4.99.1.8: heme ligase
This is an abbreviated version!
For detailed information about heme ligase, go to the full flat file.
Word Map on EC 4.99.1.8
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4.99.1.8
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plasmodium
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malaria
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hemozoin
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falciparum
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hemoglobin
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antimalarial
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vacuole
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chloroquine
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detoxify
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medicine
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artemisinins
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reductase-thymidylate
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byproduct
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dihydrofolate
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heme-binding
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polymerization
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yoelii
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analysis
- 4.99.1.8
- plasmodium
- malaria
- hemozoin
- falciparum
- hemoglobin
-
antimalarial
- vacuole
- chloroquine
-
detoxify
- medicine
- artemisinins
-
reductase-thymidylate
-
byproduct
- dihydrofolate
-
heme-binding
- polymerization
- yoelii
- analysis
Reaction
Synonyms
alpha-HDP, HDP, heme detoxification protein, heme-detoxification protein
ECTree
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Reference
Reference on EC 4.99.1.8 - heme ligase
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Vinayak, S.; Rathore, D.; Kariuki, S.; Slutsker, L.; Shi, Y.P.; Villegas, L.; Escalante, A.A.; Udhayakumar, V.
Limited genetic variation in the Plasmodium falciparum heme detoxification protein (HDP)
Infect. Genet. Evol.
9
286-289
2009
Plasmodium falciparum
Jani, D.; Nagakatti, R.; Beatty, W.; Angel, R.; Slebodnick, C.; Andersen, J.; Kumar, S.; Rathore, D.
HDP - a novel heme detoxification protein from the malaria parasite
PLos Pathog.
4
e1000053
2008
Plasmodium falciparum, Plasmodium yoelii
Slater, A.F.G.; Swiggard, W.J.; Orton, B.R.; Flitter, W.D.; Goldberg, D.E.; Cerami, A.; Henderson, G.B.
An iron-carboxylate bond links the heme units of malaria pigment
Proc. Natl. Acad. Sci. USA
88
325-329
1991
Plasmodium falciparum
Wagner, H.
Hemozoin: malaria's built-in adjuvant and TLR9 agonist
Cell Host Microbe
7
5-6
2010
Plasmodium falciparum
Shio, M.; Kassa, F.; Bellemare, M.; Olivier, M.
Innate inflammatory response to the malarial pigment hemozoin
Microbes Infect.
12
889-899
2010
Plasmodium falciparum
Nakatani, K.; Ishikawa, H.; Aono, S.; Mizutani, Y.
Heme-binding properties of heme detoxification protein from Plasmodium falciparum
Biochem. Biophys. Res. Commun.
439
477-480
2013
Plasmodium falciparum (Q8IL04), Plasmodium falciparum
Kattenberg, J.H.; Versteeg, I.; Migchelsen, S.J.; Gonzalez, I.J.; Perkins, M.D.; Mens, P.F.; Schallig, H.D.
New developments in malaria diagnostics: monoclonal antibodies against Plasmodium dihydrofolate reductase-thymidylate synthase, heme detoxification protein and glutamate rich protein
mAbs
4
120-126
2012
Plasmodium falciparum (Q8IL04), Plasmodium falciparum, Plasmodium falciparum NF54 (Q8IL04)
Chugh, M.; Sundararaman, V.; Kumar, S.; Reddy, V.S.; Siddiqui, W.A.; Stuart, K.D.; Malhotra, P.
Protein complex directs hemoglobin-to-hemozoin formation in Plasmodium falciparum
Proc. Natl. Acad. Sci. USA
110
5392-5397
2013
Plasmodium falciparum (Q8IL04), Plasmodium falciparum
Nakatani, K.; Ishikawa, H.; Aono, S.; Mizutani, Y.
Identification of essential histidine residues involved in heme binding and hemozoin formation in heme detoxification protein from Plasmodium falciparum
Sci. Rep.
4
6137
2014
Plasmodium falciparum (Q8IL04), Plasmodium falciparum
Soni, A.; Goyal, M.; Prakash, K.; Bhardwaj, J.; Siddiqui, A.J.; Puri, S.K.
Cloning, expression and functional characterization of heme detoxification protein (HDP) from the rodent malaria parasite Plasmodium vinckei
Gene
566
109-119
2015
Plasmodium vinckei petteri (F5BWX4)
Gupta, P.; Mehrotra, S.; Sharma, A.; Chugh, M.; Pandey, R.; Kaushik, A.; Khurana, S.; Srivastava, N.; Srivastava, T.; Deshmukh, A.; Panda, A.; Aggarwal, P.; Bhavesh, N.S.; Bhatnagar, R.K.; Mohmmed, A.; Gupta, D.; Malhotra, P.
Exploring heme and hemoglobin binding regions of Plasmodium heme detoxification protein for new antimalarial discovery
J. Med. Chem.
60
8298-8308
2017
Plasmodium falciparum (Q8IL04)
Kapishnikov, S.; Grolimund, D.; Schneider, G.; Pereiro, E.; McNally, J.; Als-Nielsen, J.; Leiserowitz, L.
Unraveling heme detoxification in the malaria parasite by in situ correlative X-ray fluorescence microscopy and soft X-ray tomography
Sci. Rep.
7
7610
2017
Plasmodium falciparum (Q8IL04), Plasmodium falciparum
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