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5.1.99.4: alpha-methylacyl-CoA racemase

This is an abbreviated version!
For detailed information about alpha-methylacyl-CoA racemase, go to the full flat file.

Word Map on EC 5.1.99.4

Reaction

(2S)-2-methylacyl-CoA
=
(2R)-2-methylacyl-CoA

Synonyms

2-arylpropionyl-CoA epimerase, 2-methylacyl-CoA racemase, alpha-methyl CoA racemase, alpha-Methylacyl CoA racemase, alpha-methylacyl coenzyme A racemase, alpha-methylacyl-CoA racemase, alpha-methylacyl-CoA racemase 1A, alpha-methylacyl-coenzyme A racemase, AMACR, AMACR 1A, AMACR IA, amacr/P504S, GenBank U89905-derived protein GI2145184, GenBank U89906-derived protein GI 2145186, ibuprofenoyl-CoA epimerase, MCR, P504S, Racemase, alpha-methylacyl coenzyme A, Racemase, alpha-methylacyl coenzyme A (Mus musculus clone 3), Racemase, alpha-methylacyl coenzyme A (Rattus norvegicus clone 11)

ECTree

     5 Isomerases
         5.1 Racemases and epimerases
             5.1.99 Acting on other compounds
                5.1.99.4 alpha-methylacyl-CoA racemase

Engineering

Engineering on EC 5.1.99.4 - alpha-methylacyl-CoA racemase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C297A
-
mutant with 6.2% relative enzyme activity
D127A
-
mutant with 21.6% relative enzyme activity
D156A
-
mutant with 17.6% relative enzyme activity
D185A
-
mutant with 68.5% relative enzyme activity
D190A
-
mutant with 3.3% relative enzyme activity
D231A
-
mutant with 25.0% relative enzyme activity
D28A
-
mutant with 24.2% relative enzyme activity
D60A
-
mutant with 22.7% relative enzyme activity
D78A
-
mutant with 44.0% relative enzyme activity
E241A
-
mutant with 2.1% relative enzyme activity
E306A
-
mutant with 23.1% relative enzyme activity
E82A
-
mutant with 12.5% relative enzyme activity
E90A
-
mutant with 67.0% relative enzyme activity
E97A
-
mutant with 95.4% relative enzyme activity
H126A
-
mutant with 4.5% relative enzyme activity
H312A
-
mutant with 10.1% relative enzyme activity
I56P
-
mutant with 28.8% relative enzyme activity
K62A
-
mutant with 117.6% relative enzyme activity
M111P
-
mutant with 5.2% relative enzyme activity
R175A
-
mutant with 63.6% relative enzyme activity
R38A
-
mutant with 20.9% relative enzyme activity
R52A
-
mutant with 15.7% relative enzyme activity
R54A
-
mutant with 37.4% relative enzyme activity
R85A
-
mutant with 20.3% relative enzyme activity
R91A
-
mutant with 19.9% relative enzyme activity, 9fold increase of Km compared with the wild type
Y130A
-
mutant with 24.7% relative enzyme activity
Y224A
-
mutant with 22.6% relative enzyme activity
Y227A
-
mutant with 20.1% relative enzyme activity