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Literature summary for 4.1.1.33 extracted from

  • Cardemil, E.; Jabalquinto, A.M.
    Mevalonate 5-pyrophosphate decarboxylase from chicken liver (1985), Methods Enzymol., 110, 86-92.
    View publication on PubMed
Search for more literature for 4.1.1.33

Inhibitors

Inhibitors Comment Organism Structure
adenosine 5'-O-(3-thiotriphosphate)
-
 Gallus gallus
citrate
-
 Gallus gallus
Phthalate
-
 Gallus gallus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0141
-
 5-diphosphomevalonate
-
 Gallus gallus
0.504
-
 ATP
-
 Gallus gallus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ divalent cation required, Mg2+ and Mn2+ being most effective Gallus gallus
Mn2+ divalent cation required, Mg2+ and Mn2+ being most effective Gallus gallus

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Gallus gallus

Reaction

Reaction Comment Organism Reaction ID
ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO2 sequential mechanism Gallus gallus
a

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Gallus gallus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Gallus gallus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 5-diphosphomevalonate high specificity for ATP Gallus gallus ADP + phosphate + isopentenyl diphosphate + CO2
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
4.5 7
-
 Gallus gallus