4.99.1.8: heme ligase
This is an abbreviated version!
For detailed information about heme ligase, go to the full flat file.
Word Map on EC 4.99.1.8
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4.99.1.8
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plasmodium
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malaria
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hemozoin
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falciparum
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hemoglobin
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antimalarial
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vacuole
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chloroquine
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detoxify
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medicine
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artemisinins
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reductase-thymidylate
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byproduct
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dihydrofolate
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heme-binding
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polymerization
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yoelii
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analysis
- 4.99.1.8
- plasmodium
- malaria
- hemozoin
- falciparum
- hemoglobin
-
antimalarial
- vacuole
- chloroquine
-
detoxify
- medicine
- artemisinins
-
reductase-thymidylate
-
byproduct
- dihydrofolate
-
heme-binding
- polymerization
- yoelii
- analysis
Reaction
Synonyms
alpha-HDP, HDP, heme detoxification protein, heme-detoxification protein
ECTree
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Engineering
Engineering on EC 4.99.1.8 - heme ligase
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H192A
the mutant shows decreased hemozoin formation activity compared to the wild type enzyme
H44A
the mutant shows decreased hemozoin formation activity compared to the wild type enzyme
H44A/H58A/H70A/H79A/H122A/H172A/H175A/H192A/H197A
the mutant shows less than half of the wild type activity
H58A
the mutant shows decreased hemozoin formation activity compared to the wild type enzyme
H70A
the mutant shows decreased hemozoin formation activity compared to the wild type enzyme
H79A
the mutant shows decreased hemozoin formation activity compared to the wild type enzyme
additional information
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the truncated enzyme proteins HDP3 (encoded by amino acids 88-205 of the full-length protein, representing the fasciclin domain) and HDP2 (encoded by amino acids 187 and lacking the fasciclin domain) are unable to produce hemozoin. The full-length enzyme is required for heme binding and hemozoin production activities of the protein