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Literature summary for 5.4.99.1 extracted from

  • Yoon, M.; Patwardhan, A.; Qiao, C.; Mansoorabadi, S.O.; Menefee, A.L.; Reed, G.H.; Marsh, E.N.
    Reaction of adenosylcobalamin-dependent glutamate mutase with 2-thiolglutarate (2006), Biochemistry, 45, 11650-11657.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
2-thiolglutarate competitive. 2-Thiolglutarate elicits cobalt-carbon bond homolysis and the formation of 5’-deoxyadenosine. 2-Thiolglutarate first forms a thiolglutaryl radical at C-4 that then undergoes fragmentation to produce acrylate and the sulfur-stabilized thioglycolyl radical which accumulates on the enzyme Clostridium cochlearium

Organism

Organism UniProt Comment Textmining
Clostridium cochlearium
-
-
-

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.05
-
2-thiolglutarate pH 7.0 Clostridium cochlearium