5.3.3.1: steroid DELTA-isomerase

This is an abbreviated version!
For detailed information about steroid DELTA-isomerase, go to the full flat file.

Word Map on EC 5.3.3.1

5.3.3.1

steroidogenic

progesterone

adrenal

steroidogenesis

androgen

p450scc

leydig

star

testicular

pregnenolone

17beta-hsd

lh

aromatase

5-3-ketosteroids

gonad

testosteroni

granulosa

dehydroepiandrosterone

luteal

androstenedione

17beta-hydroxysteroid

dheas

theca

p450arom

17alpha-hydroxylase

neurosteroids

cyp11a1

trilostane

19-nortestosterone

dienolate

5alpha-reductase

equilenin

low-barrier

17alpha-hydroxylase/17,20-lyase

interna

3betahsd

delta5-3beta-hydroxysteroid

intracrine

double-bond

hsd3b1

talalay

20alpha-hsd

beta-proton

Reaction

Synonyms

3-Keto-DELTA5-steroid isomerase, 3-Ketosteroid DELTA5-->DELTA4-isomerase, 3-ketosteroid isomerase, 3-Oxo steroid DELTA4-DELTA5-isomerase, 3-Oxo-delta5 steroid isomerase, 3-oxo-DELTA5-steroid isomerase, 3-Oxosteroid DELTA4-DELTA5-isomerase, 3-Oxosteroid DELTA5-DELTA4-isomerase, 3-Oxosteroid isomerase, 3beta-HSD, 3beta-HSD/isomerase, 3beta-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase, 3beta-hydroxysteroid dehydrogenase/DELTA5-DELTA4 isomerase, 3beta-hydroxysteroid dehydrogenase/isomerase, 3beta-hydroxysteroid dehydrogenase/isomerase type 1, 3beta-hydroxysteroid dehydrogenase/isomerase type 2, 3KSI, 5-Ene-4-ene isomerase, 5-Pregnene-3,20-dione isomerase, delta 5-3-ketosteroid isomerase, DELTA-3-ketosteroid isomerase, Delta-5-3-ketosteroid isomerase, DELTA5(or DELTA4)-3-keto steroid isomerase, DELTA5-3-keto steroid isomerase, DELTA5-3-ketosteroid isomerase, DELTA5-3-oxosteroid isomerase, DELTA5-ketosteroid isomerase, DELTA5-steroid isomerase, glutathione transferase A3-3, GST A3-3, Hydroxysteroid isomerase, Isomerase, steroid DELTA, ketosteroid isomerase, KSI, More, Steroid 5-->4-isomerase, Steroid isomerase, TI, TI-WT, type I 3beta-hydroxysteroid dehydrogenase/isomerase

ECTree

5 Isomerases

5.3 Intramolecular oxidoreductases

5.3.3 Transposing C=C bonds

5.3.3.1 steroid DELTA-isomerase

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Results	in table
1	Activating Compound
410	AA Sequence
1	CAS Registry Number
17	Cloned(Commentary)
7	Cofactor
25	Crystallization (Commentary)
270	Disease/ Diagnostics
1	Expression
1	General Information
5	General Stability
5	IC50 Value
72	Inhibitors
7	kcat/KM [mM/s]
22	Ki Value [mM]
99	KM Value [mM]
10	Localization
25	Molecular Weight [Da]
16	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
98	Organism
16	Pathway
196	PDB ID
8	pH Optimum
3	pH Range
90	Protein Variants
25	Purification (Commentary)
7	Reaction
4	Reaction Type
97	Reference
8	Renatured (Commentary)
41	Source Tissue
6	Specific Activity [micromol/min/mg]
4	Storage Stability
91	Substrates and Products (Substrate)
15	Subunits
112	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
1	Temperature Range [°C]
3	Temperature Stability [°C]
86	Turnover Number [1/s]

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Turnover Number on EC 5.3.3.1 - steroid DELTA-isomerase

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70.8

17beta-Hydroxy-5(10)-estren-3-one

Comamonas testosteroni

2881

0.25 - 11.1

5(10)-estrene-3,17-dione

5 entries

0.052 - 288000

5-androstene-3,17-dione

65 entries

1.2 - 17800

androstene-3,17-dione

7 entries

1990 - 4890

dehydroepiandrosterone

6 entries

0.303

DELTA5-pregnen-3,20-dione

Bos taurus

25°C, pH 7.5

389390

additional information

Pseudomonas putida

turnover number of mutant enzymes Y16F and D40N

651623