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3.6.5.6: tubulin GTPase

This is an abbreviated version!
For detailed information about tubulin GTPase, go to the full flat file.

Word Map on EC 3.6.5.6

Reaction

GTP
+
H2O
=
GDP
 +
phosphate

Synonyms

atypical GTPase, BtubB, cell division protein, EC 3.6.1.51, eFtsZ, FtsZ, FtsZ tubulin-like protein, FtsZDr, gamma-tubulin, GTP phosphohydrolase, GTPase, guanine triphosphatase, guanosine 5'-triphosphatase, guanosine triphosphatase, mFtsZ, ORF156, ribosomal GTPase, TUBG1, tubulin, tubulin FtsZ, tubulin GTPase, tubulin homolog FtsZ, tubulin-colchicine GTPase

ECTree

     3 Hydrolases
         3.6 Acting on acid anhydrides
             3.6.5 Acting on GTP to facilitate cellular and subcellular movement
                3.6.5.6 tubulin GTPase

Activating Compound

Activating Compound on EC 3.6.5.6 - tubulin GTPase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2,3,4-trimethoxy-4'-(carbomethoxy)-1,1'-biphenyl
allocolchicine
-
-
ATP
ATP interacts with FtsZDr and stimulates its GTPase activity by about 2fold possibly by increasing both substrate affinity and rate of reaction
Colchicine
dimethyl sulfoxide
-
cosolvent stabilizes tubulin
glycerol
Gsalpha
-
Gsalpha facilitates GTP hydrolysis on tubulin, which leads to microtubule depolymerization by increased GTPase activation on tubulin
-
nocodazole
-
induced by this antimitotic drug, GTP hydrolysis rate stimulated four-to fivefold
quercetin
-
0.05 mM, stimulates GTPase activity about 8fold, but inhibits polymerization of microtubules and specifically inhibits colchicine binding to tubulin
sodium glutamate
-
cosolvent stabilizes tubulin
stathmin-like domains
-
-
-
sucrose
-
cosolvent stabilizes tubulin
tubulin folding cofactor
-
GTPase activating proteins A, B, C and D
-
additional information
-