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6.3.2.8: UDP-N-acetylmuramate-L-alanine ligase

This is an abbreviated version!
For detailed information about UDP-N-acetylmuramate-L-alanine ligase, go to the full flat file.

Word Map on EC 6.3.2.8

Reaction

ATP
+
UDP-N-acetyl-alpha-D-muramate
 +
L-alanine
=
ADP
 +
phosphate
 +
UDP-N-acetyl-alpha-D-muramoyl-L-alanine

Synonyms

Alanine-adding enzyme, alr5065, L-Ala ligase, L-Alanine adding enzyme, Mur ligase, MurB/CVs, MurC, MurC ligase, MurC synthetase, Synthetase, uridine diphospho-N-acetylmuramoylalanine, UDP-acetylmuramoyl-L-alanine synthetase, UDP-MurNAc:L-Ala ligase, UDP-MurNAc:L-alanine ligase, UDP-N-acetylenolpyruvoylglucosamine reductase/UDP-N-acetylmuramate: L-alanine ligase, UDP-N-acetylmuramate-alanine ligase, UDP-N-acetylmuramate:L-alanine ligase, UDP-N-acetylmuramic acid L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase, UDP-N-acetylmuramoyl:L-alanine ligase, UDP-N-acetylmuramoylalanine synthetase, UDP-N-acetylmuramyl:L-alanine ligase, UNAM:Ala ligase, Uridine 5´-diphosphate-N-acetylmuramyl-L-alanine synthetase, Uridine diphosphate N-acetylmuramate:L-alanine ligase, Uridine diphospho-N-acetylmuramoylalanine synthetase, Uridine-diphosphate-N-acetylmuramate:L-alanine ligase

ECTree

     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.2 Acid—amino-acid ligases (peptide synthases)
                6.3.2.8 UDP-N-acetylmuramate-L-alanine ligase

IC50 Value

IC50 Value on EC 6.3.2.8 - UDP-N-acetylmuramate-L-alanine ligase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.001
(1-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]piperidin-2-yl)methanol
Pseudomonas aeruginosa
-
pH and temperature not specified in the publication
0.0000005 - 0.000002
(1R,2S)-1-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2,3-dihydro-1H-inden-2-ol
0.0000007 - 0.000012
(2R)-2-((4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)-3-cyclohexylpropan-1-ol
0.0000012 - 0.000015
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(2-methoxypyridin-4-yl)ethan-1-ol
0.000008 - 0.000057
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(3-chloropyridin-4-yl)ethan-1-ol
0.0000005 - 0.000004
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(3-fluorophenyl)ethan-1-ol
0.000007 - 0.00006
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(3-methyl-1,2-oxazol-5-yl)ethan-1-ol
0.000004 - 0.000021
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(4-methoxyphenyl)ethan-1-ol
0.000008 - 0.00004
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(pyridin-2-yl)ethan-1-ol
0.000009
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(pyridin-3-yl)ethan-1-ol
Pseudomonas aeruginosa
-
pH and temperature not specified in the publication
0.0000006
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-cyclohexylethan-1-ol
Pseudomonas aeruginosa
-
pH and temperature not specified in the publication
0.000001 - 0.000005
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethan-1-ol
0.0000007 - 0.000004
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl (2-aminoethyl)carbamate
0.000002 - 0.000003
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl (2-hydroxyethyl)carbamate
0.0000006 - 0.000005
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl (2R)-2-(aminomethyl)morpholine-4-carboxylate
0.000006 - 0.000052
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl hydroxycarbamate
0.000001 - 0.0000013
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl [(1,5-dihydroxy-4-oxo-1,4-dihydropyridin-2-yl)methyl]carbamate
0.000007 - 0.00006
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl [2-(3-oxopyrazolidin-1-yl)ethyl]carbamate
0.0000005 - 0.000003
(2R)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethyl [[(4S)-3-methyl-2-oxoimidazolidin-4-yl]methyl]carbamate
0.00001
(2R)-2-([4-[(5-tert-butyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-cyclohexylethan-1-ol
Pseudomonas aeruginosa
-
pH and temperature not specified in the publication
0.000008
(2R)-2-cyclohexyl-2-[(4-[[5-(propan-2-yl)-1H-pyrazol-3-yl]amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino]ethan-1-ol
Pseudomonas aeruginosa
-
pH and temperature not specified in the publication
0.000005
(2S)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-cyclohexylethan-1-ol
Pseudomonas aeruginosa
-
pH and temperature not specified in the publication
0.000008 - 0.000011
(2S)-2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-phenylethan-1-ol
0.00005
(2S)-2-cyclohexyl-2-([4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)ethan-1-ol
Pseudomonas aeruginosa
-
pH and temperature not specified in the publication
0.0001
(2S)-2-cyclohexyl-2-[(4-[[5-(propan-2-yl)-1H-pyrazol-3-yl]amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino]ethan-1-ol
Pseudomonas aeruginosa
-
pH and temperature not specified in the publication
0.027
(5Z)-5-([2-[(4-chlorobenzyl)sulfanyl]-5-nitrophenyl]methylidene)-2-thioxo-1,3-thiazolidin-4-one
Escherichia coli
-
pH 8.0, 37°C
0.018
(5Z)-5-([4-[(E)-2-phenylethenyl]phenyl]methylidene)-2-thioxo-1,3-thiazolidin-4-one
Escherichia coli
-
pH 8.0, 37°C
0.123
1H-indazole-3-carbohydrazide
Escherichia coli
-
pH 8.0, 37°C
0.000011 - 0.000101
2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-2-(oxan-4-yl)ethan-1-ol
0.000013 - 0.000188
2-([4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino)-3-methylbutan-1-ol
0.032
2-phenyl-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]-1,3-thiazole-5-carbohydrazide
Escherichia coli
-
pH 8.0, 37°C
0.03
3-bromo-N-(4-([2-(2-naphthylsulfonyl)hydrazono]methyl)phenyl)benzamide
Escherichia coli
-
pH 8.0, 37°C
0.0023
5-methyl-N-([4-(5-phenyl-1-benzofuran-2-yl)phenyl]sulfonyl)thiophene-2-carboxamide
Escherichia coli
-
Compound A, IC50 2.3 microM
0.027
N-(2-([2-(2-naphthylsulfonyl)hydrazono]methyl)phenyl)-4-nitrobenzamide
Escherichia coli
-
pH 8.0, 37°C
0.031
N-(4-([2-(2-naphthylsulfonyl)hydrazono]methyl)phenyl)-2-naphthamide
Escherichia coli
-
pH 8.0, 37°C
0.051
N-(4-([2-(2-naphthylsulfonyl)hydrazono]methyl)phenyl)-2-nitrobenzamide
Escherichia coli
-
pH 8.0, 37°C