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0.0223
17beta-Hydroxy-5(10)-estren-3-one
-
-
0.0328 - 0.256
5(10)-estrene-3,17-dione
0.048
5,10-Seco-19-norpregn-5-yne-3,10,20-trione
-
-
0.413
5,10-secoestr-5-yne-3,10,20,trione
-
-
0.0001 - 0.548
5-androstene-3,17-dione
0.007
5-Cholesten-3-one
Nocardia erythropolis
-
-
0.0093 - 0.068
5-Pregnene-3,20-dione
0.023 - 0.0735
androstene-3,17-dione
0.0175 - 0.0884
dehydroepiandrosterone
0.01
DELTA5-pregnen-3,20-dione
-
25°C, pH 7.5
additional information
additional information
-
0.0328
5(10)-estrene-3,17-dione
-
25°C, pH 7.0, mutant enzyme F82A
0.0651
5(10)-estrene-3,17-dione
-
25°C, pH 7.0, mutant enzyme F82L
0.0982
5(10)-estrene-3,17-dione
-
25°C, pH 7.0, mutant enzyme F54L
0.11
5(10)-estrene-3,17-dione
-
25°C, pH 7.0, wild-type enzyme
0.256
5(10)-estrene-3,17-dione
-
25°C, pH 7.0, mutant enzyme F54A
0.0001
5-androstene-3,17-dione
-
wild-type, 27°C, pH 7.4
0.00041
5-androstene-3,17-dione
-
mutant S124T, 27°C, pH 7.4
0.00083
5-androstene-3,17-dione
-
mutant M187T, 27°C, pH 7.4
0.0024
5-androstene-3,17-dione
-
27°C, pH 7.4, wild-type enzyme
0.0033
5-androstene-3,17-dione
-
27°C, pH 7.4, mutant enzyme D241N
0.0044
5-androstene-3,17-dione
-
27°C, pH 7.4, mutant enzyme D265N
0.0149
5-androstene-3,17-dione
-
25°C, pH 7.0, mutant enzyme F82A
0.0171
5-androstene-3,17-dione
mutant enzyme Y14F, at pH 7.0, temperature not specified in the publication
0.023
5-androstene-3,17-dione
mutant enzyme Y55F, at pH 7.0, temperature not specified in the publication
0.0237
5-androstene-3,17-dione
-
-
0.024
5-androstene-3,17-dione
-
-
0.0252
5-androstene-3,17-dione
-
22°C, pH 7.4, truncated cytosolic enzyme DEALTA283-310
0.0269
5-androstene-3,17-dione
-
pH 7.0, 25°C, mutant enzyme Y14F
0.0276
5-androstene-3,17-dione
-
-
0.0279
5-androstene-3,17-dione
-
22°C, pH 7.4, wild-type enzyme
0.0287
5-androstene-3,17-dione
-
25°C, pH 7.0, mutant enzyme Y14F/Y55F
0.033
5-androstene-3,17-dione
mutant D38E, pH 7.0, 5.4 °C
0.036
5-androstene-3,17-dione
-
-
0.037
5-androstene-3,17-dione
mutant D38E, pH 7.0, 10.3 °C
0.04
5-androstene-3,17-dione
mutant D38E, pH 7.0, 15.3 °C
0.04
5-androstene-3,17-dione
mutant D38E, pH 7.0, 20.1 °C
0.0417
5-androstene-3,17-dione
mutant enzyme Y115F, at pH 7.0, temperature not specified in the publication
0.0475
5-androstene-3,17-dione
-
pH 7.0, 25°C, mutant enzyme Y14F/D99N
0.0481
5-androstene-3,17-dione
-
pH 7.0, 25°C, mutant enzyme Y14F/D99E
0.0486
5-androstene-3,17-dione
25°C, pH 7.0, mutant enzyme F116W
0.0499
5-androstene-3,17-dione
-
pH 7.0, 25°C, wild-type enzyme
0.0499
5-androstene-3,17-dione
-
25°C, pH 7.0, wild-type enzyme
0.0499
5-androstene-3,17-dione
-
wild-type, 25°C, pH 7.0
0.0499
5-androstene-3,17-dione
wild type enzyme, at pH 7.0, temperature not specified in the publication
0.0502
5-androstene-3,17-dione
mutant enzyme Y30F/Y55F, at pH 7.0, temperature not specified in the publication
0.0503
5-androstene-3,17-dione
-
pH 7.0, 25°C, wild-type enzyme
0.0503
5-androstene-3,17-dione
-
25°C, pH 7.0, wild-type enzyme
0.0513
5-androstene-3,17-dione
-
25°C, pH 7.0, mutant enzyme Y14F/Y30F/Y55F
0.0539
5-androstene-3,17-dione
-
25°C, pH 7.0, mutant enzyme F82L
0.055
5-androstene-3,17-dione
mutant D38E, pH 7.0, 25.0 °C
0.0552
5-androstene-3,17-dione
mutant enzyme Y30F, at pH 7.0, temperature not specified in the publication
0.0578
5-androstene-3,17-dione
-
25°C, pH 7.0, mutant enzyme Y14F/Y30F/Y55F/D99N
0.0579
5-androstene-3,17-dione
-
25°C, pH 7.0, mutant enzyme F54A
0.0616
5-androstene-3,17-dione
-
pH 7.0, 25°C, mutant enzyme D99E
0.063
5-androstene-3,17-dione
mutant D38E, pH 7.0, 29.9 °C
0.067
5-androstene-3,17-dione
-
25°C, pH 6.5, solvent D2O, mutant enzyme D38A
0.073
5-androstene-3,17-dione
-
25°C, pH 8.5, solvent D2O, mutant enzyme D38A
0.077
5-androstene-3,17-dione
-
25°C, pH 7.0, mutant enzyme F54L
0.0773
5-androstene-3,17-dione
mutant enzyme Y30F/Y55F/Y115F, at pH 7.0, temperature not specified in the publication
0.0787
5-androstene-3,17-dione
-
25°C, pH 7.0, mutant enzyme Y14F/Y30F
0.0795
5-androstene-3,17-dione
-
mutant L125F/V127F, 25°C, pH 7.0
0.085
5-androstene-3,17-dione
-
25°C, pH 7.5, solvent D2O, mutant enzyme D38A
0.088
5-androstene-3,17-dione
-
27°C, pH 7.4
0.0918
5-androstene-3,17-dione
-
25°C, pH 7.0, mutant enzyme Y14F/Y30F/Y55F/D99L
0.094
5-androstene-3,17-dione
-
25°C, pH 8.5, solvent H2O, mutant enzyme D38A
0.096
5-androstene-3,17-dione
-
25°C, pH 7.5, solvent H2O, mutant enzyme D38A
0.0982
5-androstene-3,17-dione
-
pH 7.0, 25°C, mutant enzyme Y14F/D99L
0.099
5-androstene-3,17-dione
-
25°C, pH 6.5, solvent H2O, mutant enzyme D38A
0.0995
5-androstene-3,17-dione
-
mutant W92A, 25°C, pH 7.0
0.1185
5-androstene-3,17-dione
-
mutant W92A/L125A/V127A, 25°C, pH 7.0
0.1375
5-androstene-3,17-dione
-
mutant L125A/V127A, 25°C, pH 7.0
0.149
5-androstene-3,17-dione
-
25°C, pH 7.0, mutant enzyme W116F
0.1528
5-androstene-3,17-dione
25°C, pH 7.0, wild-type enzyme
0.173
5-androstene-3,17-dione
-
pH 7.0, 25°C, mutant enzyme E118A
0.174
5-androstene-3,17-dione
-
25°C, pH 7.0, mutant enzyme W116A
0.258
5-androstene-3,17-dione
-
pH 7.0, 25°C, mutant enzyme D99L
0.258
5-androstene-3,17-dione
-
pH 7.0, 25°C, mutant enzyme N120A
0.261
5-androstene-3,17-dione
-
pH 7.0, 25°C, mutant enzyme E118A/N120A
0.31 - 0.33
5-androstene-3,17-dione
-
-
0.38
5-androstene-3,17-dione
-
-
0.548
5-androstene-3,17-dione
Nocardia erythropolis
-
-
0.0093
5-Pregnene-3,20-dione
-
-
0.0097
5-Pregnene-3,20-dione
-
-
0.011
5-Pregnene-3,20-dione
-
-
0.0125
5-Pregnene-3,20-dione
Nocardia erythropolis
-
-
0.068
5-Pregnene-3,20-dione
-
-
0.023
androstene-3,17-dione
-
25°C, pH 7.0, mutant enzyme Y55F
0.0258
androstene-3,17-dione
-
25°C, pH 7.0, mutant enzyme D99L
0.0502
androstene-3,17-dione
-
25°C, pH 7.0, mutant enzyme Y30F/Y55F
0.0552
androstene-3,17-dione
-
25°C, pH 7.0, mutant enzyme Y30F
0.0619
androstene-3,17-dione
-
25°C, pH 7.0, mutant enzyme Y55F/D99L
0.0735
androstene-3,17-dione
-
25°C, pH 7.0, mutant enzyme Y30F/D99L
0.0175
dehydroepiandrosterone
-
mutant R240Q, isoform 2, 27°C, pH 7.4
0.0279
dehydroepiandrosterone
-
wild-type, isoform 1, 27°C, pH 7.4
0.033
dehydroepiandrosterone
-
mutant Q105M, isoform 1, 27°C, pH 7.4
0.0623
dehydroepiandrosterone
-
mutant Q240R, isoform 1, 27°C, pH 7.4
0.0808
dehydroepiandrosterone
-
mutant Q105M, isoform 2, 27°C, pH 7.4
0.0884
dehydroepiandrosterone
-
wild-type, isoform 2, 27°C, pH 7.4
additional information
additional information
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-
-
additional information
additional information
-
kinetics
-
additional information
additional information
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kinetics
-
additional information
additional information
kinetics of wild-type and mutant enzymes
-
additional information
additional information
kinetics of wild-type and mutant enzymes
-
additional information
additional information
-
kinetics of wild-type and mutant enzymes
-
additional information
additional information
-
Km-values of mutant enzymes Y16F and D40N
-
additional information
additional information
thermodynamic parameters and rate constants for isomerization of 5-androstene-3,17-dione
-