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Literature summary for 1.1.1.213 extracted from

  • Span, P.N.; Sweep, C.G.J.; Benraad, T.J.; Smals, A.G.H.
    3alpha-Hydroxysteroid oxidoreductase activities in dihydrotestosterone degradation and back-formation in rat prostate and epididymis (1996), J. Steroid Biochem. Mol. Biol., 58, 319-324.
    View publication on PubMed
Search for more literature for 1.1.1.213

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.505
-
 17beta-hydroxy-5alpha-androstan-3-one NAD(H), prostate Rattus norvegicus
0.614
-
 17beta-hydroxy-5alpha-androstan-3-one NADP(H), prostate Rattus norvegicus
0.645
-
 17beta-hydroxy-5alpha-androstan-3-one NADP(H), epididymis Rattus norvegicus
0.726
-
 17beta-hydroxy-5alpha-androstan-3-one NAD(H), epididymis Rattus norvegicus
0.781
-
 5alpha-androstane-3alpha,17beta-diol NAD(H), prostate Rattus norvegicus
1.09
-
 5alpha-androstane-3alpha,17beta-diol NADP(H), prostate Rattus norvegicus
3.042
-
 5alpha-androstane-3alpha,17beta-diol NAD(H), epididymis Rattus norvegicus
7.331
-
 5alpha-androstane-3alpha,17beta-diol NADP(H), epididymis Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Rattus norvegicus 5737
-
nucleus
-
 Rattus norvegicus 5634
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 Wistar, 7-13 weeks old
-

Source Tissue

Source Tissue Comment Organism Textmining
epididymis
-
 Rattus norvegicus
-
prostate gland
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
17beta-hydroxy-5alpha-androstan-3-one + NAD(P)H the rate of dihydrotestosterone reduction over back-conversion is 2.4 and 5.9 for prostate and epididymis, respectively Rattus norvegicus 5alpha-androstane-3alpha,17beta-diol + NAD(P)+
-
 r

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NAD+ higher activity Rattus norvegicus
NADH higher activity Rattus norvegicus
NADP+ lower activity Rattus norvegicus
NADPH lower activity Rattus norvegicus