4.2.1.114: methanogen homoaconitase
This is an abbreviated version!
For detailed information about methanogen homoaconitase, go to the full flat file.
Reaction
Synonyms
CNAG_02565, HacA, HACN, Homoaconitase, LYS4, methanogen HACN, MJ1003, MJ1271, More
ECTree
4.2.1.114 methanogen homoaconitaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 4.2.1.114 - methanogen homoaconitase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(1E)-hex-1-ene-1,2,6-tricarboxylic acid + H2O
(2R)-hexane-1,2,6-tricarboxyclic acid
-
-
-
-
?
(1E)-pent-1-ene-1,2,5-tricarboxylic acid + H2O
(2R)-pentane-1,2,5-tricarboxylic acid
-
-
-
-
?
(2R)-butane-1,2,4-tricarboxylic acid
but-1-ene-1,2,4-tricarboxylic acid + H2O
-
-
-
-
?
(R)-2-hydroxybutane-1,2,4-tricarboxylate
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate
i.e. (R)-homocitrate, overall reaction, the enzyme catalyzes both the dehydration of (R)-homocitrate to form cis-homoaconitate, and hydration producing homoisocitrate
i.e. homoisocitrate
-
r
(R)-2-hydroxybutane-1,2,4-tricarboxylate + H2O
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate
but-1-ene-1,2,4-tricarboxylic acid + H2O
(2R)-butane-1,2,4-tricarboxylic acid
-
-
-
-
?
cis-(homo)2aconitate + H2O
(-)-threo-iso(homo)2citrate
-
-
-
?
cis-(homo)2aconitate + H2O
?
the activity is similar as with (R)-homocitrate
-
-
?
cis-(homo)3aconitate + H2O
(-)-threo-iso(homo)3citrate
-
-
-
?
cis-(homo)3aconitate + H2O
?
the activity is similar as with (R)-homocitrate
-
-
?
cis-(homo)4aconitate + H2O
?
the activity is similar as with (R)-homocitrate
-
-
?
(R)-2-hydroxybutane-1,2,4-tricarboxylate
(Z)-but-1-ene-1,2,4-tricarboxylate + H2O
Cryptococcus neoformans var. grubii serotype A
-
-
-
?
(R)-2-hydroxybutane-1,2,4-tricarboxylate
(Z)-but-1-ene-1,2,4-tricarboxylate + H2O
Cryptococcus neoformans var. grubii serotype A H99 / ATCC 208821 / CBS 10515 / FGSC 9487
-
-
-
?
(R)-2-hydroxybutane-1,2,4-tricarboxylate
(Z)-but-1-ene-1,2,4-tricarboxylate + H2O
i.e. (R)-homocitrate, first half-reaction
i.e. cis-homoaconitate, the activity in the reverse direction is similar as with (R)-homocitrate
-
r
(R)-2-hydroxybutane-1,2,4-tricarboxylate + H2O
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate
Cryptococcus neoformans var. grubii serotype A
-
-
-
?
(R)-2-hydroxybutane-1,2,4-tricarboxylate + H2O
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate
Cryptococcus neoformans var. grubii serotype A H99 / ATCC 208821 / CBS 10515 / FGSC 9487
-
-
-
?
(Z)-but-1-ene-1,2,4-tricarboxylate + H2O
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate
Cryptococcus neoformans var. grubii serotype A
-
-
-
?
(Z)-but-1-ene-1,2,4-tricarboxylate + H2O
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate
Cryptococcus neoformans var. grubii serotype A H99 / ATCC 208821 / CBS 10515 / FGSC 9487
-
-
-
?
(Z)-but-1-ene-1,2,4-tricarboxylate + H2O
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate
second half-reaction
i.e. homoisocitrate
-
r
additional information
?
-
-
homoaconitase enzymes catalyze hydrolyase reactions in the alpha-aminoadipate pathway for lysine biosynthesis or the 2-oxosuberate pathway for methanogenic coenzyme B biosynthesis
-
-
?
additional information
?
-
homoaconitase enzymes catalyze hydrolyase reactions in the alpha-aminoadipate pathway for lysine biosynthesis or the 2-oxosuberate pathway for methanogenic coenzyme B biosynthesis
-
-
?
additional information
?
-
-
homoaconitase together with the endogenous homoisocitrate dehydrogenase, EC 1.1.1.87, catalyze all of the isomerization and oxidative decarboxylation reactions required to form 2-oxoadipate, 2-oxopimelate, and 2-oxosuberate, completing three iterations of the 2-oxoacid elongation pathway. Methanogenic archaeal homoaconitases and fungal homoaconitases evolved in parallel in the aconitase superfamily, LC-MS analysis of enzyme reaction products, overview
-
-
?
additional information
?
-
homoaconitase together with the endogenous homoisocitrate dehydrogenase, EC 1.1.1.87, catalyze all of the isomerization and oxidative decarboxylation reactions required to form 2-oxoadipate, 2-oxopimelate, and 2-oxosuberate, completing three iterations of the 2-oxoacid elongation pathway. Methanogenic archaeal homoaconitases and fungal homoaconitases evolved in parallel in the aconitase superfamily, LC-MS analysis of enzyme reaction products, overview
-
-
?
additional information
?
-
-
HACN has no detectable activity with citraconate or isopropylmalate
-
-
?
