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Literature summary for 4.1.1.33 extracted from

  • Chiew, Y.E.; O'Sullivan, W.J.; Lee, Ch.S.
    Studies on pig liver mevalonate-5-diphosphate decarboxylase (1987), Biochim. Biophys. Acta, 916, 271-278.
    View publication on PubMed
Search for more literature for 4.1.1.33

Inhibitors

Inhibitors Comment Organism Structure
MgADP-
-
 Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.45
-
 ATP 1 mM ATP4- above that complexed at the substrate. MgATP2- deceases the Km from 0.45 mM to 0.15 mM Sus scrofa
0.45
-
 ATP ATP in form of MgATP2- Sus scrofa
12.5
-
 5-diphosphomevalonate in presence of 4 mM MgCl2 and 3 mM ATP Sus scrofa

Metals/Ions

Metals/Ions Comment Organism Structure
Ba2+ 4 mM, activates at 17% of the activity of Mg2+ Sus scrofa
Ca2+ 4 mM, activates at 44% of the activity of Mg2+ Sus scrofa
Co2+ 4 mM, activates at 13% of the activity of Mg2+ Sus scrofa
Mg2+ 4 mM, activates Sus scrofa
Mn2+ 4 mM, activates at 37% of the activity of Mg2+ Sus scrofa
Ni2+ 4 mM, activates at 20% of the activity of Mg2+ Sus scrofa
Sr2+ 4 mM, activates at 22% of the activity of Mg2+ Sus scrofa

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
46000
-
 2 * 46000, SDS-PAGE Sus scrofa
88000
-
 gel filtration Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + (R)-5-diphosphomevalonate
-
 Sus scrofa ADP + phosphate + isopentenyl diphosphate + CO2
-
 ?
ATP + 5-diphosphomevalonate
-
 Sus scrofa ADP + phosphate + isopentenyl diphosphate + CO2
-
 ?
CTP + 5-diphosphomevalonate no activity Sus scrofa CDP + phosphate + isopentenyl diphosphate + CO2
-
 ?
dATP + 5-diphosphomevalonate about 59% of the activity with ATP Sus scrofa dADP + phosphate + isopentenyl diphosphate + CO2
-
 ?
GTP + 5-diphosphomevalonate about 10% of the activity with ATP Sus scrofa GDP + phosphate + isopentenyl diphosphate + CO2
-
 ?
ITP + 5-diphosphomevalonate about 6% of the activity with ATP Sus scrofa IDP + phosphate + isopentenyl diphosphate + CO2
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * 46000, SDS-PAGE Sus scrofa

Cofactor

Cofactor Comment Organism Structure
ATP 1 mM ATP4- above that complexed at the substrate. MgATP2- decreases the Km from 0.45 mM to 0.15 mM Sus scrofa