4.1.2.4: deoxyribose-phosphate aldolase
This is an abbreviated version!
For detailed information about deoxyribose-phosphate aldolase, go to the full flat file.
Reaction
Synonyms
2-deoxy-D-ribose 5-phosphate aldolase, 2-deoxy-D-ribose-5-phosphate aldolase, 2-deoxyribose 5-phosphate aldolase, 2-Deoxyribose-5-phosphate aldolase, aldolase, deoxyribo, CGI-26, D-2-deoxyribose-5-phosphate aldolase, d5RP aldolase, DeoC, Deoxyriboaldolase, deoxyribose 5-phosphate aldolase, deoxyribose phosphate aldolase-like protein, Deoxyribose-5-phosphate aldolase, deoxyribose-phosphate aldolase, DERA, DPA, DR aldolase, Phosphodeoxyriboaldolase, TgDERA, TgDPA, Tk-DeoC, TK2104, TtDERA
ECTree
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General Information
General Information on EC 4.1.2.4 - deoxyribose-phosphate aldolase
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metabolism
physiological function
metabolism
the expression of deoxyribose-phosphate aldolase enables cells in which mitochondrial ATP production is abolished to make use of extracellular deoxyinosine to maintain ATP levels. This pathway may allow cells with high deoxyribose-phosphate aldolase activity, such as liver cells, to minimize or delay stress-induced damage by producing energy through deoxynucleoside degradation
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DERA catalyzes a sequential aldol reaction that is useful to synthesize a key fragment of atorvastatin
physiological function
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the organism responds to ciprofloxacin by controlling synthesis of enzymes, e.g. DeoC, with potential role in oxidative damage response and in nucleotide biosynthesis
physiological function
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Toxoplasma gondii deoxyribose phosphate aldolase-like protein interacts with actin depolymerizing factor to enhance the actin filament dynamics in the bradyzoite stage
physiological function
the enzyme is involved in stress response. The enzyme interacts with the stress granule component YBX1 and is recruited to stress granules after oxidative or mitochondrial stress
physiological function
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Toxoplasma gondii deoxyribose phosphate aldolase-like protein interacts with actin depolymerizing factor to enhance the actin filament dynamics in the bradyzoite stage
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