5.4.99.1: methylaspartate mutase
This is an abbreviated version!
For detailed information about methylaspartate mutase, go to the full flat file.
Word Map on EC 5.4.99.1
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5.4.99.1
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adenosylcobalamin
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adenosylcobalamin-dependent
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homolysis
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b12-dependent
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cobiialamin
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tetanomorphum
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cobalt-carbon
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cochlearium
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s-glutamate
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b12-binding
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2s,3s-3-methylaspartate
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5'-deoxyadenosine
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corrin
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adenosyl
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cobalamin-binding
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cobalamin-dependent
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methylmalonyl
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isomerizations
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mutases
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5\'-deoxyadenosyl
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2-methyleneglutarate
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mesaconate
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dimethylbenzimidazole
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synthesis
- 5.4.99.1
- adenosylcobalamin
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adenosylcobalamin-dependent
-
homolysis
-
b12-dependent
-
cobiialamin
- tetanomorphum
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cobalt-carbon
- cochlearium
-
s-glutamate
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b12-binding
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2s,3s-3-methylaspartate
- 5'-deoxyadenosine
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corrin
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adenosyl
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cobalamin-binding
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cobalamin-dependent
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methylmalonyl
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isomerizations
- mutases
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5\'-deoxyadenosyl
- 2-methyleneglutarate
- mesaconate
- dimethylbenzimidazole
- synthesis
Reaction
Synonyms
AdoCbl-dependent glutamate mutase, Glm, GlmS, Glutamate isomerase, Glutamate mutase, Glutamic acid isomerase, Glutamic acid mutase, Glutamic isomerase, Glutamic mutase, Methylaspartic acid mutase, Mutase, methylaspartate, mutE, mutS, SanU, SanV
ECTree
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Inhibitors
Inhibitors on EC 5.4.99.1 - methylaspartate mutase
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(S)-2-thiolglutaric acid
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high-level quantum chemical calculations of reaction intermediates
2-ketoglutaric acid
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high-level quantum chemical calculations of reaction intermediates
2-Methyleneglutarate
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binding of the 2-methyleneglutarate to glutamate mutase initiates homolysis of adensosylcobalamin, irreversible inhibition
2-oxoglutarate
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inactivates, formation of the C-4 radical of 2-oxoglutarate is a facile process, but it does not undergo further reactions
2-thiolglutarate
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competitive. 2-Thiolglutarate elicits cobalt-carbon bond homolysis and the formation of 5-deoxyadenosine. 2-Thiolglutarate first forms a thiolglutaryl radical at C-4 that then undergoes fragmentation to produce acrylate and the sulfur-stabilized thioglycolyl radical which accumulates on the enzyme
additional information
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charcoal adsorbs coenzyme B12 and inactivates glutamate mutase
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iodoacetate
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specifically alkylates Cys15 in enzyme component S with concomitant irreversible loss of enzyme activity