 15-hydroxyprostaglandin dehydrogenase activity of enzyme Rattus norvegicus ?
-
?
prostaglandin + NADP+ types A1, A2, B1, B2, D2, E1, E2, F1, F2alpha and 15-keto-prostaglandinE2 and F2alpha Rattus norvegicus ? + NADPH
-
?
prostaglandin-F2alpha + NADP+
-
Rattus norvegicus prostaglandin F2 + prostaglandin B2 + NADPH
-
?

Subunits

Subunits Comment Organism
monomer
-
Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.001
-
indomethacin
-
Rattus norvegicus
0.003
-
prostaglandin A2alpha
-
Rattus norvegicus
0.006
-
arachidonic acid
-
Rattus norvegicus