4.1.1.33: diphosphomevalonate decarboxylase

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For detailed information about diphosphomevalonate decarboxylase, go to the full flat file.

Reaction

Synonyms

5-Pyrophosphomevalonate decarboxylase, Decarboxylase, pyrophosphomevalonate, diphosphomevalonate decarboxylase, diphosphomevalonte decarboxylase, DMD, DPM-DC, Fjoh_1389, MDD, MDP, Mevalonate (diphospho)decarboxylase, mevalonate 5'-diphosphate decarboxylase, Mevalonate 5-diphosphate decarboxylase, mevalonate diphosphate decarboxylase, mevalonate diphospho decarboxylase, Mevalonate pyrophosphate decarboxylase, mevalonate pyrophosphate decraboxylase, Mevalonate-5-pyrophosphate decarboxylase, More, MPD, MvaD, MVD, phosphomevalonate decarboxylase, PMD, Pyrophosphomevalonate decarboxylase, Pyrophosphomevalonic acid decarboxylase, ScMDD, ScMDD1, ScMDD2, scMVD, SSO2989

ECTree

     4 Lyases

         4.1 Carbon-carbon lyases

             4.1.1 Carboxy-lyases

                4.1.1.33 diphosphomevalonate decarboxylase

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Results	in table
3	Activating Compound
6956	AA Sequence
5	Application
1	CAS Registry Number
18	Cloned(Commentary)
10	Cofactor
11	Crystallization (Commentary)
15	Disease/ Diagnostics
6	Expression
23	General Information
3	General Stability
13	IC50 Value
60	Inhibitors
13	kcat/KM [mM/s]
21	Ki Value [mM]
81	KM Value [mM]
12	Localization
29	Metals/Ions
36	Molecular Weight [Da]
27	Natural Substrates/ Products (Substrates)
89	Organism
7	Pathway
83	PDB ID
7	pH Optimum
3	pH Range
1	pH Stability
4	pI Value
3	Posttranslational Modification
52	Protein Variants
17	Purification (Commentary)
10	Reaction
1	Reaction Type
81	Reference
86	Source Tissue
19	Specific Activity [micromol/min/mg]
3	Storage Stability
109	Substrates and Products (Substrate)
32	Subunits
83	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
4	Temperature Stability [°C]
30	Turnover Number [1/s]

pH Range

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pH Range on EC 4.1.1.33 - diphosphomevalonate decarboxylase

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pH RANGE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

4 - 10

Mus musculus

-

pH 3.0: about 5% of maximal activity, pH 4.0-7.0: maximal activity, pH 10.0: about 40% of maximal activity

650496

4 - 9

Rattus norvegicus

-

about 35% of maximal activity at pH 4 and at pH 9, 37000 MW enzyme form

4383

6 - 9

Rattus norvegicus

-

pH 6: about 35% of maximal activity, pH 9: about 30% of maximal activity, 45000 MW enzyme form

4383