5.1.99.4: alpha-methylacyl-CoA racemase
This is an abbreviated version!
For detailed information about alpha-methylacyl-CoA racemase, go to the full flat file.
Word Map on EC 5.1.99.4
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5.1.99.4
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prostate
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adenocarcinoma
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papillary
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cytokeratins
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high-grade
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gleason
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prostatectomy
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neoplasia
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needle
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clinicopathologic
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vimentin
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intraepithelial
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prostate-specific
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eosinophilic
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urothelial
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acinar
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pathologist
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immunophenotype
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34betae12
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hgpin
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chromophobe
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atypia
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pristanic
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oncocytic
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suspicious
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oncocytomas
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transurethral
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nucleoli
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drug development
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tmprss2-erg
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metanephric
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fuhrman
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immunomarkers
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chrcc
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cribriform
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analysis
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nephrogenic
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medicine
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psammoma
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pharmacology
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sarcomatoid
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hobnail
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tubulocystic
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immunoprofile
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adenosis
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phytanic
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diagnostics
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tubulopapillary
- 5.1.99.4
- prostate
- adenocarcinoma
-
papillary
-
cytokeratins
-
high-grade
-
gleason
-
prostatectomy
- neoplasia
-
needle
-
clinicopathologic
- vimentin
-
intraepithelial
-
prostate-specific
-
eosinophilic
-
urothelial
-
acinar
-
pathologist
-
immunophenotype
-
34betae12
-
hgpin
-
chromophobe
-
atypia
-
pristanic
-
oncocytic
-
suspicious
- oncocytomas
-
transurethral
-
nucleoli
- drug development
-
tmprss2-erg
-
metanephric
-
fuhrman
-
immunomarkers
-
chrcc
-
cribriform
- analysis
-
nephrogenic
- medicine
-
psammoma
- pharmacology
-
sarcomatoid
-
hobnail
-
tubulocystic
-
immunoprofile
-
adenosis
-
phytanic
- diagnostics
-
tubulopapillary
Reaction
Synonyms
2-arylpropionyl-CoA epimerase, 2-methylacyl-CoA racemase, alpha-methyl CoA racemase, alpha-Methylacyl CoA racemase, alpha-methylacyl coenzyme A racemase, alpha-methylacyl-CoA racemase, alpha-methylacyl-CoA racemase 1A, alpha-methylacyl-coenzyme A racemase, AMACR, AMACR 1A, AMACR IA, amacr/P504S, GenBank U89905-derived protein GI2145184, GenBank U89906-derived protein GI 2145186, ibuprofenoyl-CoA epimerase, MCR, P504S, Racemase, alpha-methylacyl coenzyme A, Racemase, alpha-methylacyl coenzyme A (Mus musculus clone 3), Racemase, alpha-methylacyl coenzyme A (Rattus norvegicus clone 11)
ECTree
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Reaction
Reaction on EC 5.1.99.4 - alpha-methylacyl-CoA racemase
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(2S)-2-methylacyl-CoA = (2R)-2-methylacyl-CoA
reaction mechanism, overview, the catalysis of the 1,1-proton transfer by alpha-methyl-acyl-CoA racemase is coupled to a movement of the fatty acyl moiety over a hydrophobic, methionine-rich surface, the mechanism involves the acid/base-pair residues His126 and Asp156, active site geometry, the thioester oxygen atom and the 2-methyl group are in a cisconformation with respect to each other, the thioester oxygen atom fits into an oxyanion hole and the 2-methyl group points into a hydrophobic pocket, Asp127A is a prominent residue in the active site and is located at the bottom of the catalytic site