4.99.1.8: heme ligase
This is an abbreviated version!
For detailed information about heme ligase, go to the full flat file.
Word Map on EC 4.99.1.8
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4.99.1.8
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plasmodium
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malaria
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hemozoin
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falciparum
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hemoglobin
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antimalarial
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vacuole
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chloroquine
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detoxify
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medicine
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artemisinins
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reductase-thymidylate
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byproduct
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dihydrofolate
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heme-binding
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polymerization
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yoelii
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analysis
- 4.99.1.8
- plasmodium
- malaria
- hemozoin
- falciparum
- hemoglobin
-
antimalarial
- vacuole
- chloroquine
-
detoxify
- medicine
- artemisinins
-
reductase-thymidylate
-
byproduct
- dihydrofolate
-
heme-binding
- polymerization
- yoelii
- analysis
Reaction
Synonyms
alpha-HDP, HDP, heme detoxification protein, heme-detoxification protein
ECTree
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General Information
General Information on EC 4.99.1.8 - heme ligase
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physiological function
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hemozoin is the main protective mechanism against heme toxicity in malaria parasites
physiological function
identification of two heme binding sites and a hemoglobin binding site in Pf HDP. Treatment of Plasmodium falciparum 3D7 parasites with peptide corresponding to the hemoglobin binding domain results in food vacuole abnormalities similar to that seen with cysteine protease inhibitor, E-64
physiological function
non-crystalline heme is stored within hemoglobin in the digestive vacuole, and then converted to crystallized heme with the assistance of the heme detoxification protein. A coupling exists between the rate of hemoglobin digestion and the rate of heme dimerization and crystallization. In vivo heme crystallization occurs at a rate of about 1000/s, which is close to the in vitro rate of heme dimerization measured for the heme detoxification protein (HDP). HDP may be primarily responsible for heme crystallization