5.4.99.1: methylaspartate mutase
This is an abbreviated version!
For detailed information about methylaspartate mutase, go to the full flat file.
Word Map on EC 5.4.99.1
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5.4.99.1
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adenosylcobalamin
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adenosylcobalamin-dependent
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homolysis
-
b12-dependent
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cobiialamin
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tetanomorphum
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cobalt-carbon
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cochlearium
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s-glutamate
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b12-binding
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2s,3s-3-methylaspartate
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5'-deoxyadenosine
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corrin
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adenosyl
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cobalamin-binding
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cobalamin-dependent
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methylmalonyl
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isomerizations
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mutases
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5\'-deoxyadenosyl
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2-methyleneglutarate
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mesaconate
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dimethylbenzimidazole
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synthesis
- 5.4.99.1
- adenosylcobalamin
-
adenosylcobalamin-dependent
-
homolysis
-
b12-dependent
-
cobiialamin
- tetanomorphum
-
cobalt-carbon
- cochlearium
-
s-glutamate
-
b12-binding
-
2s,3s-3-methylaspartate
- 5'-deoxyadenosine
-
corrin
-
adenosyl
-
cobalamin-binding
-
cobalamin-dependent
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methylmalonyl
-
isomerizations
- mutases
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5\'-deoxyadenosyl
- 2-methyleneglutarate
- mesaconate
- dimethylbenzimidazole
- synthesis
Reaction
Synonyms
AdoCbl-dependent glutamate mutase, Glm, GlmS, Glutamate isomerase, Glutamate mutase, Glutamic acid isomerase, Glutamic acid mutase, Glutamic isomerase, Glutamic mutase, Methylaspartic acid mutase, Mutase, methylaspartate, mutE, mutS, SanU, SanV
ECTree
5.4.99.1 methylaspartate mutaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 5.4.99.1 - methylaspartate mutase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(S)-2-hydroxyglutarate
(2S,3S)-3-methylmalate
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-
analysis of the energy profile for the various intermediate steps of reaction
-
?
L-2-hydroxyglutarate
L-threo-3-methylmalate
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rate-limiting step is most likely the rearrangement of the 2-hydroxyglutaryl radical to the 3-methylmalyl radical
-
?
additional information
?
-
-
the catalytic mechanism proceeds via a fragmentation/recombination sequence with intermediates stabilized by partial protonation/deprotonation
-
?
Glu
?
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the enzyme is involved in the dissimilation of Glu to acetyl-CoA and pyruvate through the following pathway
-
-
?
Glu
?
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the enzyme is involved in the dissimilation of Glu to acetyl-CoA and pyruvate through the following pathway
-
-
?
L-Glu
threo-3-Methylaspartate
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equilibrium favours glutamate formation
-
?
L-Glu
threo-3-Methylaspartate
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high-level quantum chemistry calculations on catalytic reaction. Overall reaction is exothermic by 5.2 kJ per mol, while the equilibrium for the reaction in aqueous solution lies in the opposite direction
-
-
?
L-Glu
threo-3-Methylaspartate
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equilibrium favours glutamate formation
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?
L-Glu
threo-3-Methylaspartate
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in the reverse reaction: erythro-3-methylaspartate does not serve as substrate
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?
L-Glu
threo-3-Methylaspartate
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equilibrium favours glutamate formation
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?
L-glutamate
L-threo-3-methylaspartate
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kinetic competence of acrylate and glycyl radical as intermediates in the rearrangement of glutamate to methylaspartate
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?
L-threo-3-methylaspartate
L-glutamate
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-
-
-
?
L-threo-3-methylaspartate
L-glutamate
-
-
-
r
L-threo-3-methylaspartate
L-glutamate
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equilibrium constants favouring glutamate over 3-methylaspartate, formation of L-threo-(2S,3S)- and L-erythro-(2S,3R)-3-methylaspartate in the reverse reaction direction
no activity with D-glutamate
-
?
L-threo-3-methylaspartate
L-glutamate
Fusobacterium varium NCTC 10560 / ATCC 8501
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equilibrium constants favouring glutamate over 3-methylaspartate, formation of L-threo-(2S,3S)- and L-erythro-(2S,3R)-3-methylaspartate in the reverse reaction direction
no activity with D-glutamate
-
?
