6.3.2.8: UDP-N-acetylmuramate-L-alanine ligase

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For detailed information about UDP-N-acetylmuramate-L-alanine ligase, go to the full flat file.

Reaction

Synonyms

Alanine-adding enzyme, alr5065, L-Ala ligase, L-Alanine adding enzyme, Mur ligase, MurB/CVs, MurC, MurC ligase, MurC synthetase, Synthetase, uridine diphospho-N-acetylmuramoylalanine, UDP-acetylmuramoyl-L-alanine synthetase, UDP-MurNAc:L-Ala ligase, UDP-MurNAc:L-alanine ligase, UDP-N-acetylenolpyruvoylglucosamine reductase/UDP-N-acetylmuramate: L-alanine ligase, UDP-N-acetylmuramate-alanine ligase, UDP-N-acetylmuramate:L-alanine ligase, UDP-N-acetylmuramic acid L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase, UDP-N-acetylmuramoyl:L-alanine ligase, UDP-N-acetylmuramoylalanine synthetase, UDP-N-acetylmuramyl:L-alanine ligase, UNAM:Ala ligase, Uridine 5�-diphosphate-N-acetylmuramyl-L-alanine synthetase, Uridine diphosphate N-acetylmuramate:L-alanine ligase, Uridine diphospho-N-acetylmuramoylalanine synthetase, Uridine-diphosphate-N-acetylmuramate:L-alanine ligase

ECTree

     6 Ligases

         6.3 Forming carbon-nitrogen bonds

             6.3.2 Acid—amino-acid ligases (peptide synthases)

                6.3.2.8 UDP-N-acetylmuramate-L-alanine ligase

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Results	in table
7	Activating Compound
39030	AA Sequence
2	Application
1	CAS Registry Number
14	Cloned(Commentary)
13	Cofactor
6	Crystallization (Commentary)
24	General Information
4	General Stability
55	IC50 Value
189	Inhibitors
5	kcat/KM [mM/s]
4	Ki Value [mM]
77	KM Value [mM]
8	Localization
37	Metals/Ions
16	Molecular Weight [Da]
28	Natural Substrates/ Products (Substrates)
451	Organism
7	Pathway
55	PDB ID
15	pH Optimum
3	pH Range
1	pH Stability
1	Posttranslational Modification
21	Protein Variants
15	Purification (Commentary)
5	Reaction
2	Reaction Type
61	Reference
1	Source Tissue
5	Specific Activity [micromol/min/mg]
4	Storage Stability
122	Substrates and Products (Substrate)
8	Subunits
58	Synonyms
1	Systematic Name
10	Temperature Optimum [°C]
3	Temperature Stability [°C]
31	Turnover Number [1/s]

General Stability

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General Stability on EC 6.3.2.8 - UDP-N-acetylmuramate-L-alanine ligase

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GENERAL STABILITY

ORGANISM

UNIPROT

LITERATURE

decrease in stability at high salt concentrations is prevented by addition of 10% glycerol and 2.5 mM 2-mercaptoethanol

Staphylococcus aureus

-

1280

presence of 2-mercaptoethanol and glycerol is essential for stability

Escherichia coli

-

1288

relatively stable at low ionic strength, unstable at high concentrations of salt

Staphylococcus aureus

-

1280

stability is strictly dependent on the presence of 2-mercaptoethanol

Escherichia coli

-

1287