4.99.1.8: heme ligase
This is an abbreviated version!
For detailed information about heme ligase, go to the full flat file.
Word Map on EC 4.99.1.8
-
4.99.1.8
-
plasmodium
-
malaria
-
hemozoin
-
falciparum
-
hemoglobin
-
antimalarial
-
vacuole
-
chloroquine
-
detoxify
-
medicine
-
artemisinins
-
reductase-thymidylate
-
byproduct
-
dihydrofolate
-
heme-binding
-
polymerization
-
yoelii
-
analysis
- 4.99.1.8
- plasmodium
- malaria
- hemozoin
- falciparum
- hemoglobin
-
antimalarial
- vacuole
- chloroquine
-
detoxify
- medicine
- artemisinins
-
reductase-thymidylate
-
byproduct
- dihydrofolate
-
heme-binding
- polymerization
- yoelii
- analysis
Reaction
2 ferriprotoporphyrin IX
=
Synonyms
alpha-HDP, HDP, heme detoxification protein, heme-detoxification protein
ECTree
4.99.1.8 heme ligaseAdvanced search results
results (
results (Natural Substrates Products
Natural Substrates Products on EC 4.99.1.8 - heme ligase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ferriprotoporphyrin IX
beta-hematin
-
hemozoin consists of an unusual polymer of hemes linked between the central ferric ion of one heme and a carboxylate side-group oxygen of another. The hemes are sequestered via this linkage into an insoluble product, providing a unique way for the malaria parasite to avoid the toxicity associated with soluble heme
-
-
?
