3.6.5.6: tubulin GTPase
This is an abbreviated version!
For detailed information about tubulin GTPase, go to the full flat file.
Word Map on EC 3.6.5.6
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3.6.5.6
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polymerization
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actin
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cytoskeleton
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mitotic
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spindle
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microtubule-associated
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taxol
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centrosome
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paclitaxel
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nucleation
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tau
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disassembly
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antiproliferative
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heterodimers
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antimitotic
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nerve
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vinblastine
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interphase
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isotypes
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nocodazole
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microtubular
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neurite
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gtpases
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pole
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axonemal
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vimentin
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polymerized
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neurofilament
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kinesins
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cortical
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gdp
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cytokine
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cilia
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myosin
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dynein
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lattice
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metaphase
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map2
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microfilaments
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taxanes
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anaphase
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urchin
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multipolar
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catastrophe
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vincristine
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kinetochore
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microtubule-based
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nestin
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flagella
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docetaxel
- 3.6.5.6
- polymerization
- actin
- cytoskeleton
-
mitotic
- spindle
-
microtubule-associated
- taxol
- centrosome
- paclitaxel
-
nucleation
- tau
-
disassembly
-
antiproliferative
- heterodimers
-
antimitotic
- nerve
- vinblastine
-
interphase
-
isotypes
- nocodazole
- microtubular
-
neurite
- gtpases
- pole
-
axonemal
- vimentin
-
polymerized
- neurofilament
- kinesins
- cortical
- gdp
- cytokine
- cilia
- myosin
- dynein
-
lattice
-
metaphase
- map2
-
microfilaments
-
taxanes
-
anaphase
- urchin
-
multipolar
-
catastrophe
- vincristine
- kinetochore
-
microtubule-based
- nestin
- flagella
- docetaxel
Reaction
Synonyms
atypical GTPase, BtubB, cell division protein, EC 3.6.1.51, eFtsZ, FtsZ, FtsZ tubulin-like protein, FtsZDr, gamma-tubulin, GTP phosphohydrolase, GTPase, guanine triphosphatase, guanosine 5'-triphosphatase, guanosine triphosphatase, mFtsZ, ORF156, ribosomal GTPase, TUBG1, tubulin, tubulin FtsZ, tubulin GTPase, tubulin homolog FtsZ, tubulin-colchicine GTPase
ECTree
3.6.5.6 tubulin GTPaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 3.6.5.6 - tubulin GTPase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
GTP + H2O
GDP + phosphate
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?
GTP + H2O
GDP + phosphate
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GTP-binding proteins from the tubulin family, including alpha,beta-tubulin are key components of the cytoskeleton and play central roles in chromosome segregation and cell division. The nucleotide switch of alpha,beta-tubulin is triggered by GTP hydrolysis and regulates microtubule assembly dynamics. Unassembled tubulin-GTP is in the inactive, curved conformation as in tubulin-GDP rings, and is driven into the straight microtubule conformation by the assembly contacts. Binding of the GTP gamma-phosphate only lowers the free energy difference between the curved and straight forms
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-
?
GTP + H2O
GDP + phosphate
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GTP-binding proteins from the tubulin family, including alpha,beta-tubulin are key components of the cytoskeleton and play central roles in chromosome segregation and cell division. The nucleotide switch of alpha,beta-tubulin is triggered by GTP hydrolysis and regulates microtubule assembly dynamics. Unassembled tubulin-GTP is in the inactive, curved conformation as in tubulin-GDP rings, and is driven into the straight microtubule conformation by the assembly contacts. Binding of the GTP gamma-phosphate only lowers the free energy difference between the curved and straight forms
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?
additional information
?
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enzyme FtsZDr acts as a GTPase exhibiting polymerization/depolymerization dynamics in vitro and FtsZ ring formation in vivo
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?
additional information
?
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enzyme FtsZDr acts as a GTPase exhibiting polymerization/depolymerization dynamics in vitro and FtsZ ring formation in vivo
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?
