5.4.99.64: 2-hydroxyisobutanoyl-CoA mutase
This is an abbreviated version!
For detailed information about 2-hydroxyisobutanoyl-CoA mutase, go to the full flat file.
Word Map on EC 5.4.99.64
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5.4.99.64
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b12-dependent
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aquincola
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tertiaricarbonis
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acyl-coa
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s-3-hydroxybutyryl-coa
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2-hydroxyisobutyric
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chaperone
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mutases
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2-hydroxyisobutyrylation
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isomerization
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isovaleryl-coa
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tert-butyl
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thioester
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synthesis
- 5.4.99.64
-
b12-dependent
-
aquincola
- tertiaricarbonis
- acyl-coa
-
s-3-hydroxybutyryl-coa
-
2-hydroxyisobutyric
- chaperone
- mutases
-
2-hydroxyisobutyrylation
-
isomerization
- isovaleryl-coa
-
tert-butyl
- thioester
- synthesis
Reaction
Synonyms
2-hydroxyisobutyryl-CoA mutase, Btus_0469, Btus_0470, EC 5.3.3.20, HCM, HcmA, hcmAB, HcmB, RcmA, RcmB
ECTree
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Crystallization
Crystallization on EC 5.4.99.64 - 2-hydroxyisobutanoyl-CoA mutase
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crystal structure in complex with coenzyme B12 and the substrates (S)-3-hydroxybutyryl- and 2-hydroxyisobutyryl-CoA in alternative binding. subunit HcmA residues IleA90 and AspA117. AspA117 determine the orientation of the hydroxyl group of the acyl-CoA esters by H-bond formation, thus determining stereospecificity of catalysis
crystal structure of the enzyme in complex with coenzyme B12 and the substrates (S)-3-hydroxybutyryl- and 2-hydroxyisobutyryl-CoA in alternative binding. Crystals are grown in 16% PEG 3350, 0.1 M Tris,pH 7.5, by the hanging-drop vapor diffusion method at 4°C