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5.1.99.4: alpha-methylacyl-CoA racemase

This is an abbreviated version!
For detailed information about alpha-methylacyl-CoA racemase, go to the full flat file.

Word Map on EC 5.1.99.4

Reaction

(2S)-2-methylacyl-CoA
=
(2R)-2-methylacyl-CoA

Synonyms

2-arylpropionyl-CoA epimerase, 2-methylacyl-CoA racemase, alpha-methyl CoA racemase, alpha-Methylacyl CoA racemase, alpha-methylacyl coenzyme A racemase, alpha-methylacyl-CoA racemase, alpha-methylacyl-CoA racemase 1A, alpha-methylacyl-coenzyme A racemase, AMACR, AMACR 1A, AMACR IA, amacr/P504S, GenBank U89905-derived protein GI2145184, GenBank U89906-derived protein GI 2145186, ibuprofenoyl-CoA epimerase, MCR, P504S, Racemase, alpha-methylacyl coenzyme A, Racemase, alpha-methylacyl coenzyme A (Mus musculus clone 3), Racemase, alpha-methylacyl coenzyme A (Rattus norvegicus clone 11)

ECTree

     5 Isomerases
         5.1 Racemases and epimerases
             5.1.99 Acting on other compounds
                5.1.99.4 alpha-methylacyl-CoA racemase

KM Value

KM Value on EC 5.1.99.4 - alpha-methylacyl-CoA racemase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.048 - 0.071
(2R)-ibuprofenoyl-CoA
0.277
(2S)-2-methyldecanoyl-CoA
-
pH and temperature not specified in the publication
0.086 - 0.087
(2S)-ibuprofenoyl-CoA
0.277 - 1.2
(R)-2-methyldecanoyl-CoA
0.041
(R)-pristanoyl-CoA
-
wild type
0.614 - 1.2
(S)-2-methyldecanoyl-CoA
0.052
(S)-ketoprofenoyl-CoA
-
pH and temperature not specified in the publication
0.068
(S)-naproxenoyl-CoA
-
pH and temperature not specified in the publication
0.021
3-fluoro-2-methyldecanoyl-CoA
-
anti-enantiomer, pH not specified in the publication, temperature not specified in the publication
0.076 - 0.172
pristanoyl-CoA
0.0316 - 0.06
trihydroxycoprostanoyl-CoA
additional information
additional information
-
similar Km values for mutants H126A, D156A and E241A as for the wild-type
-