3.6.5.6: tubulin GTPase

This is an abbreviated version!
For detailed information about tubulin GTPase, go to the full flat file.

Word Map on EC 3.6.5.6

3.6.5.6

polymerization

actin

cytoskeleton

mitotic

spindle

microtubule-associated

taxol

centrosome

paclitaxel

nucleation

tau

disassembly

antiproliferative

heterodimers

antimitotic

nerve

vinblastine

interphase

isotypes

nocodazole

microtubular

neurite

gtpases

pole

axonemal

vimentin

polymerized

neurofilament

kinesins

cortical

gdp

cytokine

cilia

myosin

dynein

lattice

metaphase

map2

microfilaments

taxanes

anaphase

urchin

multipolar

catastrophe

vincristine

kinetochore

microtubule-based

nestin

flagella

docetaxel

Reaction

Synonyms

atypical GTPase, BtubB, cell division protein, EC 3.6.1.51, eFtsZ, FtsZ, FtsZ tubulin-like protein, FtsZDr, gamma-tubulin, GTP phosphohydrolase, GTPase, guanine triphosphatase, guanosine 5'-triphosphatase, guanosine triphosphatase, mFtsZ, ORF156, ribosomal GTPase, TUBG1, tubulin, tubulin FtsZ, tubulin GTPase, tubulin homolog FtsZ, tubulin-colchicine GTPase

ECTree

3 Hydrolases

3.6 Acting on acid anhydrides

3.6.5 Acting on GTP to facilitate cellular and subcellular movement

3.6.5.6 tubulin GTPase

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Results	in table
25	Activating Compound
46	AA Sequence
1	CAS Registry Number
11	Cloned(Commentary)
6137	Disease/ Diagnostics
18	General Information
21	Inhibitors
11	KM Value [mM]
18	Localization
19	Metals/Ions
16	Molecular Weight [Da]
39	Natural Substrates/ Products (Substrates)
48	Organism
29	PDB ID
8	pH Optimum
2	pH Stability
1	pI Value
2	Posttranslational Modification
19	Protein Variants
24	Purification (Commentary)
2	Reaction
10	Reaction Type
48	Reference
41	Source Tissue
4	Specific Activity [micromol/min/mg]
3	Storage Stability
58	Substrates and Products (Substrate)
25	Subunits
43	Synonyms
1	Systematic Name
12	Temperature Optimum [°C]
1	Temperature Range [°C]
16	Turnover Number [1/s]

Inhibitors

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of the Enzyme Summary Page.

Inhibitors on EC 3.6.5.6 - tubulin GTPase

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Br-

Sus scrofa

733253

citral dimethyl acetal

Homo sapiens

P23258

CDA, impairs the GTPase activity of gamma-tubulin

756504

Cl-

Sus scrofa

enhancement of tubulin polymerization by Cl--induced blockade of intrinsic GTPase. GTPase activity of tubulin is lower (2/3-fold) in Cl--containing solutions than that in Cl--free solutions containing Br- or NO3-

733253

Colchicine

Homo sapiens

P23258

a small molecule inhibitor that binds to tubulin dimers rendering them unable to incorporate into filaments. It does not destabilize actively, but rather inhibit repolymerization after regular depolymerization

curcumin

diethyldicarbonate

inhibits GTP hydrolysis, but not the assembly reaction

644206

EDTA

Deinococcus radiodurans

Q9RWN5

strong inhibition at 2 mM

733983

GDP

2 entries

GTP

Bos taurus

inhibitory effect produced at concentrations above 3 mM, above 5 mM leads to depolymerization of microtubules

644199

guanosine 5'-(gamma-fluorotriphosphate)

Bos taurus

reversible competitive dead-end inhibitor

644199

guanosine 5'-(gamma-thiotriphosphate)

Bos taurus

inhibits both tubulin polymerization and GTP hydrolysis

644199

N-ethylmaleimide

Bos taurus

inhibits GTP hydrolysis, but not the assembly reaction

644206

N-terminal part of stathimin like-domains

NO3-

rotenone

rotenone inhibits both the assembly and the GTP hydrolysis rate of microtubules in vitro

686670

tubulin

Mus musculus

unassembled tubulin denatures relatively easily, and the denatured tubulin can inhibit the assembly itself

686631

vinblastine

2 entries

additional information

2 entries