Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

4.1.3.43: 4-hydroxy-2-oxohexanoate aldolase

This is an abbreviated version!
For detailed information about 4-hydroxy-2-oxohexanoate aldolase, go to the full flat file.

Reaction

(S)-4-hydroxy-2-oxohexanoate
=
propanal
+
pyruvate

Synonyms

BphI, TTHB246

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.3 Oxo-acid-lyases
                4.1.3.43 4-hydroxy-2-oxohexanoate aldolase

Systematic Name

Systematic Name on EC 4.1.3.43 - 4-hydroxy-2-oxohexanoate aldolase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
SYSTEMATIC NAME
IUBMB Comments
(S)-4-hydroxy-2-oxohexanoate pyruvate-lyase (propanal-forming)
Requires Mn2+ for maximal activity [1,2]. The enzymes from the bacteria Burkholderia xenovorans and Thermus thermophilus also perform the reaction of EC 4.1.3.39, 4-hydroxy-2-oxovalerate aldolase [1,2,6]. The enzyme forms a bifunctional complex with EC 1.2.1.87, propanal dehydrogenase (CoA-propanoylating), with a tight channel connecting the two subunits [3,4,6].