3.6.1.62: 5'-(N7-methylguanosine 5'-triphospho)-[mRNA] hydrolase
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For detailed information about 5'-(N7-methylguanosine 5'-triphospho)-[mRNA] hydrolase, go to the full flat file.
Reaction
Synonyms
D10 decapping enzyme, D10 protein, D9 protein, Dcp1p, Dcp2, Dcp2p, decapping nudix hydrolase, EC 3.6.1.30, H29K, hDcp2, hNUDT16, mRNA decapping enzyme, mRNA decapping enzyme D10, mRNA decapping enzyme D9, Nudt16, Nudt17, Nudt19, Nudt20, NUDT3, U8 snoRNA binding protein, X29, X29 protein
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General Information
General Information on EC 3.6.1.62 - 5'-(N7-methylguanosine 5'-triphospho)-[mRNA] hydrolase
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malfunction
physiological function
no obvious phenotypic difference or differences in fertility, life span, or litter size are detected between the wild type animals and Dcp2b/b mice (mice containing a homozygous insertion of the beta-geo gene as Dcp2beta/beta)
malfunction
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null mutants of DCP1 accumulate capped mRNAs with a reduced degradation rate. Lethal phenotype at the seedling cotyledon stage, with disorganized veins, swollen root hairs, and altered epidermal cell morphology
malfunction
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enzyme-deficient viruses are attenuated in mice. Decapping-deficient vaccinia virus also potently reduces tumor growth in a human hepatocellular carcinoma xenograft model
malfunction
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reduction of enzyme protein levels in MCF-7 cells promotes increased cell migration and corresponding enhanced filopodia extensions. Enzyme depletion elevates RNA and protein expression of integrin beta6 and fibronectin, which in turn increases MCF-7 cell motility
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D9 is expressed early in infection and D10 late. It is suggested that the two proteins enhance mRNA turnover and manipulate gene expression in a complementary and overlapping manner
physiological function
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mRNA decapping is a critical step in the control of mRNA stability and gene expression
physiological function
Nudt16, like Dcp2, is involved in mRNA stability. Each decapping enzyme can selectively affect the stability of at least a subset of mRNAs
physiological function
Nudt16, like Dcp2, is involved in mRNA stability. Each decapping enzyme can selectively affect the stability of at least a subset of mRNAs
physiological function
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the mRNA decapping activity of D10 allows Vaccinia virus to accelerate degradation of viral and host messages. By degrading host mRNAs, VACV D10 may have an immunomodulatory role. Although it may seem self-destructive for a virus to encode a decapping and a capping enzyme, accelerated mRNA turnover helps eliminate competing host mRNAs and allows stagespecific synthesis of viral proteins
physiological function
the presence or absence of detectable Dcp2 does not appreciably alter stability of the transfected RNA and suggests Dcp2 may not be involved in bulk mRNA decapping in cells. Dcp2 appears to be a minor contributor to mRNA stability and raises the intriguing possibility for the presence of a Dcp2-independent decapping activity in mammalian cells
physiological function
embryonic fibroblast cells with reduced Dcp2 levels contain significantly elevated levels of mRNAs encoding proteins involved in the type I IFN response. Both IRF-7 mRNA and protein are increased in cells with reduced Dcp2 levels. The increase in IRF-7 mRNA within the background of reduced Dcp2 levels is attributed to a stabilization of the IRF-7 mRNA, suggesting that Dcp2 normally modulates IRF-7 mRNA stability
physiological function
many long noncoding RNAs degraded by DCP2 are expressed proximal to inducible genes. Of these, several genes required for galactose utilization are associated with long noncoding RNAs that have expression patterns inversely correlated with their mRNA counterpart. Decapping of these lncRNAs is critical for rapid and robust induction of GAL gene expression
physiological function
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the enzyme is a modulator of MCF-7 breast cancer cell migration
physiological function
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the enzyme regulates mRNA stability in cells