4.1.1.33: diphosphomevalonate decarboxylase

This is an abbreviated version!
For detailed information about diphosphomevalonate decarboxylase, go to the full flat file.

Word Map on EC 4.1.1.33

4.1.1.33

isoprenoids

mevalonate-5-phosphate

cholesterogenesis

6-fluoromevalonate

cholestyramine

polyisoprenoid

5-phosphomevalonate

synthesis

biofuel production

pharmacology

drug development

medicine

Reaction

Synonyms

5-Pyrophosphomevalonate decarboxylase, Decarboxylase, pyrophosphomevalonate, diphosphomevalonate decarboxylase, diphosphomevalonte decarboxylase, DMD, DPM-DC, Fjoh_1389, MDD, MDP, Mevalonate (diphospho)decarboxylase, mevalonate 5'-diphosphate decarboxylase, Mevalonate 5-diphosphate decarboxylase, mevalonate diphosphate decarboxylase, mevalonate diphospho decarboxylase, Mevalonate pyrophosphate decarboxylase, mevalonate pyrophosphate decraboxylase, Mevalonate-5-pyrophosphate decarboxylase, More, MPD, MvaD, MVD, phosphomevalonate decarboxylase, PMD, Pyrophosphomevalonate decarboxylase, Pyrophosphomevalonic acid decarboxylase, ScMDD, ScMDD1, ScMDD2, scMVD, SSO2989

ECTree

4 Lyases

4.1 Carbon-carbon lyases

4.1.1 Carboxy-lyases

4.1.1.33 diphosphomevalonate decarboxylase

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Results	in table
3	Activating Compound
6956	AA Sequence
5	Application
1	CAS Registry Number
18	Cloned(Commentary)
10	Cofactor
11	Crystallization (Commentary)
15	Disease/ Diagnostics
6	Expression
23	General Information
3	General Stability
13	IC50 Value
60	Inhibitors
13	kcat/KM [mM/s]
21	Ki Value [mM]
81	KM Value [mM]
12	Localization
29	Metals/Ions
36	Molecular Weight [Da]
27	Natural Substrates/ Products (Substrates)
89	Organism
7	Pathway
83	PDB ID
7	pH Optimum
3	pH Range
1	pH Stability
4	pI Value
3	Posttranslational Modification
52	Protein Variants
17	Purification (Commentary)
10	Reaction
1	Reaction Type
81	Reference
86	Source Tissue
19	Specific Activity [micromol/min/mg]
3	Storage Stability
109	Substrates and Products (Substrate)
32	Subunits
83	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
4	Temperature Stability [°C]
30	Turnover Number [1/s]

Purification

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Purification on EC 4.1.1.33 - diphosphomevalonate decarboxylase

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6 entries

2 enzyme forms: MW 37000 and MW 45000. The MW 37000 enzyme form is induced by the diet containing cholestyramine and pravastin

Rattus norvegicus

4383

both, the wild-type 6XHis tag ScMDD and the most active mutant R74H ScMDD2 purified by nickel affinity chromatography under anaerobic conditions, 90 to 95% homogenous

Saccharomyces cerevisiae

P32377

707234

Ni-Sepharose resin chromatography

Homo sapiens

P53602

690629

Ni2+ chelating column chromatography and HiTrapQ Sepharose column chromatography

2 entries

Ni2+-NTA-Sepharose column chromatography and Resource Q anion-exchange chromatography

Staphylococcus epidermidis

Q9FD73

715621

nickel affinity column chromatography and glutathione-Sepharose column chromatography

Streptococcus pneumoniae

714403

nickel metal affinity column chromatography

Rattus norvegicus

678692