5.3.3.1: steroid DELTA-isomerase

This is an abbreviated version!
For detailed information about steroid DELTA-isomerase, go to the full flat file.

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Synonyms

3-Keto-DELTA5-steroid isomerase, 3-Ketosteroid DELTA5-->DELTA4-isomerase, 3-ketosteroid isomerase, 3-Oxo steroid DELTA4-DELTA5-isomerase, 3-Oxo-delta5 steroid isomerase, 3-oxo-DELTA5-steroid isomerase, 3-Oxosteroid DELTA4-DELTA5-isomerase, 3-Oxosteroid DELTA5-DELTA4-isomerase, 3-Oxosteroid isomerase, 3beta-HSD, 3beta-HSD/isomerase, 3beta-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase, 3beta-hydroxysteroid dehydrogenase/DELTA5-DELTA4 isomerase, 3beta-hydroxysteroid dehydrogenase/isomerase, 3beta-hydroxysteroid dehydrogenase/isomerase type 1, 3beta-hydroxysteroid dehydrogenase/isomerase type 2, 3KSI, 5-Ene-4-ene isomerase, 5-Pregnene-3,20-dione isomerase, delta 5-3-ketosteroid isomerase, DELTA-3-ketosteroid isomerase, Delta-5-3-ketosteroid isomerase, DELTA5(or DELTA4)-3-keto steroid isomerase, DELTA5-3-keto steroid isomerase, DELTA5-3-ketosteroid isomerase, DELTA5-3-oxosteroid isomerase, DELTA5-ketosteroid isomerase, DELTA5-steroid isomerase, glutathione transferase A3-3, GST A3-3, Hydroxysteroid isomerase, Isomerase, steroid DELTA, ketosteroid isomerase, KSI, More, Steroid 5-->4-isomerase, Steroid isomerase, TI, TI-WT, type I 3beta-hydroxysteroid dehydrogenase/isomerase

ECTree

     5 Isomerases

         5.3 Intramolecular oxidoreductases

             5.3.3 Transposing C=C bonds

                5.3.3.1 steroid DELTA-isomerase

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Results	in table
1	Activating Compound
410	AA Sequence
1	CAS Registry Number
17	Cloned(Commentary)
7	Cofactor
25	Crystallization (Commentary)
270	Disease/ Diagnostics
1	Expression
1	General Information
5	General Stability
5	IC50 Value
72	Inhibitors
7	kcat/KM [mM/s]
22	Ki Value [mM]
99	KM Value [mM]
10	Localization
25	Molecular Weight [Da]
16	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
98	Organism
16	Pathway
196	PDB ID
8	pH Optimum
3	pH Range
90	Protein Variants
25	Purification (Commentary)
7	Reaction
4	Reaction Type
97	Reference
8	Renatured (Commentary)
41	Source Tissue
6	Specific Activity [micromol/min/mg]
4	Storage Stability
91	Substrates and Products (Substrate)
15	Subunits
112	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
1	Temperature Range [°C]
3	Temperature Stability [°C]
86	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 5.3.3.1 - steroid DELTA-isomerase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

5-Androstene-3,17-dione

4-Androstene-3,17-dione

3 entries

a 3-oxo-DELTA5-steroid

a 3-oxo-DELTA4-steroid

5 entries

additional information

?

-

8 entries

5-Androstene-3,17-dione

4-Androstene-3,17-dione

Comamonas testosteroni

-

-

727480

-

-

?

5-Androstene-3,17-dione

4-Androstene-3,17-dione

Comamonas testosteroni

P00947

-

678842, 678846, 678900

-

-

?

5-Androstene-3,17-dione

4-Androstene-3,17-dione

Pseudomonas sp.

-

-

682871

-

-

?

a 3-oxo-DELTA5-steroid

a 3-oxo-DELTA4-steroid

Comamonas testosteroni

-

-

682479

-

-

r

a 3-oxo-DELTA5-steroid

a 3-oxo-DELTA4-steroid

Digitalis lanata

-

-

749396

-

-

?

a 3-oxo-DELTA5-steroid

a 3-oxo-DELTA4-steroid

Pseudomonas putida

-

-

749297

-

-

?

a 3-oxo-DELTA5-steroid

a 3-oxo-DELTA4-steroid

Pseudomonas putida

-

-

682479

-

-

r

a 3-oxo-DELTA5-steroid

a 3-oxo-DELTA4-steroid

Pseudomonas putida

P07445

-

748025

-

-

?

additional information

?

-

Homo sapiens

-

in pregnancy placental 3beta-hydroxy-5-ene-steroid dehydrogenase and steroid 5--4 isomerase produce progesterone from pregnenolone and metabolize fetal dehydroepiandrosterone sulfate to androstenedione, an estrogen precursor

2899

-

-

?

additional information

?

-

Homo sapiens

-

the conversion of 3beta-hydroxy-5-ene steroids by the enzyme complex 3beta-hydroxysteroid dehydrogenase/DELTA5-DELTA4 isomerase is an obligatory step in the biosynthesis of all classes of hormonal steroids in classical steroidogenic as well as in peripheral tissues

2906

-

-

?

additional information

?

-

Homo sapiens

P14060

the bifunctional enzyme possesses 3beta-hydroxysteroid dehydrogenase activity, EC 1.1.1.51, and steroid DELTA-isomerase activity, the enzyme is a key steroidogenic enzyme that catalyzes the first step of the multienzyme pathway conversion of circulating dehydroepiandrosterone and pregnenolone to active steroid hormones

670028

-

-

?

additional information

?

-

Homo sapiens

P26439

the bifunctional enzyme possesses 3beta-hydroxysteroid dehydrogenase activity, EC 1.1.1.51, and steroid DELTA-isomerase activity, the enzyme is a key steroidogenic enzyme that catalyzes the first step of the multienzyme pathway conversion of circulating dehydroepiandrosterone and pregnenolone to active steroid hormones

670028

-

-

?

additional information

?

-

Homo sapiens

-

the bifunctional enzyme possesses 3beta-hydroxysteroid dehydrogenase activity, EC 1.1.1.51, and steroid DELTA-isomerase activity, the enzyme is a key steroidogenic enzyme that catalyzes the first step of the multienzyme pathway conversion of circulating dehydroepiandrosterone and pregnenolone to active steroid hormones

670028

-

-

?

additional information

?

-

Macaca mulatta

-

the conversion of 3beta-hydroxy-5-ene steroids by the enzyme complex 3beta-hydroxysteroid dehydrogenase/DELTA5-DELTA4 isomerase is an obligatory step in the biosynthesis of all classes of hormonal steroids in classical steroidogenic as well as in peripheral tissues

2898

-

-

?

additional information

?

-

Pseudomonas putida

-

enzyme can be induced by various steroids

2888

-

-

?

additional information

?

-

Taeniopygia guttata

-

the enzyme is involved in synthesis of sex steroids influencing the development and function of the songbird brain, overview

673822

-

-

?