Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell surface | the enzyme is exposed on the surface of stressed cells, on which it co-localized with calreticulin in lipid rafts | Mus musculus | 9986 | - |
endoplasmic reticulum | - |
Mus musculus | 5783 | - |
extracellular | KARS also occurs in the supernatant of stressed cells | Mus musculus | - |
- |
additional information | anthracyclin-induced translocation of KARS from the endoplasmic reticulum to the cell surface | Mus musculus | - |
- |
plasma membrane | the enzyme is exposed on the surface of stressed cells, on which it co-localized with calreticulin in lipid rafts | Mus musculus | 5886 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
CT-26 cell | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
KARS | - |
Mus musculus |
lysyl tRNA synthetase | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | enzyme depletion by KARS specific siRNA | down |
General Information | Comment | Organism |
---|---|---|
malfunction | depletion of KARS with small interfering RNAs suppresses calreticulin exposure on the cell surface induced by anthracyclines or UVC light | Mus musculus |
additional information | recombinant KARS protein is unable to influence the binding of recombinant CRT to the cell surface. Moreover, recombinant KARS protein is unable to stimulate macrophages in vitro | Mus musculus |
physiological function | KARS mediates translocation of calreticulin from endoplasmic reticulum to the plasma membrane at the cell surface | Mus musculus |