4.1.2.4: deoxyribose-phosphate aldolase
This is an abbreviated version!
For detailed information about deoxyribose-phosphate aldolase, go to the full flat file.
Word Map on EC 4.1.2.4
Reaction
Synonyms
2-deoxy-D-ribose 5-phosphate aldolase, 2-deoxy-D-ribose-5-phosphate aldolase, 2-deoxyribose 5-phosphate aldolase, 2-Deoxyribose-5-phosphate aldolase, aldolase, deoxyribo, CGI-26, D-2-deoxyribose-5-phosphate aldolase, d5RP aldolase, DeoC, Deoxyriboaldolase, deoxyribose 5-phosphate aldolase, deoxyribose phosphate aldolase-like protein, Deoxyribose-5-phosphate aldolase, deoxyribose-phosphate aldolase, DERA, DPA, DR aldolase, Phosphodeoxyriboaldolase, TgDERA, TgDPA, Tk-DeoC, TK2104, TtDERA
ECTree
4.1.2.4 deoxyribose-phosphate aldolaseAdvanced search results
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results (Inhibitors
Inhibitors on EC 4.1.2.4 - deoxyribose-phosphate aldolase
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
acrolein
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irreversible, no inactivation after prolonged incubation with glycidol phosphate and glycidaldehyde
Chloroacetaldehyde
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the enzyme is rapidly and irreversibly inactivated and loses 84.9% of its enzymatic activity in the presence of 200 mM chloroacetaldehyde
crotonaldehyde
the enzyme produces crotonaldehyde as side reaction from acetaldehyde which is then an irreversible inhibitor forming a covalent Michael-adduct within the active site in particular with cysteine 47
D-glyceraldehyde
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the activity of wild-type enzyme sharply dropps by 43 % under 200 mM D-glyceraldehyde and acetaldehyde, which limits its large-scale synthetic applications
p-hydroxymercuribenzoate
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2-mercaptoethanol or dithiothreitol prevent inactivation
acetaldehyde
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the activity of wild-type enzyme sharply dropps by 43 % under 200 mM D-glyceraldehyde and acetaldehyde, which limits its large-scale synthetic applications
acetaldehyde
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the wild type enzyme is highly resistant to high concentrations of acetaldehyde, whereas the recombinant DERA is almost completely inactivated after a 2 h exposure at 25°C
acetaldehyde
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the wild type enzyme is highly resistant to high concentrations of acetaldehyde
additional information
2-deoxy-D-ribose-5-phosphate-producing activity of the enzyme remains even at 300 mM acetaldehyde
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