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Reference on EC 6.1.1.6 - lysine-tRNA ligase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Dickman, S.R.; Boll, D.J.
Differential purification of methionine-tRNA synthetase and lysine-tRNA synthetase from rabbit liver
Biochem. Biophys. Res. Commun.
78
1191-1197
1977
Oryctolagus cuniculus
Manually annotated by BRENDA team
Samuelsson, T.; Lundvik, L.
Purification and some properties of asparagine, lysine, serine, and valine:tRNA ligases from Bacillus stearothermophilus
J. Biol. Chem.
253
7033-7039
1978
Geobacillus stearothermophilus
Manually annotated by BRENDA team
Norcum, M.T.
Isolation and electron microscopic characterization of the high molecular mass aminoacyl-tRNA synthetase complex from murine erythroleukemia cells
J. Biol. Chem.
264
15043-15051
1989
Mus musculus
Manually annotated by BRENDA team
Sivaram, P.; Vellekamp, G.; Deutscher, M.P.
A role for lipids in the functional and structural properties of the rat liver aminoacyl-tRNA synthetase complex
J. Biol. Chem.
263
18891-18896
1988
Rattus norvegicus
Manually annotated by BRENDA team
Freist, W.; Sternbach, H.; von der Haar, F.; Cramer, F.
Threonyl-tRNA, lysyl-tRNA and arginyl-tRNA synthetases from baker's yeast. Substrate specificity with regard to ATP analogues
Eur. J. Biochem.
84
499-502
1978
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Airas, R.K.
Differences in the magnesium dependences of the class I and class II aminoacyl-tRNA synthetases from Escherichia coli
Eur. J. Biochem.
240
223-231
1996
Escherichia coli
Manually annotated by BRENDA team
Cirakoglu, B.; Waller, J.P.
Leucyl-tRNA and lysyl-tRNA synthetases, derived from the high-Mr complex of sheep liver, are hydrophobic proteins
Eur. J. Biochem.
151
101-110
1985
Ovis aries
Manually annotated by BRENDA team
Takita, T.; Ohkubo, Y.; Shima, H.; Muto, T.; Shimizu, N.; Sukata, H.; Ito, Y.; Saito, Y.; Inouye, K.; Hiromi, K.; Tonomura, B.
Lysyl-tRNA synthetase from Bacillus stearothermophilus. Purification and fluorometric and kinetic analysis of the binding of substrates, L-lysine and ATP
J. Biochem.
119
680-689
1996
Geobacillus stearothermophilus, Geobacillus stearothermophilus NCA1503
Manually annotated by BRENDA team
Freist, W.; Sternbach, H.; Cramer, F.
Lysyl-tRNA synthetase from yeast. Discrimination of amino acids by native and phosphorylated species
Eur. J. Biochem.
204
1015-1023
1992
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Cusack, S.; Yaremchuk, A.; Tukalo, M.
The crystal structures of T. thermophilus lysyl-tRNA synthetase complexed with E. coli tRNALys and a T. thermophilus tRNALys transcript: anticodon recognition and conformational changes upon binding of a lysyl-adenylate analogue
EMBO J.
15
6321-6334
1996
Thermus thermophilus
Manually annotated by BRENDA team
Onesti, S.; Miller, A.D.; Brick, P.
The crystal structure of the lysyl-tRNA synthetase from Escherichia coli
Structure
15
163-176
1995
Escherichia coli
Manually annotated by BRENDA team
Jakubowski, H.
The plant aminoacyl-tRNA synthetases. 2'-DeoxyATP and ATP in reactions catalysed by yellow lupin aminoacyl-tRNA synthetase
Acta Biochim. Pol.
27
321-333
1980
Lupinus luteus
Manually annotated by BRENDA team
Hele, P.; Barber, R.
Lysyl tRNA synthetase of Escherichia coli. Formation and reactions of ATP-enzyme and lysyl-AMP-enzyme complexes
Biochim. Biophys. Acta
258
319-331
1972
Escherichia coli, Escherichia coli B / ATCC 11303
Manually annotated by BRENDA team
Kisselev, L.L.; Baturina, I.D.
Two enzymatically active forms of lysyl-tRNA synthetase from E. coli B
FEBS Lett.
22
231-234
1972
Escherichia coli, Escherichia coli B / ATCC 11303
Manually annotated by BRENDA team
Baturina, I.D.; Gnutchev, N.V.; Khomutov, R.M.; Kisselev, L.L.
Substrate specificity of lysyl-tRNA synthetase from E. coli B
FEBS Lett.
22
235-237
1972
Escherichia coli, Escherichia coli B / ATCC 11303
Manually annotated by BRENDA team
sterberg, R.; Sjberg, B.; Rymo, L.; Lagerkvist, U.
Small-angle scattering study of lysine transfer RNA ligase from yeast
J. Mol. Biol.
77
153-158
1973
Saccharomyces cerevisiae, Saccharomyces cerevisiae C836
Manually annotated by BRENDA team
Goto, T.; Schweiger, A.
Lysyl-tRNA synthetase from rat liver. Partial purification and evidence that this enzyme is associated with arginyl-tRNA synthetase
Hoppe-Seyler's Z. Physiol. Chem.
354
1027-1033
1973
Rattus norvegicus
Manually annotated by BRENDA team
Moline, G.; Hampel, A.; Enger, M.D.
Polyribosomal and particulate distribution of lysyl- and phenylalanyl-transfer ribonucleic acid synthetases
Biochem. J.
143
191-195
1974
Cricetulus griseus
Manually annotated by BRENDA team
Dittgen, R.M.; Leberman, R.
Multiple forms of lysyl-tRNA synthetase from Escherichia coli
Hoppe-Seyler's Z. Physiol. Chem.
357
543-551
1976
Escherichia coli, Escherichia coli MRE 600
Manually annotated by BRENDA team
Johnson, D.L.; Dang, C.V.; Yang, D.C.H.
Purification and characterization of lysyl-tRNA synthetase after dissociation of the particulate aminoacyl-tRNA synthetases from rat liver
J. Biol. Chem.
255
4362-4366
1980
Rattus norvegicus
Manually annotated by BRENDA team
Glinski, R.L.; Gainey, P.C.; Mawhinney, T.P.; Hilderman, R.H.
Evidence that lysyl- and/or arginyl-tRNA synthetases from rat liver contain carbohydrate
Biochem. Biophys. Res. Commun.
88
1052-1061
1979
Rattus norvegicus
Manually annotated by BRENDA team
Freist, W.; Cramer, F.
Phenylalanyl-tRNA, lysyl-tRNA, isoleucyl-tRNA and arginyl-tRNA synthetases. Substrate specificity in the ATP-diphosphate exchange with regard to ATP analogs
Eur. J. Biochem.
107
47-50
1980
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Dang, C.V.
High molecular weight complex formation of rat liver lysyl-tRNA synthetase reduces enzyme lability to thermal inactivation
Biochem. Biophys. Res. Commun.
106
44-47
1982
Rattus norvegicus
Manually annotated by BRENDA team
Van Dang, C.; Mawhinney, T.P.; Hilderman, R.H.
Characterization of a homogeneous arginyl- and lysyl-tRNA synthetase complex isolated from rat liver. Arginyl- and lysyl-tRNA synthetases contain carbohydrates
Biochemistry
21
4891-4895
1982
Rattus norvegicus
Manually annotated by BRENDA team
Plateau, P.; Blanquet, S.
Zinc-dependent synthesis of various dinucleoside 5', 5'''-P1, P3-tri or 5', 5'''-P1,P4-tetraphosphates by Escherichia coli lysyl-tRNA synthetase
Biochemistry
21
5273-5279
1982
Escherichia coli
Manually annotated by BRENDA team
Hilderman, R.H.
Characterization of a homogeneous complex of arginyl- and lysyl-tRNA synthetase. Zinc and adenosine 5'-phosphate dependent synthesis of diadenosine 5',5'''-P1,P4-tetraphosphate
Biochemistry
22
4353-4357
1983
Rattus norvegicus
Manually annotated by BRENDA team
Hilderman, R.H.; Zimmerman, J.K.; Dang, C.V.; Grothusen, J.R.
Characterization of a homogeneous arginyl- and lysyl-tRNA synthetase complex isolated from rat liver
J. Biol. Chem.
258
13592-13596
1983
Rattus norvegicus
Manually annotated by BRENDA team
Wahab, S.Z.; Yang, D.C.H.
Influence of supramolecular structure on the enzyme mechanism of rat liver lysyl-tRNA synthetase-catalyzed reactions
J. Biol. Chem.
260
12735-12739
1985
Rattus norvegicus
Manually annotated by BRENDA team
Wahab, S.Z.; Yang, D.C.H.
Comparison of the enzymatic behavior of high molecular weight and free lysyl-tRNA synthetase from rat liver. Kinetic analysis of lysylation of tRNA
Arch. Biochem. Biophys.
249
407-417
1986
Rattus norvegicus
Manually annotated by BRENDA team
Madan Kumar, A.; Nayak, R.
Rapid isolation of lysyl-tRNA synthetase from rat liver
Biochem. Biophys. Res. Commun.
152
593-597
1988
Rattus norvegicus
Manually annotated by BRENDA team
Shiba, K.
Human lysyl-tRNA synthetase accepts nucleotide 73 variants and rescues E. coli double defection mutant
J. Biol. Chem.
272
22809-22816
1997
Homo sapiens
Manually annotated by BRENDA team
Jakubowski, H.
Misacylation of tRNALys with noncognate amino acids by lysyl-tRNA synthetase
Biochemistry
38
8088-8093
1999
Escherichia coli
Manually annotated by BRENDA team
Onesti, S.; Desogus, G.; Brevet, A.; Chen, J.; Plateau, P.; Blanquet, S.; Brick, P.
Structural studies of lysyl-tRNA synthetase: conformational changes induced by substrate binding
Biochemistry
39
12853-12861
2000
Escherichia coli (P0A8N3), Escherichia coli
Manually annotated by BRENDA team
Takita, T.; Shimizu, N.; Sukata, T.; Hashimoto, S.; Akita, E.; Yokota, T.; Esaki, N.; Soda, K.; Inouye, K.; Tonomura, B.i.
Lysyl-tRNA synthetase of Bacillus stearothermophilus:molecular cloning and expression of the gene
Biosci. Biotechnol. Biochem.
64
432-437
2000
Geobacillus stearothermophilus (Q9RHV9), Geobacillus stearothermophilus
Manually annotated by BRENDA team
Takita, T.; Akita, E.; Inouye, K.; Tonomura, B.i.
Lysyl-tRNA synthetase from Bacillus stearothermophilus. Stopped-flow kinetic analysis of enzyme.lysyladenylate formation
J. Biochem.
124
45-50
1998
Geobacillus stearothermophilus
Manually annotated by BRENDA team
Nathanson, L.; Deutscher, M.P.
Active aminoacyl-tRNA synthetases are present in nuclei as a high molecular weight multienzyme complex
J. Biol. Chem.
275
31559-31562
2000
Cricetulus griseus, Oryctolagus cuniculus
Manually annotated by BRENDA team
Tolkunova, E.; Park, H.; Xia, J.; King, M.P.; Davidson, E.
The human lysyl-tRNA synthetase gene encodes both the cytoplasmic and mitochondrial enzymes by means of an unusual alternative splicing of the primary transcript
J. Biol. Chem.
275
35063-35069
2000
Homo sapiens (Q15046), Homo sapiens
Manually annotated by BRENDA team
Francin, M.; Kaminska, M.; Kerjan, P.; Mirande, M.
The N-terminal domain of mammalian Lysyl-tRNA synthetase is a functional tRNA-binding domain
J. Biol. Chem.
277
1762-1769
2002
Cricetinae
Manually annotated by BRENDA team
Javanbakht, H.; Halwani, R.; Cen, S.; Saadatmand, J.; Musier-Forsyth, K.; Gottlinger, H.; Kleiman, L.
The interaction between HIV-1 Gag and human lysyl-tRNA synthetase during viral assembly
J. Biol. Chem.
278
27644-27651
2003
Homo sapiens
Manually annotated by BRENDA team
Levengood, J.D.; Ataide, S.F.; Roy, H.; Ibba, M.
Divergence in non-cognate amino acid recognition between class I and class II lysyl-tRNA synthetases
J. Biol. Chem.
279
17707-17714
2004
Borreliella burgdorferi, Escherichia coli
Manually annotated by BRENDA team
Takita, T.; Nakagoshi, M.; Inouye, K.; Tonomura, B.i.
Lysyl-tRNA synthetase from Bacillus stearothermophilus: The Trp314 residue is shielded in a non-polar environment and is responsible for the fluorescence changes observed in the amino acid activation reaction
J. Mol. Biol.
325
677-695
2003
Geobacillus stearothermophilus
Manually annotated by BRENDA team
Cen, S.; Khorchid, A.; Javanbakht, H.; Gabor, J.; Stello, T.; Shiba, K.; Musier-Forsyth, K.; Kleiman, L.
Incorporation of lysyl-tRNA synthetase into human immunodeficiency virus type 1
J. Virol.
75
5043-5048
2001
Homo sapiens
Manually annotated by BRENDA team
Terada, T.; Nureki, O.; Ishitani, R.; Ambrogelly, A.; Ibba, M.; Soll, D.; Yokoyama, S.
Functional convergence of two lysyl-tRNA synthetases with unrelated topologies
Nat. Struct. Biol.
9
257-262
2002
Pyrococcus horikoshii (O57963), Pyrococcus horikoshii
Manually annotated by BRENDA team
Stello, T.; Hong, M.; Musier-Forsyth, K.
Efficient aminoacylation of tRNALys,3 by human lysyl-tRNA synthetase is dependent on covalent continuity between the acceptor stem and the anticodon domain
Nucleic Acids Res.
27
4823-4829
1999
Homo sapiens
Manually annotated by BRENDA team
Ibba, M.; Losey, H.C.; Kawarabayasi, Y.; Kikuchi, H.; Bunjun, S.; Soll, D.
Substrate recognition by class I lysyl-tRNA synthetases: a molecular basis for gene displacement
Proc. Natl. Acad. Sci. USA
96
418-423
1999
Aeropyrum pernix (Q9YFT9), Borreliella burgdorferi, Escherichia coli, Methanococcus maripaludis
Manually annotated by BRENDA team
Soell, D.; Becker, H.D.; Plateau, P.; Blanquet, S.; Ibba, M.
Context-dependent anticodon recognition by class I lysyl-tRNA synthetases
Proc. Natl. Acad. Sci. USA
97
14224-14228
2000
Borreliella burgdorferi, Helicobacter pylori, Methanococcus maripaludis
Manually annotated by BRENDA team
Ataide, S.F.; Ibba, M.
Discrimination of cognate and noncognate substrates at the active site of class II lysyl-tRNA synthetase
Biochemistry
43
11836-11841
2004
Escherichia coli
Manually annotated by BRENDA team
Ambrogelly, A.; Frugier, M.; Ibba, M.; Soll, D.; Giege, R.
Transfer RNA recognition by class I lysyl-tRNA synthetase from the Lyme disease pathogen Borrelia burgdorferi
FEBS Lett.
579
2629-2634
2005
Borreliella burgdorferi
Manually annotated by BRENDA team
Lee, Y.N.; Nechushtan, H.; Figov, N.; Razin, E.
The function of lysyl-tRNA synthetase and Ap4A as signaling regulators of MITF activity in FcepsilonRI-activated mast cells
Immunity
20
145-151
2004
Homo sapiens
Manually annotated by BRENDA team
Guo, F.; Gabor, J.; Cen, S.; Hu, K.; Mouland, A.J.; Kleiman, L.
Inhibition of cellular HIV-1 protease activity by lysyl-tRNA synthetase
J. Biol. Chem.
280
26018-26023
2005
Homo sapiens
Manually annotated by BRENDA team
Cen, S.; Javanbakht, H.; Niu, M.; Kleiman, L.
Ability of wild-type and mutant lysyl-tRNA synthetase to facilitate tRNA(Lys) incorporation into human immunodeficiency virus type 1
J. Virol.
78
1595-1601
2004
Homo sapiens
Manually annotated by BRENDA team
Halwani, R.; Cen, S.; Javanbakht, H.; Saadatmand, J.; Kim, S.; Shiba, K.; Kleiman, L.
Cellular distribution of Lysyl-tRNA synthetase and its interaction with Gag during human immunodeficiency virus type 1 assembly
J. Virol.
78
7553-7564
2004
Homo sapiens
Manually annotated by BRENDA team
Park, S.G.; Kim, H.J.; Min, Y.H.; Choi, E.C.; Shin, Y.K.; Park, B.J.; Lee, S.W.; Kim, S.
Human lysyl-tRNA synthetase is secreted to trigger proinflammatory response
Proc. Natl. Acad. Sci. USA
102
6356-6361
2005
Homo sapiens
Manually annotated by BRENDA team
Sissler, M.; Helm, M.; Frugier, M.; Giege, R.; Florentz, C.
Aminoacylation properties of pathology-related human mitochondrial tRNA(Lys) variants
RNA
10
841-853
2004
Homo sapiens
Manually annotated by BRENDA team
Francin, M.; Mirande, M.
Identity elements for specific aminoacylation of a tRNA by mammalian lysyl-tRNA synthetase bearing a nonspecific tRNA-interacting factor
Biochemistry
45
10153-10160
2006
Mesocricetus auratus
Manually annotated by BRENDA team
Wang, S.; Praetorius-Ibba, M.; Ataide, S.F.; Roy, H.; Ibba, M.
Discrimination of cognate and noncognate substrates at the active site of class I lysyl-tRNA synthetase
Biochemistry
45
3646-3652
2006
Borreliella burgdorferi
Manually annotated by BRENDA team
Levengood, J.D.; Roy, H.; Ishitani, R.; Soell, D.; Nureki, O.; Ibba, M.
Anticodon recognition and discrimination by the alpha-helix cage domain of class I lysyl-tRNA synthetase
Biochemistry
46
11033-11038
2007
Pyrococcus horikoshii
Manually annotated by BRENDA team
Rao, V.R.; Ramanjeneyulu, R.; Rao, D.M.; Kumar, C.S.
Comparative modeling of class 1 lysyl tRNA synthetase from Treponema pallidum
Bioinformation
1
81-82
2006
Treponema pallidum (O83650), Treponema pallidum
Manually annotated by BRENDA team
Shaul, S.; Nussinov, R.; Pupko, T.
Paths of lateral gene transfer of lysyl-aminoacyl-tRNA synthetases with a unique evolutionary transition stage of prokaryotes coding for class I and II varieties by the same organisms
BMC Evol. Biol.
6
22
2006
Aeropyrum pernix, Agrobacterium tumefaciens, Borreliella burgdorferi, Brucella melitensis, Brucella suis, Caulobacter vibrioides, Cenarchaeum symbiosum, Cereibacter sphaeroides, Magnetospirillum magnetotacticum, Mesorhizobium loti, Methanosarcina acetivorans, Methanosarcina barkeri, Methanosarcina mazei, Mycobacterium leprae, Mycobacterium tuberculosis, Novosphingobium aromaticivorans, Pyrobaculum aerophilum, Rhodopseudomonas palustris, Rickettsia conorii, Rickettsia prowazekii, Saccharolobus solfataricus, Sinorhizobium meliloti, Streptomyces avermitilis, Streptomyces coelicolor, Treponema denticola, Treponema pallidum, Wolbachia sp.
Manually annotated by BRENDA team
Wright, M.; Boonyalai, N.; Tanner, J.A.; Hindley, A.D.; Miller, A.D.
The duality of LysU, a catalyst for both Ap4A and Ap3A formation
FEBS J.
273
3534-3544
2006
Escherichia coli
Manually annotated by BRENDA team
Kaminska, M.; Francin, M.; Shalak, V.; Mirande, M.
Role of HIV-1 Vpr-induced apoptosis on the release of mitochondrial lysyl-tRNA synthetase
FEBS Lett.
581
3105-3110
2007
Homo sapiens
Manually annotated by BRENDA team
Fukunaga, J.; Yokogawa, T.; Ohno, S.; Nishikawa, K.
Misacylation of yeast amber suppressor tRNA(Tyr) by E. coli lysyl-tRNA synthetase and its effective repression by genetic engineering of the tRNA sequence
J. Biochem.
139
689-696
2006
Escherichia coli
Manually annotated by BRENDA team
Kovaleski, B.J.; Kennedy, R.; Hong, M.K.; Datta, S.A.; Kleiman, L.; Rein, A.; Musier-Forsyth, K.
In vitro characterization of the interaction between HIV-1 Gag and human lysyl-tRNA synthetase
J. Biol. Chem.
281
19449-19456
2006
Homo sapiens
Manually annotated by BRENDA team
Chou, T.F.; Tikh, I.B.; Horta, B.A.; Ghosh, B.; De Alencastro, R.B.; Wagner, C.R.
Engineered monomeric human histidine triad nucleotide-binding protein 1 hydrolyzes fluorogenic acyl-adenylate and lysyl-tRNA synthetase-generated lysyl-adenylate
J. Biol. Chem.
282
15137-15147
2007
Homo sapiens
Manually annotated by BRENDA team
Kovaleski, B.J.; Kennedy, R.; Khorchid, A.; Kleiman, L.; Matsuo, H.; Musier-Forsyth, K.
Critical role of helix 4 of HIV-1 capsid C-terminal domain in interactions with human lysyl-tRNA synthetase
J. Biol. Chem.
282
32274-32279
2007
Homo sapiens
Manually annotated by BRENDA team
Praetorius-Ibba, M.; Hausmann, C.D.; Paras, M.; Rogers, T.E.; Ibba, M.
Functional association between three archaeal aminoacyl-tRNA synthetases
J. Biol. Chem.
282
3680-3687
2007
Methanothermobacter thermautotrophicus
Manually annotated by BRENDA team
Chou, T.F.; Wagner, C.R.
Lysyl-tRNA synthetase-generated lysyl-adenylate is a substrate for histidine triad nucleotide binding proteins
J. Biol. Chem.
282
4719-4727
2007
Escherichia coli, Homo sapiens
Manually annotated by BRENDA team
Kaminska, M.; Shalak, V.; Francin, M.; Mirande, M.
Viral hijacking of mitochondrial lysyl-tRNA synthetase
J. Virol.
81
68-73
2007
Homo sapiens
Manually annotated by BRENDA team
Yannay-Cohen, N.; Razin, E.
Translation and transcription: the dual functionality of LysRS in mast cells
Mol. Cell
22
127-132
2006
Homo sapiens
Manually annotated by BRENDA team
Mahapatra, A.; Srinivasan, G.; Richter, K.B.; Meyer, A.; Lienard, T.; Zhang, J.K.; Zhao, G.; Kang, P.T.; Chan, M.; Gottschalk, G.; Metcalf, W.W.; Krzycki, J.A.
Class I and class II lysyl-tRNA synthetase mutants and the genetic encoding of pyrrolysine in Methanosarcina spp.
Mol. Microbiol.
64
1306-1318
2007
Methanosarcina acetivorans, Methanosarcina barkeri (Q9C4B9), Methanosarcina barkeri, Methanosarcina barkeri MS / DSM 800 (Q9C4B9)
Manually annotated by BRENDA team
Fukunaga, J.; Ohno, S.; Nishikawa, K.; Yokogawa, T.
A base pair at the bottom of the anticodon stem is reciprocally preferred for discrimination of cognate tRNAs by Escherichia coli lysyl- and glutaminyl-tRNA synthetases
Nucleic Acids Res.
34
3181-3188
2006
Escherichia coli
Manually annotated by BRENDA team
Wu, X.R.; Kenzior, A.; Willmot, D.; Scanlon, S.; Chen, Z.; Topin, A.; He, S.H.; Acevedo, A.; Folk, W.R.
Altered expression of plant lysyl tRNA synthetase promotes tRNA misacylation and translational recoding of lysine
Plant J.
50
627-636
2007
Arabidopsis thaliana
Manually annotated by BRENDA team
Guzzo, C.M.; Yang, D.C.
Lysyl-tRNA synthetase interacts with EF1alpha, aspartyl-tRNA synthetase and p38 in vitro
Biochem. Biophys. Res. Commun.
365
718-723
2008
Homo sapiens (Q15046), Homo sapiens
Manually annotated by BRENDA team
Saruwatari, Y.; Wada, T.; Takita, T.; Inouye, K.
Substrate-induced conformational changes of the truncated catalytic domain of Geobacillus stearothermophilus lysyl-tRNA synthetase as examined by fluorescence
Biochim. Biophys. Acta
1784
1633-1640
2008
Geobacillus stearothermophilus (Q9RHV9), Geobacillus stearothermophilus
Manually annotated by BRENDA team
Kawamata, H.; Magrane, J.; Kunst, C.; King, M.P.; Manfredi, G.
Lysyl-tRNA synthetase is a target for mutant SOD1 toxicity in mitochondria
J. Biol. Chem.
283
28321-28328
2008
Homo sapiens (Q15046)
Manually annotated by BRENDA team
Farrera-Sinfreu, J.; Espanol, Y.; Geslain, R.; Guitart, T.; Albericio, F.; Ribas de Pouplana, L.; Royo, M.
Solid-phase combinatorial synthesis of a lysyl-tRNA synthetase (LysRS) inhibitory library
J. Comb. Chem.
10
391-400
2008
Trypanosoma brucei (Q580G3), Trypanosoma brucei
Manually annotated by BRENDA team
Meerschaert, K.; Remue, E.; De Ganck, A.; Staes, A.; Boucherie, C.; Gevaert, K.; Vandekerckhove, J.; Kleiman, L.; Gettemans, J.
The Tandem PDZ Protein Syntenin Interacts with the Aminoacyl tRNA Synthetase Complex in a Lysyl-tRNA Synthetase-Dependent Manner
J. Proteome Res.
7
4962-4973
2008
Homo sapiens (Q15046)
Manually annotated by BRENDA team
Wei, M.; Yang, Y.; Niu, M.; Desfosse, L.; Kennedy, R.; Musier-Forsyth, K.; Kleiman, L.
Inability of HIV-1 produced in murine cells to selectively incorporate primer tRNALys3
J. Virol.
82
12049-12059
2008
Homo sapiens (Q15046), Homo sapiens, Mus musculus (Q99MN1), Mus musculus
Manually annotated by BRENDA team
Guo, M.; Ignatov, M.; Musier-Forsyth, K.; Schimmel, P.; Yang, X.L.
Crystal structure of tetrameric form of human lysyl-tRNA synthetase: Implications for multisynthetase complex formation
Proc. Natl. Acad. Sci. USA
105
2331-2336
2008
Homo sapiens (Q15046), Homo sapiens
Manually annotated by BRENDA team
Saadatmand, J.; Guo, F.; Cen, S.; Niu, M.; Kleiman, L.
Interactions of reverse transcriptase sequences in Pol with Gag and LysRS in the HIV-1 tRNALys3 packaging/annealing complex
Virology
380
109-117
2008
Homo sapiens
Manually annotated by BRENDA team
Sakurama, H.; Takita, T.; Mikami, B.; Itoh, T.; Yasukawa, K.; Inouye, K.
Two crystal structures of lysyl-tRNA synthetase from Bacillus stearothermophilus in complex with lysyladenylate-like compounds: insights into the irreversible formation of the enzyme-bound adenylate of L-lysine hydroxamate
J. Biochem.
145
555-563
2009
Geobacillus stearothermophilus (Q9RHV9), Geobacillus stearothermophilus
Manually annotated by BRENDA team
Kamenski, P.; Smirnova, E.; Kolesnikova, O.; Krasheninnikov, I.A.; Martin, R.P.; Entelis, N.; Tarassov, I.
tRNA mitochondrial import in yeast: Mapping of the import determinants in the carrier protein, the precursor of mitochondrial lysyl-tRNA synthetase
Mitochondrion
10
284-293
2010
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Yannay-Cohen, N.; Carmi-Levy, I.; Kay, G.; Yang, C.M.; Han, J.M.; Kemeny, D.M.; Kim, S.; Nechushtan, H.; Razin, E.
LysRS serves as a key signaling molecule in the immune response by regulating gene expression
Mol. Cell
34
603-611
2009
Homo sapiens
Manually annotated by BRENDA team
Foy, N.; Jester, B.; Conant, G.C.; Devine, K.M.
The T box regulatory element controlling expression of the class I lysyl-tRNA synthetase of Bacillus cereus strain 14579 is functional and can be partially induced by reduced charging of asparaginyl-tRNAAsn
BMC Microbiol.
10
196
2010
Bacillus cereus, Bacillus cereus 14579
Manually annotated by BRENDA team
Kepp, O.; Gdoura, A.; Martins, I.; Panaretakis, T.; Schlemmer, F.; Tesniere, A.; Fimia, G.M.; Ciccosanti, F.; Burgevin, A.; Piacentini, M.; Eggleton, P.; Young, P.J.; Zitvogel, L.; van Endert, P.; Kroemer, G.
Lysyl tRNA synthetase is required for the translocation of calreticulin to the cell surface in immunogenic death
Cell Cycle
9
3072-3077
2010
Mus musculus
Manually annotated by BRENDA team
Fang, P.; Zhang, H.M.; Shapiro, R.; Marshall, A.G.; Schimmel, P.; Yang, X.L.; Guo, M.
Structural context for mobilization of a human tRNA synthetase from its cytoplasmic complex
Proc. Natl. Acad. Sci. USA
108
8239-8244
2011
Homo sapiens
Manually annotated by BRENDA team
Khan, S.; Garg, A.; Camacho, N.; Van Rooyen, J.; Kumar Pole, A.; Belrhali, H.; Ribas de Pouplana, L.; Sharma, V.; Sharma, A.
Structural analysis of malaria-parasite lysyl-tRNA synthetase provides a platform for drug development
Acta Crystallogr. Sect. D
69
785-795
2013
Plasmodium falciparum (Q8IDJ8), Plasmodium falciparum
Manually annotated by BRENDA team
Hoepfner, D.; McNamara, C.W.; Lim, C.S.; Studer, C.; Riedl, R.; Aust, T.; McCormack, S.L.; Plouffe, D.M.; Meister, S.; Schuierer, S.; Plikat, U.; Hartmann, N.; Staedtler, F.; Cotesta, S.; Schmitt, E.K.; Petersen, F.; Supek, F.; Glynne, R.J.; Tallarico, J.A.; Porter, J.A.; Fishman, M.C.; Bodenreider, C.; Di, D.i.a.
Selective and specific inhibition of the Plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin
Cell Host Microbe
11
654-663
2012
Plasmodium falciparum, Plasmodium falciparum FCB, Plasmodium falciparum NF54, Plasmodium falciparum Camp R, Plasmodium falciparum FCR3, Plasmodium falciparum D1, Plasmodium falciparum D6
Manually annotated by BRENDA team
Chen, X.; Boonyalai, N.; Lau, C.; Thipayang, S.; Xu, Y.; Wright, M.; Miller, A.D.
Multiple catalytic activities of Escherichia coli lysyl-tRNA synthetase (LysU) are dissected by site-directed mutagenesis
FEBS J.
280
102-114
2013
Escherichia coli
Manually annotated by BRENDA team
Gilreath, M.S.; Roy, H.; Bullwinkle, T.J.; Katz, A.; Navarre, W.W.; Ibba, M.
Beta-lysine discrimination by lysyl-tRNA synthetase
FEBS Lett.
585
3284-3288
2011
Bacillus cereus
Manually annotated by BRENDA team
Dewan, V.; Wei, M.; Kleiman, L.; Musier-Forsyth, K.
Dual role for motif 1 residues of human lysyl-tRNA synthetase in dimerization and packaging into HIV-1
J. Biol. Chem.
287
41955-41962
2012
Homo sapiens
Manually annotated by BRENDA team
Ofir-Birin, Y.; Fang, P.; Bennett, S.P.; Zhang, H.M.; Wang, J.; Rachmin, I.; Shapiro, R.; Song, J.; Dagan, A.; Pozo, J.; Kim, S.; Marshall, A.G.; Schimmel, P.; Yang, X.L.; Nechushtan, H.; Razin, E.; Guo, M.
Structural switch of lysyl-tRNA synthetase between translation and transcription
Mol. Cell
49
30-42
2013
Homo sapiens
Manually annotated by BRENDA team
Motzik, A.; Nechushtan, H.; Foo, S.Y.; Razin, E.
Non-canonical roles of lysyl-tRNA synthetase in health and disease
Trends Mol. Med.
19
726-731
2013
Homo sapiens
Manually annotated by BRENDA team
Kim, B.H.; Jung, W.Y.; Lee, H.; Kang, Y.; Jang, Y.J.; Hong, S.W.; Jeong, H.J.; Yoon, S.O.
Lysyl-tRNA synthetase (KRS) expression in gastric carcinoma and tumor-associated inflammation
Ann. Surg. Oncol.
21
2020-2027
2014
Homo sapiens (Q15046), Homo sapiens
Manually annotated by BRENDA team
Oka, M.; Takegawa, K.; Kimura, Y.
Enzymatic characterization of a class II lysyl-tRNA synthetase, LysS, from Myxococcus xanthus
Arch. Biochem. Biophys.
579
33-39
2015
Myxococcus xanthus (Q1D380), Myxococcus xanthus, Myxococcus xanthus DK 1622 (Q1D380)
Manually annotated by BRENDA team
Oka, M.; Takegawa, K.; Kimura, Y.
Lysyl-tRNA synthetase from Myxococcus xanthus catalyzes the formation of diadenosine penta- and hexaphosphates from adenosine tetraphosphate
Arch. Biochem. Biophys.
604
152-158
2016
Myxococcus xanthus (Q1D380), Myxococcus xanthus, Myxococcus xanthus DK 1622 (Q1D380)
Manually annotated by BRENDA team
Baleva, M.V.; Meyer, M.; Entelis, N.; Tarassov, I.; Kamenski, P.; Masquida, B.
Factors beyond enolase 2 and mitochondrial lysyl-tRNA synthetase precursor are required for tRNA import into yeast mitochondria
Biochemistry (Moscow)
82
1324-1335
2017
Saccharomyces cerevisiae (P32048), Saccharomyces cerevisiae, Saccharomyces cerevisiae YPH499 (P32048)
Manually annotated by BRENDA team
Wang, S.; Prtorius-Ibba, M.; Ataide, S.; Roy, H.; Ibba, M.
Discrimination of cognate and noncognate substrates at the active site of class I lysyl-tRNA synthetase
Biochemistry
45
3646-3652
2006
Pyrococcus horikoshii
Manually annotated by BRENDA team
Young, H.J.; Lee, J.W.; Kim, S.
Function of membranous lysyl-tRNA synthetase and its implication for tumorigenesis
Biochim. Biophys. Acta
1864
1707-1713
2016
Homo sapiens
Manually annotated by BRENDA team
Wright, M.; Azhar, M.A.; Kamal, A.; Miller, A.D.
Syntheses of stable, synthetic diadenosine polyphosphate analogues using recombinant histidine-tagged lysyl tRNA synthetase (LysU)
Bioorg. Med. Chem. Lett.
24
2346-2352
2014
Escherichia coli (P0A8N5), Escherichia coli
Manually annotated by BRENDA team
Cho, H.Y.; Ul Mushtaq, A.; Lee, J.Y.; Kim, D.G.; Seok, M.S.; Jang, M.; Han, B.W.; Kim, S.; Jeon, Y.H.
Characterization of the interaction between lysyl-tRNA synthetase and laminin receptor by NMR
FEBS Lett.
588
2851-2858
2014
Homo sapiens (Q15046)
Manually annotated by BRENDA team
Bonnefond, L.; Castro de Moura, M.; Ribas de Pouplana, L.; Nureki, O.
Crystal structures of Entamoeba histolytica lysyl-tRNA synthetase reveal conformational changes upon lysine binding and a specific helix bundle domain
FEBS Lett.
588
4478-4486
2014
Entamoeba histolytica (C4M7X2), Entamoeba histolytica
Manually annotated by BRENDA team
Remion, A.; Khoder-Agha, F.; Cornu, D.; Argentini, M.; Redeker, V.; Mirande, M.
Identification of protein interfaces within the multi-aminoacyl-tRNA synthetase complex the case of lysyl-tRNA synthetase and the scaffold protein p38
FEBS open bio
6
696-706
2016
Homo sapiens (Q15046), Homo sapiens
Manually annotated by BRENDA team
Zhu, X.G.; Chu, Z.J.; Ying, S.H.; Feng, M.G.
Lysyl-tRNA synthetase (Krs) acts a virulence factor of Beauveria bassiana by its vital role in conidial germination and dimorphic transition
Fungal Biol.
121
956-965
2017
Beauveria bassiana (J5K1T7), Beauveria bassiana, Beauveria bassiana ARSEF 2860 (J5K1T7)
Manually annotated by BRENDA team
McMillan, H.J.; Humphreys, P.; Smith, A.; Schwartzentruber, J.; Chakraborty, P.; Bulman, D.E.; Beaulieu, C.L.; Beaulieu, C.L.; Majewski, J.; Boycott, K.M.; Geraghty, M.T.
Congenital visual impairment and progressive microcephaly due to lysyl-transfer ribonucleic acid (RNA) synthetase (KARS) mutations the expanding phenotype of aminoacyl-transfer RNA synthetase mutations in human disease
J. Child Neurol.
30
1037-1043
2015
Homo sapiens (Q15046), Homo sapiens
Manually annotated by BRENDA team
Lee, M.S.; Kwon, H.; Nguyen, L.T.; Lee, E.Y.; Lee, C.Y.; Choi, S.H.; Kim, M.H.
Shiga toxins trigger the secretion of lysyl-tRNA synthetase to enhance proinflammatory responses
J. Microbiol. Biotechnol.
26
432-439
2016
Homo sapiens, Streptococcus pneumoniae (Q04LI2), Streptococcus pneumoniae D39 / NCTC 7466 (Q04LI2)
Manually annotated by BRENDA team
Khan, S.; Sharma, A.; Belrhali, H.; Yogavel, M.; Sharma, A.
Structural basis of malaria parasite lysyl-tRNA synthetase inhibition by cladosporin
J. Struct. Funct. Genomics
15
63-71
2014
Plasmodium falciparum (Q8IDJ8), Plasmodium falciparum
Manually annotated by BRENDA team
Singh, I.; Yadav, A.R.; Mohanty, K.K.; Katoch, K.; Sharma, P.; Mishra, B.; Bisht, D.; Gupta, U.D.; Sengupta, U.
Molecular mimicry between Mycobacterium leprae proteins (50S ribosomal protein L2 and lysyl-tRNA synthetase) and myelin basic protein a possible mechanism of nerve damage in leprosy
Microbes Infect.
17
247-257
2015
Mycobacterium leprae
Manually annotated by BRENDA team
Nam, S.H.; Kim, D.; Lee, M.S.; Lee, D.; Kwak, T.K.; Kang, M.; Ryu, J.; Kim, H.J.; Song, H.E.; Choi, J.; Lee, G.H.; Kim, S.Y.; Park, S.H.; Kim, D.G.; Kwon, N.H.; Kim, T.Y.; Thiery, J.P.; Kim, S.; Lee, J.W.
Noncanonical roles of membranous lysyl-tRNA synthetase in transducing cell-substrate signaling for invasive dissemination of colon cancer spheroids in 3D collagen I gels
Oncotarget
6
21655-21674
2015
Homo sapiens (Q15046)
Manually annotated by BRENDA team
Boulos, S.; Park, M.C.; Zeibak, M.; Foo, S.Y.; Jeon, Y.K.; Kim, Y.T.; Motzik, A.; Tshori, S.; Hamburger, T.; Kim, S.; Nechushtan, H.; Razin, E.
Serine 207 phosphorylated lysyl-tRNA synthetase predicts disease-free survival of non-small-cell lung carcinoma
Oncotarget
8
65186-65198
2017
Homo sapiens (Q15046), Homo sapiens
Manually annotated by BRENDA team
Ravishankar, S.; Ambady, A.; Swetha, R.G.; Anbarasu, A.; Ramaiah, S.; Sambandamurthy, V.K.
Essentiality assessment of cysteinyl and lysyl-tRNA synthetases of Mycobacterium smegmatis
PLoS ONE
11
e0147188
2016
Mycolicibacterium smegmatis (A0QYV1), Mycolicibacterium smegmatis (A0R577), Mycolicibacterium smegmatis, Mycolicibacterium smegmatis mc2155 / ATCC 700084 (A0QYV1), Mycolicibacterium smegmatis mc2155 / ATCC 700084 (A0R577)
Manually annotated by BRENDA team