4.4.1.22: S-(hydroxymethyl)glutathione synthase

This is an abbreviated version!
For detailed information about S-(hydroxymethyl)glutathione synthase, go to the full flat file.

Reaction

Synonyms

EC 1.2.1.1, Gfa, glutathione-dependent formaldehyde-activating enzyme

ECTree

     4 Lyases

         4.4 Carbon-sulfur lyases

             4.4.1 Carbon-sulfur lyases (only sub-subclass identified to date)

                4.4.1.22 S-(hydroxymethyl)glutathione synthase

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Results	in table
2238	AA Sequence
1	CAS Registry Number
1	Cloned(Commentary)
2	Crystallization (Commentary)
3	General Information
2	Metals/Ions
1	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
3	Organism
6	Pathway
3	Purification (Commentary)
3	Reaction
1	Reaction Type
3	Reference
1	Specific Activity [micromol/min/mg]
5	Substrates and Products (Substrate)
1	Subunits
7	Synonyms
1	Systematic Name

Substrates Products

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Substrates Products on EC 4.4.1.22 - S-(hydroxymethyl)glutathione synthase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

5,6,7,8-tetrahydromethanopterin + formaldehyde

5,10-methylenetetrahydromethanopterin + H2O

Paracoccus denitrificans

Q51669

-

749071

-

-

?

glutathione + formaldehyde

S-(hydroxymethyl)glutathione

Paracoccus denitrificans

-

-

665643

-

-

?

S-(hydroxymethyl)glutathione

glutathione + formaldehyde

2 entries

additional information

?

-

2 entries

S-(hydroxymethyl)glutathione

glutathione + formaldehyde

Paracoccus denitrificans

-

-

656068

-

-

?

S-(hydroxymethyl)glutathione

glutathione + formaldehyde

Paracoccus denitrificans

-

the enzyme accelerates the spontaneous reaction in which the adduct of formaldehyde and glutathione is formed, i.e. the substrate for EC 1.1.1.284, S-(hydroxymethyl)glutathione dehydrogenase, in the formaldehyde-detoxification pathway

656068

-

-

?

additional information

?

-

Paracoccus denitrificans

Q51669

the enzyme glutathione-dependent formaldehyde-activating enzyme (GFA) from Paracoccus denitrificans catalyzes S-hydroxymethylglutathione (HMG) formation from glutathione and formaldehyde. Enzyme GFA binds glutathione but does not directly catalyse HMG formation under standard conditions. It is possible that GFA acts as a glutathione carrier that acts to co-localise glutathione and formaldehyde in a cellular context. NMR exchange spectroscopy is used for ligand identification. Glutathione binding structure, overview

749071

-

-

?

additional information

?

-

Paracoccus denitrificans

-

the enzyme glutathione-dependent formaldehyde-activating enzyme (GFA) from Paracoccus denitrificans catalyzes S-hydroxymethylglutathione (HMG) formation from glutathione and formaldehyde. Enzyme GFA binds glutathione but does not directly catalyse HMG formation under standard conditions. It is possible that GFA acts as a glutathione carrier that acts to co-localise glutathione and formaldehyde in a cellular context. NMR exchange spectroscopy is used for ligand identification. Glutathione binding structure, overview

749071

-

-

?