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Literature summary for 6.3.2.8 extracted from

  • Ehmann, D.E.; Demeritt, J.E.; Hull, K.G.; Fisher, S.L.
    Biochemical characterization of an inhibitor of Escherichia coli UDP-N-acetylmuramyl-L-alanine ligase (2004), BIOCHIM. BIOPHYS. ACTA, 1698, 167-174.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
5-methyl-N-([4-(5-phenyl-1-benzofuran-2-yl)phenyl]sulfonyl)thiophene-2-carboxamide IC50 2.3 microM Escherichia coli

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Escherichia coli 5737
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + UDP-N-acetylmuramate + L-alanine Escherichia coli
-
ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + UDP-N-acetylmuramate + L-alanine
-
Escherichia coli ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine
-
?

Synonyms

Synonyms Comment Organism
MurC
-
Escherichia coli

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0045
-
5-methyl-N-([4-(5-phenyl-1-benzofuran-2-yl)phenyl]sulfonyl)thiophene-2-carboxamide against ATP Escherichia coli
0.0063
-
5-methyl-N-([4-(5-phenyl-1-benzofuran-2-yl)phenyl]sulfonyl)thiophene-2-carboxamide against UDP-N-acetylmuramate Escherichia coli

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0023
-
Compound A, IC50 2.3 microM Escherichia coli 5-methyl-N-([4-(5-phenyl-1-benzofuran-2-yl)phenyl]sulfonyl)thiophene-2-carboxamide