4.1.1.B12: lysine/ornithine carboxy-lyase
This is an abbreviated version!
For detailed information about lysine/ornithine carboxy-lyase, go to the full flat file.
Reaction
Synonyms
arginine/ornithine decarboxylase, HsLDC, L-lysine decarboxylase, L/ODC, LcL/ODC, LDC, LDC/ODC, Lys/Orn decarboxylase, lysine/ornithine decarboxylase, More, OAD, OAD1, SrLDC, vvLDC
ECTree
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Inhibitors
Inhibitors on EC 4.1.1.B12 - lysine/ornithine carboxy-lyase
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alpha-difluoromethylarginine
alpha-difluoromethylarginine also inhibits the enzyme and enhances the inhibitory effect of alpha-difluoromethylornithine from 14% to 20% inhibition at 5 mM
alpha-DFMO, a suicide inhibitor, at 5 mM for 72 h, it inhibits membrane-associated ODC activity. Following exposure to alpha-DFMO, the putrescine content in the cells declineds, while the norspermidine content increases over 2fold. Partial inhibition of putrescine synthesis by alpha-DFMO results in increased norspermidine production in the cells suggesting that the suicide inhibitor may also act as an abiotic stress agent
alpha-difluoromethylornithine
inhibitor of ornithine decarboxylase, inhibitory
alpha-difluoromethylornithine
ornithine decarboxylase suicide inhibitor, dose-dependent inhibition of both lysine and ornthine decarboxylase activities