4.99.1.8: heme ligase
This is an abbreviated version!
For detailed information about heme ligase, go to the full flat file.
Word Map on EC 4.99.1.8
-
4.99.1.8
-
plasmodium
-
malaria
-
hemozoin
-
falciparum
-
hemoglobin
-
antimalarial
-
vacuole
-
chloroquine
-
detoxify
-
medicine
-
artemisinins
-
reductase-thymidylate
-
byproduct
-
dihydrofolate
-
heme-binding
-
polymerization
-
yoelii
-
analysis
- 4.99.1.8
- plasmodium
- malaria
- hemozoin
- falciparum
- hemoglobin
-
antimalarial
- vacuole
- chloroquine
-
detoxify
- medicine
- artemisinins
-
reductase-thymidylate
-
byproduct
- dihydrofolate
-
heme-binding
- polymerization
- yoelii
- analysis
Reaction
2 ferriprotoporphyrin IX
=
Synonyms
alpha-HDP, HDP, heme detoxification protein, heme-detoxification protein
ECTree
4.99.1.8 heme ligaseAdvanced search results
results (
results (Inhibitors
Inhibitors on EC 4.99.1.8 - heme ligase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
diethyldicarbonate
histidine modification using diethyldicarbonate leads to reduction in heme binding and hemozoin formation
N-[2-[(7-methyl-2,3-dihydro-1H-inden-4-yl)oxy]-3-pyridinyl]-3,4-dihydro-2H-1,5-benzodioxepine-7-carboxamide
compound binds the modeled HDP structure in the heme/hemoglobin-binding pockets, and inhibits parasite growth in a dose-dependent manner
additional information
not inhibitory up to 0.04 mM: pyrimethamine
-
