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4.1.2.4: deoxyribose-phosphate aldolase

This is an abbreviated version!
For detailed information about deoxyribose-phosphate aldolase, go to the full flat file.

Word Map on EC 4.1.2.4

Reaction

2-deoxy-D-ribose 5-phosphate
=
D-glyceraldehyde 3-phosphate
+
acetaldehyde

Synonyms

2-deoxy-D-ribose 5-phosphate aldolase, 2-deoxy-D-ribose-5-phosphate aldolase, 2-deoxyribose 5-phosphate aldolase, 2-Deoxyribose-5-phosphate aldolase, aldolase, deoxyribo, CGI-26, D-2-deoxyribose-5-phosphate aldolase, d5RP aldolase, DeoC, Deoxyriboaldolase, deoxyribose 5-phosphate aldolase, deoxyribose phosphate aldolase-like protein, Deoxyribose-5-phosphate aldolase, deoxyribose-phosphate aldolase, DERA, DPA, DR aldolase, Phosphodeoxyriboaldolase, TgDERA, TgDPA, Tk-DeoC, TK2104, TtDERA

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.2 Aldehyde-lyases
                4.1.2.4 deoxyribose-phosphate aldolase

Substrates Products

Substrates Products on EC 4.1.2.4 - deoxyribose-phosphate aldolase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(R)-3-Bromo-2-hydroxypropanal + acetaldehyde
5-Bromo-2-deoxyribose
show the reaction diagram
(S)-4-chloro-3-hydroxybutanal + acetaldehyde
(3R,5S)-6-chloro-2,4,6-trideoxyhexapyranoside
show the reaction diagram
-
-
-
-
?
2-deoxy-D-ribose
D-glyceraldehyde + acetaldehyde
show the reaction diagram
2-deoxy-D-ribose 5-phosphate
?
show the reaction diagram
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
show the reaction diagram
2-deoxy-D-ribose-5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
show the reaction diagram
-
-
-
?
2-hydroxy-3-butenal + acetaldehyde
2,5,6-trideoxy-D-erythro-5-hexenose
show the reaction diagram
3-Azido-3-deoxy-erythrose + acetaldehyde
5-Azidohexofuranose
show the reaction diagram
-
-
-
?
3-azidopropanal + 2 acetaldehyde
(4R,6R)-6-(2-azidoethyl)-4-hydroxyoxan-2-one + 2 H+
show the reaction diagram
-
-
-
?
3-azidopropionaldehyde + acetaldehyde
(4R,6R)-4-hydroxy-6-(2-triaz-2-en-1-ylethyl)tetrahydro-2H-pyran-2-one
show the reaction diagram
-
no activity with wild-type enzyme, mutant enzyme S238D gives 35% yield of the sequential aldol condensation product
-
-
?
3-Chloro-2-hydroxypropanal + propionaldehyde
5-Chloro-2-methylribose
show the reaction diagram
3-chloropropionaldehyde + acetaldehyde
(4R,6S)-6-(2-chloroethyl)-4-hydroxytetrahydro-2H-pyran-2-one
show the reaction diagram
-
wild type enzyme gives 25% yield of the sequential aldol condensation product, mutant enzyme S238D gives 43% yield of the sequential aldol condensation product
-
-
?
3-Thioglyceraldehyde + acetaldehyde
2-Deoxy-5-thio-D-erythro-pentose
show the reaction diagram
-
-
-
?
5-O-(4'-methylumbelliferyl)-2-deoxy-D-ribose
3-O-(4'-methylumbelliferyl)-D-glyceraldehyde + acetaldehyde
show the reaction diagram
5-O-(4'-methylumbelliferyl)-2-deoxy-D-xylose
?
show the reaction diagram
5-O-(4'-methylumbelliferyl)-2-deoxy-L-ribose
?
show the reaction diagram
acetaldehyde + acetaldehyde
?
show the reaction diagram
enzyme directly immobilized through ionic exchange interactions on oxidized multiwalled carbon nanotubes catalyzes the reaction of acetaldehyde alone (self-condensation) or in the presence of chloro-acetaldehyde. The corresponding cyclic lactols are obtained in higher yield than with the native enzyme
-
-
?
chloroacetaldehyde + acetaldehyde
(S)-4-chloro-3-hydroxybutanal
show the reaction diagram
-
-
-
-
?
chloroacetaldehyde + acetaldehyde
?
show the reaction diagram
enzyme directly immobilized through ionic exchange interactions on oxidized multiwalled carbon nanotubes catalyzes the reaction of acetaldehyde alone (self-condensation) or in the presence of chloro-acetaldehyde. The corresponding cyclic lactols are obtained in higher yield than with the native enzyme
-
-
?
D-(R)-3-Azido-2-hydroxypropanal + acetaldehyde
5-Azido-(2R)-methyl-2,5-dideoxy-D-ribo-furanose
show the reaction diagram
-
-
-
?
D-(R)-3-Azido-2-hydroxypropanal + acetone
6-Azido-1,3,5-trideoxy-D-erythro-hexulose
show the reaction diagram
-
-
-
?
D-(R)-3-Azido-2-hydroxypropanal + fluoroacetone
6-Azido-1-fluoro-1,3,5-trideoxy-D-erythro-hexulose
show the reaction diagram
-
-
-
?
D-2-deoxyribose
glyceraldehyde + acetaldehyde
show the reaction diagram
-
good substrate for the S238D mutant, weak substrate for the wild-type enzyme
-
?
D-Erythrose + acetaldehyde
2,3,4,5-Trihydroxypentanal
show the reaction diagram
-
-
-
-
?
D-Erythrose 4-phosphate + acetaldehyde
?
show the reaction diagram
-
-
-
-
?
D-glyceraldehyde 3-phosphate + acetaldehyde
2-deoxy-D-ribose 5-phosphate
show the reaction diagram
D-Glyceraldehyde 3-phosphate + acetaldehyde
?
show the reaction diagram
D-glyceraldehyde 3-phosphate + propionaldehyde
2-methyl-2-deoxypentose phosphate
show the reaction diagram
D-ribose 5-phosphate
?
show the reaction diagram
-
-
-
-
?
Glyceraldehyde phosphate + acetaldehyde
Hydroxyacetaldehyde + glyceraldehyde 3-phosphate
show the reaction diagram
-
-
-
-
?
Isobutyraldehyde + acetone
(S)-4-Hydroxy-5-methylhexan-2-one
show the reaction diagram
-
-
-
?
Isobutyraldehyde + fluoroacetone
(S)-1-Fluoro-3-hydroxy-4-methylhexan-2-one
show the reaction diagram
-
-
-
?
L-Glyceraldehyde 3-phosphate + acetaldehyde
Glyceraldehyde + acetaldehyde
show the reaction diagram
additional information
?
-