6.1.1.6: lysine-tRNA ligase

This is an abbreviated version!
For detailed information about lysine-tRNA ligase, go to the full flat file.

Word Map on EC 6.1.1.6

6.1.1.6

synthetases

aminoacylation

lysylation

anticodon

aarss

isoacceptors

diadenosine

aspartyl-trna

gagpol

tetraphosphate

trnalys3

prors

valrs

leurs

arginyl-trna

isoleucyl-trna

glnrs

atp-ppi

anticodon-binding

prolyl-trna

multi-trna

asprs

diagnostics

pharmacology

medicine

drug development

synthesis

Reaction

Synonyms

Ap4A synthase, BBA_03037, class 1 lysyl tRNA synthetase, class I LysRS, class I lysyl-tRNA synthetase, class II lysyl-tRNA synthetase, cyto-LysRS, cytoKARS, cytoplasmic lysyl-tRNA synthetase, FOSTERSO_4045, GsLysRS, hKRS, KARS, KRS, KRS-1, L-Lysine-transfer RNA ligase, lysine aminoacyl-tRNA synthetase, Lysine translase, Lysine--tRNA ligase, Lysine-tRNA synthetase, LysRS, LysRS-I, LysRS-II, LysRS1, LysRS2, lysS, lysS2, LysU, LysX, lysyl tRNA synthetase, Lysyl-transfer ribonucleate synthetase, Lysyl-transfer RNA synthetase, Lysyl-tRNA synthetase, lysylphosphatidylglycerol biosynthesis bifunctional protein, mito-LysRS, mitochondrial lysyl-tRNA synthetase, mitoKARS, More, Msk1p, MSMEG_3796, MSMEG_6094, MSMEI_3707, MXAN_4731, PF3D7_1350100, PfKRS, preMsk1p, Synthetase, lysyl-transfer ribonucleate, tRK1

ECTree

6 Ligases

6.1 Forming carbon-oxygen bonds

6.1.1 Ligases forming aminoacyl-tRNA and related compounds

6.1.1.6 lysine-tRNA ligase

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Results	in table
10	Activating Compound
51219	AA Sequence
7	Application
1	CAS Registry Number
47	Cloned(Commentary)
56	Cofactor
13	Crystallization (Commentary)
181	Disease/ Diagnostics
6	Expression
58	General Information
1	General Stability
9	IC50 Value
64	Inhibitors
3	kcat/KM [mM/s]
44	Ki Value [mM]
138	KM Value [mM]
53	Localization
27	Metals/Ions
38	Molecular Weight [Da]
64	Natural Substrates/ Products (Substrates)
728	Organism
4	Pathway
173	PDB ID
15	pH Optimum
1	pH Range
1	pH Stability
2	pI Value
9	Posttranslational Modification
99	Protein Variants
46	Purification (Commentary)
13	Reaction
46	Reaction Type
170	Reference
52	Source Tissue
15	Specific Activity [micromol/min/mg]
4	Storage Stability
251	Substrates and Products (Substrate)
32	Subunits
474	Synonyms
1	Systematic Name
17	Temperature Optimum [°C]
2	Temperature Range [°C]
6	Temperature Stability [°C]
130	Turnover Number [1/s]

Expression

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Expression on EC 6.1.1.6 - lysine-tRNA ligase

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enzyme depletion by KARS specific siRNA

Mus musculus

714671

the complex formation among KRS, p67LR, and integrins alpha6 and beta1 upon cell adhesion can be disrupted by YH16899 treatment. SW620 cells with inhibitors U1026 or YH16899 blocks dissemination. Blockade of dissemination of KRS-suppressed cells is relieved by ERK1/2 and/or paxillin expression

Homo sapiens

Q15046

745940

the Krs gene BBA_03037 is upregulated in the host infection of Beauveria bassiana

2 entries

the T box element associated with LysRS1 can be partially induced by asparagine starvation

2 entries