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4.1.1.33: diphosphomevalonate decarboxylase

This is an abbreviated version!
For detailed information about diphosphomevalonate decarboxylase, go to the full flat file.

Word Map on EC 4.1.1.33

Reaction

ATP
+
(R)-5-diphosphomevalonate
=
ADP
 +
phosphate
 +
isopentenyl diphosphate
 +
CO2

Synonyms

5-Pyrophosphomevalonate decarboxylase, Decarboxylase, pyrophosphomevalonate, diphosphomevalonate decarboxylase, diphosphomevalonte decarboxylase, DMD, DPM-DC, Fjoh_1389, MDD, MDP, Mevalonate (diphospho)decarboxylase, mevalonate 5'-diphosphate decarboxylase, Mevalonate 5-diphosphate decarboxylase, mevalonate diphosphate decarboxylase, mevalonate diphospho decarboxylase, Mevalonate pyrophosphate decarboxylase, mevalonate pyrophosphate decraboxylase, Mevalonate-5-pyrophosphate decarboxylase, More, MPD, MvaD, MVD, phosphomevalonate decarboxylase, PMD, Pyrophosphomevalonate decarboxylase, Pyrophosphomevalonic acid decarboxylase, ScMDD, ScMDD1, ScMDD2, scMVD, SSO2989

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.1 Carboxy-lyases
                4.1.1.33 diphosphomevalonate decarboxylase

Substrates Products

Substrates Products on EC 4.1.1.33 - diphosphomevalonate decarboxylase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(3R)-3-cyclopropyl-3-hydroxy-5-[[hydroxy(phosphonooxy)phosphoryl]oxy]pentanoic acid + ATP
?
show the reaction diagram
-
-
-
-
?
(3R)-3-ethyl-3-hydroxy-5-[[hydroxy(phosphonooxy)phosphoryl]oxy]pentanoic acid + ATP
?
show the reaction diagram
-
-
-
-
?
(3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)-4-methylpent-4-enoic acid + ATP
?
show the reaction diagram
-
-
-
-
?
(3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)-4-methylpentanoic acid + ATP
?
show the reaction diagram
-
-
-
-
?
(3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)-5-methylhexanoic acid + ATP
?
show the reaction diagram
-
-
-
-
?
(3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)heptanoic acid + ATP
?
show the reaction diagram
-
-
-
-
?
(3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)hex-4-ynoic acid + ATP
?
show the reaction diagram
-
-
-
-
?
(3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)hex-5-enoic acid + ATP
?
show the reaction diagram
-
-
-
-
?
(3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)pent-4-enoic acid + ATP
?
show the reaction diagram
-
-
-
-
?
(3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)pent-4-ynoic acid + ATP
?
show the reaction diagram
-
-
-
-
?
ATP + (R)-5-diphosphomevalonate
ADP + phosphate + isopentenyl diphosphate + CO2
show the reaction diagram
ATP + (R,S)-5-diphosphomevalonate
ADP + phosphate + isopentenyl diphosphate + CO2
show the reaction diagram
-
-
-
ir
ATP + 3-hydroxy-3-methylbutyrate
ADP + isobutene + CO2
show the reaction diagram
-
isobutene is identified by gas chromatography with flame ionization detection as well as by GC-mass spectrometry. Isobutene is an important commercial chemical used for the synthesis of butyl rubber, terephthalic acid, specialty chemicals, and a gasoline performance additive known as alkylate
-
?
ATP + 5-diphosphomevalonate
ADP + phosphate + isopentenyl diphosphate + CO2
show the reaction diagram
CTP + 5-diphosphomevalonate
CDP + phosphate + isopentenyl diphosphate + CO2
show the reaction diagram
dATP + 5-diphosphomevalonate
dADP + phosphate + isopentenyl diphosphate + CO2
show the reaction diagram
-
about 59% of the activity with ATP
-
-
?
diphosphomevalonate + ATP
isopentenyl diphosphate + ADP
show the reaction diagram
-
-
-
-
?
GTP + 5-diphosphomevalonate
GDP + phosphate + isopentenyl diphosphate + CO2
show the reaction diagram
ITP + 5-diphosphomevalonate
IDP + phosphate + isopentenyl diphosphate + CO2
show the reaction diagram
-
about 6% of the activity with ATP
-
-
?
UTP + 5-diphosphomevalonate
UDP + phosphate + isopentenyl diphosphate + CO2
show the reaction diagram
-
13% of the activity with ATP
-
?
additional information
?
-