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4.1.3.43: 4-hydroxy-2-oxohexanoate aldolase

This is an abbreviated version!
For detailed information about 4-hydroxy-2-oxohexanoate aldolase, go to the full flat file.

Reaction

(S)-4-hydroxy-2-oxohexanoate
=
propanal
+
pyruvate

Synonyms

BphI, TTHB246

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.3 Oxo-acid-lyases
                4.1.3.43 4-hydroxy-2-oxohexanoate aldolase

Inhibitors

Inhibitors on EC 4.1.3.43 - 4-hydroxy-2-oxohexanoate aldolase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-oxobutanoate
-
competitive inhibition
2-oxopentanoate
-
competitive inhibition
4-methyl-2-oxopentanoate
-
competitive inhibition
Cd2+
56.0% activity at 0.1 mM and 5.4% activity at 1 mM chloride salt
Co2+
19.3% activity at 0.1 mM and 18.3% activity at 1 mM chloride salt
glyoxylate
-
competitive inhibition
Mg2+
3.4% activity at 0.1 mM and 14.8% activity at 1 mM chloride salt
Mn2+
100% activity at 0.1 mM and 1 mM chloride salt
Ni2+
2.6% activity at 0.1 mM and 17.5% activity at 1 mM chloride salt
pyruvate
-
competitive inhibition