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ATP + L-lysine + tRNALys
AMP + diphosphate + L-lysyl-tRNALys
ATP + L-lysine + tRNALys
AMP + L-lysyl-tRNALys + diphosphate
ATP + lysine + tRNALys
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primary role is the translation of genetic information into protein structure
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ATP + lysine + tRNALys
AMP + L-lysyl-tRNALys + diphosphate
additional information
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ATP + L-lysine + tRNALys
AMP + diphosphate + L-lysyl-tRNALys
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ATP + L-lysine + tRNALys
AMP + diphosphate + L-lysyl-tRNALys
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the reaction catalyzed by the enzyme plays an important role in the transport of aminoacylated tRNAs from the nucleus to the cytoplasm
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ATP + L-lysine + tRNALys
AMP + diphosphate + L-lysyl-tRNALys
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ATP + L-lysine + tRNALys
AMP + diphosphate + L-lysyl-tRNALys
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ATP + L-lysine + tRNALys
AMP + diphosphate + L-lysyl-tRNALys
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ATP + L-lysine + tRNALys
AMP + diphosphate + L-lysyl-tRNALys
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ATP + L-lysine + tRNALys
AMP + diphosphate + L-lysyl-tRNALys
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ATP + L-lysine + tRNALys
AMP + diphosphate + L-lysyl-tRNALys
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ATP + L-lysine + tRNALys
AMP + diphosphate + L-lysyl-tRNALys
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ATP + L-lysine + tRNALys
AMP + diphosphate + L-lysyl-tRNALys
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ATP + L-lysine + tRNALys
AMP + diphosphate + L-lysyl-tRNALys
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ATP + L-lysine + tRNALys
AMP + diphosphate + L-lysyl-tRNALys
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ATP + L-lysine + tRNALys
AMP + diphosphate + L-lysyl-tRNALys
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the reaction catalyzed by the enzyme plays an important role in the transport of aminoacylated tRNAs from the nucleus to the cytoplasm
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?
ATP + L-lysine + tRNALys
AMP + diphosphate + L-lysyl-tRNALys
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ATP + L-lysine + tRNALys
AMP + diphosphate + L-lysyl-tRNALys
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ATP + L-lysine + tRNALys
AMP + diphosphate + L-lysyl-tRNALys
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ATP + L-lysine + tRNALys
AMP + diphosphate + L-lysyl-tRNALys
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ATP + L-lysine + tRNALys
AMP + diphosphate + L-lysyl-tRNALys
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ATP + L-lysine + tRNALys
AMP + diphosphate + L-lysyl-tRNALys
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ATP + L-lysine + tRNALys
AMP + diphosphate + L-lysyl-tRNALys
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ATP + L-lysine + tRNALys
AMP + diphosphate + L-lysyl-tRNALys
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ATP + L-lysine + tRNALys
AMP + diphosphate + L-lysyl-tRNALys
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ATP + L-lysine + tRNALys
AMP + diphosphate + L-lysyl-tRNALys
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ATP + L-lysine + tRNALys
AMP + diphosphate + L-lysyl-tRNALys
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ATP + L-lysine + tRNALys
AMP + diphosphate + L-lysyl-tRNALys
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ATP + L-lysine + tRNALys
AMP + L-lysyl-tRNALys + diphosphate
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r
ATP + L-lysine + tRNALys
AMP + L-lysyl-tRNALys + diphosphate
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ATP + L-lysine + tRNALys
AMP + L-lysyl-tRNALys + diphosphate
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ATP + L-lysine + tRNALys
AMP + L-lysyl-tRNALys + diphosphate
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ATP + L-lysine + tRNALys
AMP + L-lysyl-tRNALys + diphosphate
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ATP + L-lysine + tRNALys
AMP + L-lysyl-tRNALys + diphosphate
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ATP + L-lysine + tRNALys
AMP + L-lysyl-tRNALys + diphosphate
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ATP + L-lysine + tRNALys
AMP + L-lysyl-tRNALys + diphosphate
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ATP + L-lysine + tRNALys
AMP + L-lysyl-tRNALys + diphosphate
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ATP + L-lysine + tRNALys
AMP + L-lysyl-tRNALys + diphosphate
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ATP + L-lysine + tRNALys
AMP + L-lysyl-tRNALys + diphosphate
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ATP + L-lysine + tRNALys
AMP + L-lysyl-tRNALys + diphosphate
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during early assembly of human immunodeficiency virus type 1, an assembly complex is formed, the components of which include genomic RNA, Gag, Gag-Pol, tRNALys, and lysyl tRNA synthetase. Directly increasing or decreasing cellular expression of LysRS results in corresponding changes in viral infectivity and in the viral concentrations of LysRS, tRNALys, and reverse transcriptase. Overexpression of LysRS in the cell reduces viral protease activity
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ATP + L-lysine + tRNALys
AMP + L-lysyl-tRNALys + diphosphate
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enzyme facilitates the selective packaging of tRNA3 Lys. Newly synthesized LysRS is associated with Gag protein after a 10 minute pulse with [35 S]cysteine/methionine. Incorporation of LysRS into HIV-1 is very sensitive to the inhibition of new synthesis of LysRS
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ATP + L-lysine + tRNALys
AMP + L-lysyl-tRNALys + diphosphate
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the enzyme is secreted to trigger proinflammatory response. TNF-alpha induces secretion of lysyl-tRNA synthetase. The secreted enzyme binds to macrophages and peripheral blood mononuclear cell to enhance the TNF-alpha production and their migration. The mitogen-activated protein kinases, extracellular signal-regulated kinase, p38 mitogen-activated protein kinase and inhibitory protein Galphai are involved in the signal transduction triggered by lysyl-tRNA synthetase. Lysyl-tRNA synthetase may work as a signaling molecule, inducing immune response through the activation of monocyte/macrophages
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ATP + L-lysine + tRNALys
AMP + L-lysyl-tRNALys + diphosphate
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ATP + L-lysine + tRNALys
AMP + L-lysyl-tRNALys + diphosphate
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ATP + L-lysine + tRNALys
AMP + L-lysyl-tRNALys + diphosphate
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ATP + lysine + tRNALys
AMP + L-lysyl-tRNALys + diphosphate
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ATP + lysine + tRNALys
AMP + L-lysyl-tRNALys + diphosphate
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the enzymes major function is to provide Lys-tRNALys fpr protein biosynthesis
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r
ATP + lysine + tRNALys
AMP + L-lysyl-tRNALys + diphosphate
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ATP + lysine + tRNALys
AMP + L-lysyl-tRNALys + diphosphate
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r
ATP + lysine + tRNALys
AMP + L-lysyl-tRNALys + diphosphate
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ATP + lysine + tRNALys
AMP + L-lysyl-tRNALys + diphosphate
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additional information
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phylogenetic comparison
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additional information
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aminoacyl-tRNA is channeled in vivo by probably direct transfer to elongation factor I
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additional information
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phylogenetic comparison
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additional information
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enzyme is selectively packaged into virions during assembly of the human immunodeficiency virus type 1, i.e. HIV-1, through interaction with the viral Pr55gag protein, overview
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additional information
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the enzyme signals and mediates the selective recognition and packaging of tRNALys isoacceptors into HIV particles, the human enzyme is selectively packaged into virions of the human immunodeficiency virus during virus assembly, along with and independent of its cognate tRNALys isoacceptors, packaging is mediated by the viral protein Gag, which alone is sufficient for the incorporation, determination of interaction regions
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additional information
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phylogenetic comparison
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additional information
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lysyl-tRNA synthetase from Myxococcus xanthus catalyzes the formation of diadenosine penta- and hexaphosphates from adenosine tetraphosphate
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additional information
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lysyl-tRNA synthetase from Myxococcus xanthus catalyzes the formation of diadenosine penta- and hexaphosphates from adenosine tetraphosphate
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additional information
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lysyl-tRNA synthetase from Myxococcus xanthus catalyzes the formation of diadenosine penta- and hexaphosphates from adenosine tetraphosphate
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additional information
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aminoacyl-tRNA is channeled in vivo by probably direct transfer to elongation factor I
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additional information
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pneumococcal LysRS mischarges both tRNALys isoacceptors with multiple amino acids requiring a posttransfer editing mechanism
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additional information
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pneumococcal LysRS mischarges both tRNALys isoacceptors with multiple amino acids requiring a posttransfer editing mechanism
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