4.2.1.114: methanogen homoaconitase

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For detailed information about methanogen homoaconitase, go to the full flat file.

Reaction

Synonyms

CNAG_02565, HacA, HACN, Homoaconitase, LYS4, methanogen HACN, MJ1003, MJ1271, More

ECTree

     4 Lyases

         4.2 Carbon-oxygen lyases

             4.2.1 Hydro-lyases

                4.2.1.114 methanogen homoaconitase

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Results	in table
307	AA Sequence
2	Application
4	Cloned(Commentary)
1	Cofactor
2	Crystallization (Commentary)
2	Expression
4	General Information
6	Inhibitors
20	KM Value [mM]
2	Localization
4	Metals/Ions
9	Natural Substrates/ Products (Substrates)
7	Organism
7	Pathway
1	PDB ID
2	pH Optimum
6	Protein Variants
3	Purification (Commentary)
3	Reaction
7	Reference
24	Substrates and Products (Substrate)
1	Subunits
19	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
19	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 4.2.1.114 - methanogen homoaconitase

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SYSTEMATIC NAME

IUBMB Comments

(R)-2-hydroxybutane-1,2,4-tricarboxylate hydro-lyase [(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate-forming]

This enzyme catalyses several reactions in the pathway of coenzyme-B biosynthesis in methanogenic archaea. Requires a [4Fe-4S] cluster for activity. In contrast to EC 4.2.1.36, homoaconitate hydratase, this enzyme can catalyse both the dehydration of (R)-homocitrate to form cis-homoaconitate and the subsequent hydration reaction that forms homoisocitrate. In addition to cis-homoaconitate, the enzyme can also catalyse the hydration of the physiological substrates dihomoaconitate and trihomoaconitate as well as the non-physiological substrate tetrahomoaconitate. cis-Aconitate and threo-DL-isocitrate cannot act as substrates, and (S)-homocitrate and trans-homoaconitate act as inhibitors of the enzyme.