4.1.3.43: 4-hydroxy-2-oxohexanoate aldolase

This is an abbreviated version!
For detailed information about 4-hydroxy-2-oxohexanoate aldolase, go to the full flat file.

Reaction

Synonyms

BphI, TTHB246

ECTree

     4 Lyases

         4.1 Carbon-carbon lyases

             4.1.3 Oxo-acid-lyases

                4.1.3.43 4-hydroxy-2-oxohexanoate aldolase

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Results	in table
1	Activating Compound
379	AA Sequence
6	Cloned(Commentary)
4	General Information
11	Inhibitors
89	kcat/KM [mM/s]
7	Ki Value [mM]
90	KM Value [mM]
1	Metals/Ions
10	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
6	Organism
8	Pathway
24	Protein Variants
3	Purification (Commentary)
1	Reaction
1	Reaction Type
6	Reference
1	Storage Stability
36	Substrates and Products (Substrate)
2	Subunits
6	Synonyms
1	Systematic Name
3	Temperature Stability [°C]
89	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 4.1.3.43 - 4-hydroxy-2-oxohexanoate aldolase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

(4R)-4-hydroxy-2-oxohexanoate

pyruvate + propionaldehyde

Paraburkholderia xenovorans

-

reaction catalyzed by BphI variants Y290F, L87N/Y290F and L87W/Y290F

722458

-

-

?

(4R)-4-hydroxy-2-oxopentanoate

pyruvate + acetaldehyde

Paraburkholderia xenovorans

-

-

714244, 722458

-

-

?

(4S)-4-hydroxy-2-oxohexanoate

pyruvate + propionaldehyde

Paraburkholderia xenovorans

-

double variants L87N/Y290F and L87W/Y290F inactive toward (4S)-4-hydroxy-2-oxohexanoate

722458

-

-

?

(4S)-4-hydroxy-2-oxopentanoate

acetaldehyde + pyruvate

Thermus thermophilus

Q53WI0

-

721659

-

-

?

(4S)-4-hydroxy-2-oxopentanoate

pyruvate + acetaldehyde

Paraburkholderia xenovorans

-

-

714244, 722458

-

-

?

(S)-4-hydroxy-2-oxohexanoate

propanal + pyruvate

Paraburkholderia xenovorans

P51015

-

721615

-

-

?

4-hydroxy-2-oxoheptanoate

pyruvate + butanal

Paraburkholderia xenovorans

P51015

-

721615

-

-

?

4-hydroxy-2-oxohexanoate

propanal + pyruvate

Thermus thermophilus

Q53WI0

-

721659

-

-

?

4-hydroxy-2-oxohexanoate

propionaldehyde + pyruvate

Paraburkholderia xenovorans

-

4-hydroxy-2-oxohexanoate i.e. HOHA

721651

-

-

?

4-hydroxy-2-oxohexanoate

pyruvate + propionaldehyde

Paraburkholderia xenovorans

P51015

-

721615

-

-

?

4-hydroxy-2-oxopentanoate

acetaldehyde + pyruvate

2 entries

4-hydroxy-2-oxopentanoate

pyruvate + acetaldehyde

Paraburkholderia xenovorans

P51015

-

721615

-

-

?

Oxaloacetate

CO2 + pyruvate

Paraburkholderia xenovorans

-

oxaloacetate decarboxylation is a secondary reaction of pyruvate aldolases

722458

-

-

?

Oxaloacetate

Pyruvate + CO2

Paraburkholderia xenovorans

P51015

-

721615

-

-

?

pyruvate + acetaldehyde

(4R)-4-hydroxy-2-oxopentanoate

Paraburkholderia xenovorans

-

-

714244, 722458

-

-

?

pyruvate + acetaldehyde

(4S)-4-hydroxy-2-oxopentanoate

Paraburkholderia xenovorans

-

-

702377, 714244, 722458

-

-

?

pyruvate + butyraldehyde

?

Paraburkholderia xenovorans

-

-

702377, 714244, 722458

-

-

?

pyruvate + glycolaldehyde

?

Paraburkholderia xenovorans

-

-

702377

-

-

?

pyruvate + hexaldehyde

?

Paraburkholderia xenovorans

-

-

714244

-

-

?

pyruvate + isobutyraldehyde

?

Paraburkholderia xenovorans

-

-

702377

-

-

?

pyruvate + pentaldehyde

?

Paraburkholderia xenovorans

-

-

702377, 714244, 722458

-

-

?

pyruvate + propionaldehyde

(4R)-4-hydroxy-2-oxohexanoate

Paraburkholderia xenovorans

-

reaction catalyzed by BphI variants Y290F and Y290S

714244

-

-

?

pyruvate + propionaldehyde

(4S)-4-hydroxy-2-oxohexanoate

Paraburkholderia xenovorans

-

-

714244

-

-

?

pyruvate + propionaldehyde

4-hydroxy-2-oxohexanoate

Paraburkholderia xenovorans

-

-

722458

-

-

?

pyruvate + propionaldehyde

?

Paraburkholderia xenovorans

-

-

702377

-

-

?

additional information

?

-

2 entries

4-hydroxy-2-oxopentanoate

acetaldehyde + pyruvate

Paraburkholderia xenovorans

-

4-hydroxy-2-oxopentanoate i.e. HOPA

721651

-

-

?

4-hydroxy-2-oxopentanoate

acetaldehyde + pyruvate

Thermus thermophilus

Q53WI0

-

721659

-

-

?

additional information

?

-

Thermus thermophilus

Q53WI0

no activity with (4R)-4-hydroxy-2-oxopentanoate

721659

-

-

?

additional information

?

-

Thermus thermophilus

-

no activity with (4R)-4-hydroxy-2-oxopentanoate

721659

-

-

?