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5.4.99.1: methylaspartate mutase

This is an abbreviated version!
For detailed information about methylaspartate mutase, go to the full flat file.

Word Map on EC 5.4.99.1

Reaction

L-threo-3-methylaspartate
=
L-glutamate

Synonyms

AdoCbl-dependent glutamate mutase, Glm, GlmS, Glutamate isomerase, Glutamate mutase, Glutamic acid isomerase, Glutamic acid mutase, Glutamic isomerase, Glutamic mutase, Methylaspartic acid mutase, Mutase, methylaspartate, mutE, mutS, SanU, SanV

ECTree

     5 Isomerases
         5.4 Intramolecular transferases
             5.4.99 Transferring other groups
                5.4.99.1 methylaspartate mutase

Inhibitors

Inhibitors on EC 5.4.99.1 - methylaspartate mutase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2S)-Homocysteic acid
-
-
(2S,3R)-3-Fluoroglutamate
-
-
(2S,3R)-3-Methylglutamate
-
-
(2S,3S)-3-Methylglutamate
-
-
(2S,4S)-4-Fluoroglutamate
-
-
(2S,4S)-4-Fluoroglutamic acid
(S)-2-thiolglutaric acid
-
high-level quantum chemical calculations of reaction intermediates
(S)-3-Methylitaconate
-
-
(S)-3-Methylitaconic acid
-
-
1-Bromo-cyclopropane-cis-1,2-diacidic acid
-
-
1-Bromo-cyclopropane-trans-1,2-diacidic acid
-
-
2-Bromo-2,3-Methanosuccinic acid
-
-
2-ketoglutaric acid
-
high-level quantum chemical calculations of reaction intermediates
2-Methyleneglutarate
-
binding of the 2-methyleneglutarate to glutamate mutase initiates homolysis of adensosylcobalamin, irreversible inhibition
2-Methyleneglutaric acid
2-oxoglutarate
-
inactivates, formation of the C-4 radical of 2-oxoglutarate is a facile process, but it does not undergo further reactions
2-thiolglutarate
-
competitive. 2-Thiolglutarate elicits cobalt-carbon bond homolysis and the formation of 5’-deoxyadenosine. 2-Thiolglutarate first forms a thiolglutaryl radical at C-4 that then undergoes fragmentation to produce acrylate and the sulfur-stabilized thioglycolyl radical which accumulates on the enzyme
Hog intrinsic factor
-
iodoacetate
Itaconic acid
additional information
-
charcoal adsorbs coenzyme B12 and inactivates glutamate mutase
-