4.4.1.22: S-(hydroxymethyl)glutathione synthase
This is an abbreviated version!
For detailed information about S-(hydroxymethyl)glutathione synthase, go to the full flat file.
Word Map on EC 4.4.1.22
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4.4.1.22
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1.2.1.1
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s-hydroxymethylglutathione
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nad+
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dehydrogenases
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gfa
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paracoccus
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methanol
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denitrificans
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methylotrophic
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boidinii
- 4.4.1.22
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1.2.1.1
- s-hydroxymethylglutathione
- nad+
- dehydrogenases
- gfa
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paracoccus
- methanol
- denitrificans
-
methylotrophic
- boidinii
Reaction
Synonyms
EC 1.2.1.1, Gfa, glutathione-dependent formaldehyde-activating enzyme
ECTree
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Reaction
Reaction on EC 4.4.1.22 - S-(hydroxymethyl)glutathione synthase
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the enzyme from Paracoccus denitrificans accelerates the spontaneous reaction in which the adduct of formaldehyde and glutathione is formed, i.e. the substrate for EC 1.1.1.284, S-(hydroxymethyl)glutathione dehydrogenase, in the formaldehyde-detoxification pathway
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S-(hydroxymethyl)glutathione = glutathione + formaldehyde
GSH reacts with HCHO via its nucleophilic thiol group to form the intermediate S-hydroxymethylglutathione (HMG). The catalysis of enzyme glutathione-dependent formaldehyde-activating enzyme (GFA) is proposed to proceed via a highly unusual mechanism involving translocation of this second zinc ion to another undefined site on the protein. HMG formation is subsequently catalysed at this site before the zinc ion returns to the trigonal planar site after catalysis