4.2.1.114: methanogen homoaconitase
This is an abbreviated version!
For detailed information about methanogen homoaconitase, go to the full flat file.
Reaction
Synonyms
CNAG_02565, HacA, HACN, Homoaconitase, LYS4, methanogen HACN, MJ1003, MJ1271, More
ECTree
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General Information
General Information on EC 4.2.1.114 - methanogen homoaconitase
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malfunction
physiological function
Cryptococcus neoformans var. grubii serotype A
deletion of the CNAG_02565 gene results in lysine auxotrophy. The lys4 mutant shows increased sensitivity to oxidative stress, agents that challenge cell wall/membrane integrity, and azole antifungal drugs. The phenotype is due in part to impaired mitochondrial function as a result of LYS4 deletion, which disrupts iron homeostasis in the organelle. The lys4 mutant is attenuated virulence in a mouse inhalation model of cryptococcosis. Loss of the enzyme results in organelle dysfunction due to a potential impact on Fe-S levels
malfunction
Cryptococcus neoformans var. grubii serotype A H99 / ATCC 208821 / CBS 10515 / FGSC 9487
-
deletion of the CNAG_02565 gene results in lysine auxotrophy. The lys4 mutant shows increased sensitivity to oxidative stress, agents that challenge cell wall/membrane integrity, and azole antifungal drugs. The phenotype is due in part to impaired mitochondrial function as a result of LYS4 deletion, which disrupts iron homeostasis in the organelle. The lys4 mutant is attenuated virulence in a mouse inhalation model of cryptococcosis. Loss of the enzyme results in organelle dysfunction due to a potential impact on Fe-S levels
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Cryptococcus neoformans var. grubii serotype A
the enzyme expression is regulated by iron levels and by the iron-related transcription factors Hap3 and HapX. The enzyme is essential for lysine biosynthesis and is required for full virulence. The iron metabolism and homeostasis have a large influence on the virulence of Cryptococcus neoformans
physiological function
Cryptococcus neoformans var. grubii serotype A H99 / ATCC 208821 / CBS 10515 / FGSC 9487
-
the enzyme expression is regulated by iron levels and by the iron-related transcription factors Hap3 and HapX. The enzyme is essential for lysine biosynthesis and is required for full virulence. The iron metabolism and homeostasis have a large influence on the virulence of Cryptococcus neoformans
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