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4.1.2.4: deoxyribose-phosphate aldolase

This is an abbreviated version!
For detailed information about deoxyribose-phosphate aldolase, go to the full flat file.

Word Map on EC 4.1.2.4

Reaction

2-deoxy-D-ribose 5-phosphate
=
D-glyceraldehyde 3-phosphate
+
acetaldehyde

Synonyms

2-deoxy-D-ribose 5-phosphate aldolase, 2-deoxy-D-ribose-5-phosphate aldolase, 2-deoxyribose 5-phosphate aldolase, 2-Deoxyribose-5-phosphate aldolase, aldolase, deoxyribo, CGI-26, D-2-deoxyribose-5-phosphate aldolase, d5RP aldolase, DeoC, Deoxyriboaldolase, deoxyribose 5-phosphate aldolase, deoxyribose phosphate aldolase-like protein, Deoxyribose-5-phosphate aldolase, deoxyribose-phosphate aldolase, DERA, DPA, DR aldolase, Phosphodeoxyriboaldolase, TgDERA, TgDPA, Tk-DeoC, TK2104, TtDERA

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.2 Aldehyde-lyases
                4.1.2.4 deoxyribose-phosphate aldolase

Crystallization

Crystallization on EC 4.1.2.4 - deoxyribose-phosphate aldolase

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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
hanging drop vapor diffusion method
crystals of native wild-type enzyme and SeMet enzyme are grown by vapor-diffusion sitting drop method, analysis of the class I aldolase binding site architecture based on the crystal structure of 2-deoxyribose-5-phosphate aldolase at 0.99 A resolution
hanging drop vapour diffusion method with 20% (w/v) polyethylene glycol 1000, 0.2 M zinc acetate, and 0.1 M acetate buffer (pH 4.5)
-
hanging drop vapor diffusion method, crystal structures of full length and C-terminal truncated enzyme is determined at 2.8 A resolution. Both contain the typical (alpha/beta)8 TIM-barrel fold of class I aldolases. C-terminal truncation resulting in missing the last alpha9 and beta8 secondary elements, allows the enzyme to maintain activity comparable to the full length enzyme. Arg186 and Ser205 residues at the C-terminus appear mutually supplemental or less indispensible for substrate phosphate moiety recognition
microbatch method, crystal structure of the enzyme and its complex with 2-deoxy-D-ribose 5-phosphate
-