5.3.3.1: steroid DELTA-isomerase

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For detailed information about steroid DELTA-isomerase, go to the full flat file.

Word Map on EC 5.3.3.1

5.3.3.1

steroidogenic

progesterone

adrenal

steroidogenesis

androgen

p450scc

leydig

star

testicular

pregnenolone

17beta-hsd

lh

aromatase

5-3-ketosteroids

gonad

testosteroni

granulosa

dehydroepiandrosterone

luteal

androstenedione

17beta-hydroxysteroid

dheas

theca

p450arom

17alpha-hydroxylase

neurosteroids

cyp11a1

trilostane

19-nortestosterone

dienolate

5alpha-reductase

equilenin

low-barrier

17alpha-hydroxylase/17,20-lyase

interna

3betahsd

delta5-3beta-hydroxysteroid

intracrine

double-bond

hsd3b1

talalay

20alpha-hsd

beta-proton

Reaction

Synonyms

3-Keto-DELTA5-steroid isomerase, 3-Ketosteroid DELTA5-->DELTA4-isomerase, 3-ketosteroid isomerase, 3-Oxo steroid DELTA4-DELTA5-isomerase, 3-Oxo-delta5 steroid isomerase, 3-oxo-DELTA5-steroid isomerase, 3-Oxosteroid DELTA4-DELTA5-isomerase, 3-Oxosteroid DELTA5-DELTA4-isomerase, 3-Oxosteroid isomerase, 3beta-HSD, 3beta-HSD/isomerase, 3beta-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase, 3beta-hydroxysteroid dehydrogenase/DELTA5-DELTA4 isomerase, 3beta-hydroxysteroid dehydrogenase/isomerase, 3beta-hydroxysteroid dehydrogenase/isomerase type 1, 3beta-hydroxysteroid dehydrogenase/isomerase type 2, 3KSI, 5-Ene-4-ene isomerase, 5-Pregnene-3,20-dione isomerase, delta 5-3-ketosteroid isomerase, DELTA-3-ketosteroid isomerase, Delta-5-3-ketosteroid isomerase, DELTA5(or DELTA4)-3-keto steroid isomerase, DELTA5-3-keto steroid isomerase, DELTA5-3-ketosteroid isomerase, DELTA5-3-oxosteroid isomerase, DELTA5-ketosteroid isomerase, DELTA5-steroid isomerase, glutathione transferase A3-3, GST A3-3, Hydroxysteroid isomerase, Isomerase, steroid DELTA, ketosteroid isomerase, KSI, More, Steroid 5-->4-isomerase, Steroid isomerase, TI, TI-WT, type I 3beta-hydroxysteroid dehydrogenase/isomerase

ECTree

5 Isomerases

5.3 Intramolecular oxidoreductases

5.3.3 Transposing C=C bonds

5.3.3.1 steroid DELTA-isomerase

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Results	in table
1	Activating Compound
410	AA Sequence
1	CAS Registry Number
17	Cloned(Commentary)
7	Cofactor
25	Crystallization (Commentary)
270	Disease/ Diagnostics
1	Expression
1	General Information
5	General Stability
5	IC50 Value
72	Inhibitors
7	kcat/KM [mM/s]
22	Ki Value [mM]
99	KM Value [mM]
10	Localization
25	Molecular Weight [Da]
16	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
98	Organism
16	Pathway
196	PDB ID
8	pH Optimum
3	pH Range
90	Protein Variants
25	Purification (Commentary)
7	Reaction
4	Reaction Type
97	Reference
8	Renatured (Commentary)
41	Source Tissue
6	Specific Activity [micromol/min/mg]
4	Storage Stability
91	Substrates and Products (Substrate)
15	Subunits
112	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
1	Temperature Range [°C]
3	Temperature Stability [°C]
86	Turnover Number [1/s]

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Source Tissue on EC 5.3.3.1 - steroid DELTA-isomerase

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type 1 isozyme

of embryo. Levels of bifunctional 3beta-hydroxysteroid-dehydrogenase/DELTA4-DELTA5-isomerase are sexually dimorphic and developmental age-dependent. MRNA levels are higher in females than in males at E7, whereas this dimorphism is reversed at E9 and E15. In females, the highest mRNA level is at E7, whereas in males the levels are significantly higher at E9 and E17 than at E7 and E11. Sexual dimorphism can only be detcted in prosencephalon, can not be observed before gonadal sexual differentiation, and is not paralleled by a dimorphism in brain content of progesterone

type 1 isozyme