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4.1.1.33: diphosphomevalonate decarboxylase

This is an abbreviated version!
For detailed information about diphosphomevalonate decarboxylase, go to the full flat file.

Word Map on EC 4.1.1.33

Reaction

ATP
+
(R)-5-diphosphomevalonate
=
ADP
 +
phosphate
 +
isopentenyl diphosphate
 +
CO2

Synonyms

5-Pyrophosphomevalonate decarboxylase, Decarboxylase, pyrophosphomevalonate, diphosphomevalonate decarboxylase, diphosphomevalonte decarboxylase, DMD, DPM-DC, Fjoh_1389, MDD, MDP, Mevalonate (diphospho)decarboxylase, mevalonate 5'-diphosphate decarboxylase, Mevalonate 5-diphosphate decarboxylase, mevalonate diphosphate decarboxylase, mevalonate diphospho decarboxylase, Mevalonate pyrophosphate decarboxylase, mevalonate pyrophosphate decraboxylase, Mevalonate-5-pyrophosphate decarboxylase, More, MPD, MvaD, MVD, phosphomevalonate decarboxylase, PMD, Pyrophosphomevalonate decarboxylase, Pyrophosphomevalonic acid decarboxylase, ScMDD, ScMDD1, ScMDD2, scMVD, SSO2989

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.1 Carboxy-lyases
                4.1.1.33 diphosphomevalonate decarboxylase

Specific Activity

Specific Activity on EC 4.1.1.33 - diphosphomevalonate decarboxylase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.00000133
wild-type, 6xHis tagged, produced in Escherichia coli, 37°C, pH 7.4
0.00015
mutant S121A, pH 7.0, 30°C
0.2327
-
-
0.8
mutant S120A, pH 7.0, 30°C
0.85
mutant S155A, pH 7.0, 30°C
1.85
mutant W153F, pH 7.0, 30°C
14.4
mutant R193T, pH 7.0, 30°C
2.19
mutant S153A, pH 7.0, 30°C
3
mutant W19F, pH 7.0, 30°C
36.7
pH 8.0, temperature not specified in the publication
4.36
mutant S36A, pH 7.0, 30°C
6.26
-
-
8.6
wild-type, pH 7.0, 30°C
additional information